Biological Activities of Kinetin

  • Kalina Duszka
  • Brian F.C. Clark
  • Frank Massino
  • Jan Barciszewski
Chapter

Abstract

Kinetin (N6-furfuryladenine) is a cytokinin growth factor with several biological effects observed for human cells and fruit flies. It was given the name kinetin because of its ability to induce cell division. Kinetin is often used in plant cell and tissue culture for induction of callus formation (in conjunction with auxin) and to regenerate shoots from callus (with lower auxin concentration). Kinetin exists naturally in the DNA of almost all organisms tested so far, including human cells, and various plants. The mechanism of kinetin synthesis in DNA is thought to be via the production of furfural, an oxidative damage product of DNA deoxyribose, and it is quenched by the adenine base converting it into N6-furfuryladenine. Since 1994 kinetin has been thoroughly tested for its powerful antiaging effects in human skin cells and other systems. At present, kinetin is one of the most widely used components in numerous skin care cosmetics and cosmeceuticals. There are some reports published on other biological effects of kinetin in human beings, as an antiplatelet aggregation factor reducing thrombus formation, and its ability to correct genetic diseases of RNA missplicing. Kinetin was shown to be more effective in the improvement of skin texture, making it smoother and with a significant reduction in fine lines and wrinkles. It is a stable antioxidant that slows down the aging process.

Keywords

cytokinins kinetin DNA damage biological activity antiaging 
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References

