AGN Simulation and Validation Model

  • Fabrício M. Lopes
  • Roberto M. CesarJr
  • Luciano da F. Costa
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5167)


An important question in computational biology is how genes are regulated and interact through gene networks. Some methods for the identification of gene networks from temporal data were proposed. An important open problem regards how to validate such resulting networks. This work presents an approach to validate such algorithms, considering three main aspects: (1) AGN model generation and simulation; (2) gene network identification; (3) validation of identified network.


Gene Network Probabilistic Boolean Network Rule Table Sequential Forward Float Selection Intraerythrocytic Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Fabrício M. Lopes
    • 1
    • 3
  • Roberto M. CesarJr
    • 1
  • Luciano da F. Costa
    • 2
  1. 1.Instituto de Matemática e EstatísticaUniversidade de São PauloBrazil
  2. 2.Instituto de Física de São CarlosUniversidade de São PauloBrazil
  3. 3.Universidade Tecnológica Federal do ParanáBrazil

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