Sensory Nerves pp 261-281 | Cite as

Transient Receptor Potential Channels on Sensory Nerves

Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 194)

Abstract

The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of “thermoTRPs” TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 in nociception. In concert, through the efforts of many industrial and academic teams, a number of agonists and antagonists of these channels have been discovered, paving the way for a better understanding of sensory biology and, potentially, for novel treatments for diseases.

Keywords

TRPV1 TRPV2 TRPV3 TRPV4 TRPA1 TRPM8 Pain Nociceptors Sensory system Channels Agonists Antagonists 

Abbreviations

2-APB

2-Aminoethoxydiphenyl borate

CFA

Complete Freund's adjuvant

DRG

Dorsal root ganglion

PIP2

Phosphatidylinositol 4,5-bisphosphate

RTX

Resiniferatoxin

TRP

Transient receptor potential

TRPA1

Transient receptor potential ankyrin subfamily, member 1

TRPM8

Transient receptor potential melastatin subfamily, member 8

TRPV1

Transient receptor potential vanilloid subfamily, member 1

TRPV2

Transient receptor potential vanilloid subfamily, member 2

TRPV3

Transient receptor potential vanilloid subfamily, member 3

TRPV4

Transient receptor potential vanilloid subfamily, member 4

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Pain Research, Neuroscience Drug DiscoveryMerck Research LaboratoriesWest PointUSA
  2. 2.Department of Biochemistry and Molecular BiologyNeurogen CorporationBranfordUSA

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