  1. 1.
    Miller CO, Skoog F, Okumura FS, Von Saltza MH, Strong FM (1955) J Am Chem Soc 78:1375CrossRefGoogle Scholar
  2. 2.
    Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1996) FEBS Lett 393:197CrossRefGoogle Scholar
  3. 3.
    Barciszewski J, Mielcarek M, Stobiecki M, Siborska G, Clark BFC (2000) Biochem Biophys Res Commun 179:69CrossRefGoogle Scholar
  4. 4.
    Ge L, Yong JW, Goh NK, Chia LS, Tan SN, Ong ES (2005) J Chromatogr B Analyt Technol Biomed Life Sci 829:26CrossRefGoogle Scholar
  5. 5.
    Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1997a) Biochem Biophys Res Commun 238:317Google Scholar
  6. 6.
    Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SI (1997b) FEBS Lett 414:457Google Scholar
  7. 7.
    Wyszko E, Barciszewska MZ, Markiewicz M, Szymanski M, Markiewicz WT, Clark BFC, Barciszewski J (2003) Biochim Biophys Acta 1625:239Google Scholar
  8. 8.
    Mok DWS, Mok MC (2001) Annu Rev Plant Physiol Plant Mol Biol 52:89CrossRefGoogle Scholar
  9. 9.
    Hou B, Lim EK, Higgins GS, Bowles DJ (2004) J Biol Chem 279:47822CrossRefGoogle Scholar
  10. 10.
    Brzobohatý B, Moore I, Kristoffersen P, Bako L, Campos N, Schell J, Palme K. (1993) Science 262:1051CrossRefGoogle Scholar
  11. 11.
    Letham DS, Palni LMS (1983) Annu Rev Plant Physiol 34:163CrossRefGoogle Scholar
  12. 12.
    Armstrong DJ (1994) In: Mok DWS, Mok MC (eds) Cytokinins, Chemistry, Activity and Function. CRC Press, Boca Raton, FL, p 139Google Scholar
  13. 13.
    Molina1 RV, Castelló S, García-Luis A, Guardiola JL (2007) Plant Cell Tissue Organ Cult 89:131CrossRefGoogle Scholar
  14. 14.
    Papon N, Bremer J, Vansiri A, Andreu F, Rideau M, Creche J (2005) Planta Med 71:572CrossRefGoogle Scholar
  15. 15.
    Pasqua G, Monacelli B, Mulinacci N, Rinaldi S, Giaccherini C, Innocenti M, Vinceri FF (2005) Plant Physiol Biochem 43:293CrossRefGoogle Scholar
  16. 16.
    Yaronskaya EB, Gritskevitch ER, Trukhanovets NL, Averina NG (2007) Russian J Plant Physiol 54:388CrossRefGoogle Scholar
  17. 17.
    Shibaoka H. Thimann KV (1970) Plant Physiol 46:212Google Scholar
  18. 18.
    Debi RB, Taketa S, Ichii M (2005) J Plant Physiol 162:507CrossRefGoogle Scholar
  19. 19.
    Li X, Mo X, Shou H, Wu P (2006) Plant Cell Physiol 47:1112CrossRefGoogle Scholar
  20. 20.
    Filek M, Zȩ bala M, Szechyńska-Hebda M (2002) Z Naturforsch 57:696Google Scholar
  21. 21.
    Venis MA, Thomas EW, Barbier-Brygoo H, Ephritikhine G, Guen J (1990) Planta 182:232CrossRefGoogle Scholar
  22. 22.
    Gzyl-Malchera B, Filek M, Brezesinski G, Fischer A (2007) Z Naturforsch 62:55Google Scholar
  23. 23.
    Gaudino RJ, Pikaard CS (1997) J Biol Chem 272:6799CrossRefGoogle Scholar
  24. 24.
    Zhang K, Letham DS, John PC (1996) Planta 200:2CrossRefGoogle Scholar
  25. 25.
    Turck F, Zilbermann F, Kozma SC, Thomas G, Nagy F (2004) Plant Physiol 134:1527CrossRefGoogle Scholar
  26. 26.
    Balibrea LME, Garcia GMC, Fatima T, Ehness R, Lee TK, Proels R, Tanner W, Roitsch T (2004) Plant Cell 16:1276CrossRefGoogle Scholar
  27. 27.
    Koistinen KM, Soininen P, Venäläinen TA, Häyrinen J, Laatikainen R, Peräkylä M, Tervahauta AI, Kärenlampi SO (2005) Phytochemistry 66:2524CrossRefGoogle Scholar
  28. 28.
    Hurtado-Guerrero R, van Aalten DMF (2007) Chem Biol 14:589CrossRefGoogle Scholar
  29. 29.
    Barna B, Fodor J, Pogány M, Király Z (2003) Pest Manag Sci 59:549CrossRefGoogle Scholar
  30. 30.
    Balázs E, Barna B, Király Z (1976) Acta Phytopath Acad Sci Hung 11:1Google Scholar
  31. 31.
    Yang F, Simpson RB (1981) Proc Natl Acad Sci USA 78:4151CrossRefGoogle Scholar
  32. 32.
    Schumaker KS, Gizinski MJ (1995) J Biol Chem 270:23461CrossRefGoogle Scholar
  33. 33.
    Connett RJA, Hanke DE (1987) Planta 170:161CrossRefGoogle Scholar
  34. 34.
    Pharmawati M, Billington T, Gehring CA (1998) Cell Mol Life Sci 54:272CrossRefGoogle Scholar
  35. 35.
    Raman N, Elumalai S (1996) Ind J Exp Biol 34:577Google Scholar
  36. 36.
    Santos R, Hèrouart D, Sigaud S, Touati D, Puppo A (2001) Mol Plant Microbe Interact 14:86CrossRefGoogle Scholar
  37. 37.
    Rattan SI (2002) J Anti-aging Med 5:113CrossRefGoogle Scholar
  38. 38.
    Inoue H, Hirobe M (1986) Biochem Biophys Res Commun 137:372CrossRefGoogle Scholar
  39. 39.
    Sharma SP, Kaur P, Rattan SI (1995) Biochem Biophys Res Commun 216:1067CrossRefGoogle Scholar
  40. 40.
    Sharma SP, Kaur J, Rattan SI (1997) Biochem Mol Biol Int 41:869Google Scholar
