Class 3 Hydrolases pp 332-336 | Cite as
Anthrax lethal factor endopeptidase
Chapter
Keywords
Protective Antigen Bacillus Anthracis Lethal Factor Lethal Toxin Anthrax Toxin
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References
- [1]Vitale, G; Bernardi, L; Napolitani, G; Mock, M; Montecucco, C.: Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem. J., 352, 739–745 (2000)PubMedCrossRefGoogle Scholar
- [2]Duesbery, N.S., Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science, 280, 734–737 (1998)PubMedCrossRefGoogle Scholar
- [3]Pannifer, A.D.; Wong, T.Y.; Schwarzenbacher, R.; Renatus, M.; Petosa, C.; Bienkowska, J.; Lacy, D.B.; Collier, R.J.; Park, S.; Leppla, S.H.; Hanna, P.; Liddington, R.C.: Crystal structure of the anthrax lethal factor. Nature, 414, 229–233 (2001)PubMedCrossRefGoogle Scholar
- [4]Tonello, F.; Ascenzi, P.; Montecucco, C.: The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited. J. Biol. Chem., 278, 40075–40078 (2003)PubMedCrossRefGoogle Scholar
- [5]Pellizzari, R.; Guidi-Rontani, C.; Vitale, G.; Mock, M.; Montecucco, C.: Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ-induced release of NO and TNFα. FEBS Lett., 462, 199–204 (1999)PubMedCrossRefGoogle Scholar
- [6]Rossetto, O.; de Bernard, M.; Pellizzari, R.; Vitale, G.; Caccin, P.; Schiavo, G.; Montecucco, C.: Bacterial toxins with intracellular protease activity. Clin. Chim. Acta, 291, 189–199 (2000)PubMedCrossRefGoogle Scholar
- [7]Glomski, I.J.; Fritz, J.H.; Keppler, S.J.; Balloy, V.; Chignard, M.; Mock, M.; Goossens, P.L.: Murine splenocytes produce inflammatory cytokines in MyD88-dependent response to Bacillus anthracis spores. cell. Microbiol., 9, 502–513 (2007)PubMedCrossRefGoogle Scholar
- [8]Gubbins, M.J.; Berry, J.D.; Corbett, C.R.; Mogridge, J.; Yuan, X.Y.; Schmidt, L.; Nicolas, B.; Kabani, A.; Tsang, R.S.: Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen. FEMS Immunol. Med. Microbiol., 47, 436–443 (2006)PubMedCrossRefGoogle Scholar
- [9]Bergman, N.H.; Passalacqua, K.D.; Gaspard, R.; Shetron-Rama, L.M.; Quackenbush, J.; Hanna, P.C.: Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication. Infect. Immun., 73, 1069–1080 (2005)PubMedCrossRefGoogle Scholar
- [10]Comer, J.E.; Galindo, C.L.; Chopra, A.K.; Peterson, J.W.: GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis. Infect. Immun., 73, 1879–1885 (2005)PubMedCrossRefGoogle Scholar
- [11]Koya, V.; Moayeri, M.; Leppla, S.H.; Daniell, H.: Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun., 73, 8266–8274 (2005)PubMedCrossRefGoogle Scholar
- [12]Xu, L.; Frucht, D.M.: Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses. Int. J. Biochem. Cell Biol., 39, 20–24 (2007)PubMedCrossRefGoogle Scholar
- [13]Baillie, L.W.J.: Past, imminent and future human medical countermeasures for anthrax. J. Appl. Microbiol., 101, 594–606 (2006)PubMedCrossRefGoogle Scholar
- [14]Cui, X.; Li, Y.; Li, X.; Haley, M.; Moayeri, M.; Fitz, Y.; Leppla, S.H.; Eichacker, P.Q.: Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival. J. Infect. Dis., 193, 829–840 (2006)PubMedCrossRefGoogle Scholar
- [15]Gujraty, K.; Sadacharan, S.; Frost, M.; Poon, V.; Kane, R.S.; Mogridge, J.: Functional characterization of peptide-based anthrax toxin inhibitors. Mol. Pharmacol., 2, 367–372 (2005)CrossRefGoogle Scholar
- [16]Boyden, E.D.; Dietrich, W.F.: Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet., 38, 240–244 (2006)PubMedCrossRefGoogle Scholar
- [17]Mendelson, I.; Gat, O.; Aloni-Grinstein, R.; Altboum, Z.; Inbar, I.; Kronman, C.; Bar-Haim, E.; Cohen, S.; Velan, B.; Shafferman, A.: Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components. Vaccine, 23, 5688–5697 (2005)PubMedCrossRefGoogle Scholar
- [18]Sloat, B.R.; Cui, Z.: Nasal immunozation with a dual antigen anthrax vacine induced strong mucosal and systemic immune responses against toxins and bacilli. Vaccine, 24, 6405–6413 (2006)PubMedCrossRefGoogle Scholar
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