  41. 41.
    Olsen A, Siboska GE, Clark BFC, Rattan SI (1999) Biochem Biophys Res Commun 265:499CrossRefGoogle Scholar
  42. 42.
    Pischetsrieder M, Seidel W, Munch G, Schinzel R (1999) Biochem Biophys Res Commun 264:544CrossRefGoogle Scholar
  43. 43.
    Yokosuka K, Park JS, Jimbo K, Yamada K, Sato K, Tsuru M, Takeuchi M, Yamagishi S, Nagata K (2006) J Neurosurg Spine 5:324CrossRefGoogle Scholar
  44. 44.
    Hamada Y, Araki N, Koh N, Nakamura J, Horiuchi S, Hotta N (1996) Biochem Biophys Res Commun 228:539CrossRefGoogle Scholar
  45. 45.
    Cervantes-Laurean D, Jacobson EL, Jacobson MK (1996) J Biol Chem 271:10461CrossRefGoogle Scholar
  46. 46.
    Verbeke P, Siboska GE, Clark BFC, Rattan SI (200) Biochem Biophys Res Commun 276:1265CrossRefGoogle Scholar
  47. 47.
    Rup PJ, Sohal SK, Kaur H (2006) J Environ Biol 27:579Google Scholar
  48. 48.
    Orr MF, McSwain B (1960) Cancer Res 20:1362Google Scholar
  49. 49.
    Kimura T, Doi K (2004) Rejuvenat Res 7:32CrossRefGoogle Scholar
  50. 50.
    Vicanova J, Bouez C, Lacroix S, Lindmark L, Damour O (2006) Ann NY Acad Sci 1067:337CrossRefGoogle Scholar
  51. 51.
    Berge U, Kristensen P, Rattan SI (2006) Ann NY Acad Sci 1067:332CrossRefGoogle Scholar
  52. 52.
    Orr MF, McSwain B (1957) Cancer 10:617CrossRefGoogle Scholar
  53. 53.
    Kowalska E (1992) Folia Morphol 51:109Google Scholar
  54. 54.
    Honma Y, Ishii Y (2002) Leuk Lymphoma 43:1729CrossRefGoogle Scholar
  55. 55.
    Honma Y (2003) Drug Dev Res 59:14CrossRefGoogle Scholar
  56. 56.
    Ishii Y, Hori Y, Sakai S, Honma Y (2002) Cell Growth Differ 13:19Google Scholar
  57. 57.
    Griffaut B, Bos R, Maurizis JC, Madelmont JC, Ledoigt G (2004) Int J Biol Macromol 34:271CrossRefGoogle Scholar
  58. 58.
    Ishii Y, Sakai S, Honma Y (2003) Biochim Biophys Acta 1643:11CrossRefGoogle Scholar
  59. 59.
    Becker T, Gerke V, Kube E, Weber K (1992) Eur J Biochem 207:541CrossRefGoogle Scholar
  60. 60.
    Sato N, Hitomi J (2002) Anat Rec 276:60CrossRefGoogle Scholar
  61. 61.
    Bullinger L, Dohner K, Bair E, Frohling S, Schlenk RF, Tibshirani R, Dohner H, Pollack JR (2004) N Engl J Med 350:1605CrossRefGoogle Scholar
  62. 62.
    Slaugenhaupt SA, Blumenfeld A, Gill SP, Leyne M, Mull J, Cuajungco MP, Liebert CB, Chadwick B, Idelson M, Reznik L, Robbins C, Makalowska I, Brownstein M, Krappmann D, Scheidereit C, Maayan C, Axelrod FB, Gusella JF (2001) Am J Hum Genet 68:598CrossRefGoogle Scholar
  63. 63.
    Hims MM, Ibrahim el C, Leyne M, Mull J, Liu L, Lazaro C, Shetty RS, Gill S, Gusella JF, Reed R, Slaugenhaupt SA (2007) J Mol Med 85:149CrossRefGoogle Scholar
  64. 64.
    Adunka O, Moustaklis E, Weber A, May A, von Ilberg C, Gstoettner W, Kierner AC (2003) ORL J Otorhinolaryngol Relat Spec 65:84Google Scholar
  65. 65.
    Chimini G, Chavrier P (2000) Nat Cell Biol 2:191CrossRefGoogle Scholar
  66. 66.
    Ivetic A, Ridley AJ (2004) Immunology 112:165CrossRefGoogle Scholar
  67. 67.
    Kamino H, Hiratsuka M, Toda T, Nishigaki R, Osaki M, Ito H, Inoue T, Oshimura M (2003) Cell Struct Funct 28:495CrossRefGoogle Scholar
  68. 68.
    Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y (1997) J Biol Chem 272:23371CrossRefGoogle Scholar
  69. 69.
    Lee JH, Chung KY, Bang D, Lee KH (2006) Proteomics 6:1351CrossRefGoogle Scholar
  70. 70.
    Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P (2001) Exp Gerontol 36:1327CrossRefGoogle Scholar
  71. 71.
    Sheu JR, Hsiao G, Shen MY, Chou CY, Lin CH, Chen TF, Chou DS (2003) Platelets ,v>14:189Google Scholar
  72. 72.
    Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR (2003) Eur J Pharmacol 465:281CrossRefGoogle Scholar
  73. 73.
    Froldi G, Gallo U, Ragazzi E, Caparrotta L (1999) Planta Med 65:245CrossRefGoogle Scholar
  74. 74.
    Vesely DL, Hudson JL, Pipkin JL Jr, Pack LD, Meiners SE (1985) Endocrinology 116:1887CrossRefGoogle Scholar
  75. 75.
    Çelik I, Özbek H, Tülüce Y (2002) J Biol 26:193Google Scholar
  76. 76.
    Ciftci M, Demir Y, Ozmen I, Atici O (2003) J Enzyme Inhib Med Chem 18:71CrossRefGoogle Scholar
  77. 77.
    Barciszewski J, Otzen D, Rattan SI, Clark BFC (1994) Biochem Int 28:805Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Kalina Duszka
  • Brian F.C. Clark
    • 1
  • Frank Massino
    • 1
  • Jan Barciszewski
    • 1
  1. 1.Institute for Bioorganic ChemistryPolish Academy of SciencesPoland

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