Sensory Nerves pp 139-183 | Cite as

Sensory Nerves and Airway Irritability

Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 194)

Abstract

The lung, like many other organs, is innervated by a variety of sensory nerves and by nerves of the parasympathetic and sympathetic nervous systems that regulate the function of cells within the respiratory tract. Activation of sensory nerves by both mechanical and chemical stimuli elicits a number of defensive reflexes, including cough, altered breathing pattern, and altered autonomic drive, which are important for normal lung homeostasis. However, diseases that afflict the lung are associated with altered reflexes, resulting in a variety of symptoms, including increased cough, dyspnea, airways obstruction, and bronchial hyperresponsiveness. This review summarizes the current knowledge concerning the physiological role of different sensory nerve subtypes that innervate the lung, the factors which lead to their activation, and pharmacological approaches that have been used to interrogate the function of these nerves. This information may potentially facilitate the identification of novel drug targets for the treatment of respiratory disorders such as cough, asthma, and chronic obstructive pulmonary disease.

Keywords

Rapidly adapting receptors C-fibers Cough receptor Cough Parasympathetic nervous system Sympathetic nervous system Cough Bronchoconstriction Mucus secretion Bronchial hyperresponsiveness 

References

  1. Adcock JJ, Douglas GJ, Garabette M, Gascoigne M, Beatch G, Walker M, Page CP (2003) RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol 138:407–416PubMedGoogle Scholar
  2. Advenier C, Emonds-Alt X (1996) Tachykinin receptor antagonists and cough. Pulm Pharmacol 9:329–333PubMedGoogle Scholar
  3. Ahlstedt S, Alving K, Hesselmar B, Olaisson E (1986) Enhancement of the bronchial reactivity in immunized rats by neonatal treatment with capsaicin. Int Arch Allergy Appl Immunol 80:262–266PubMedGoogle Scholar
  4. Aikawa T, Sekizawa K, Itabashi S, Sasaki H, Takishima T (1990) Inhibitory actions of prostaglandin E1 on non-adrenergic non-cholinergic contraction in guinea-pig bronchi. Br J Pharmacol 101(1):13–14PubMedGoogle Scholar
  5. Aizawa H, Matsuzaki Y, Ishibashi M, Domae M, Hirose T, Shigematsu N, Tanaka K (1982) A possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity. Respir Physiol 50:187–196PubMedGoogle Scholar
  6. Aizawa H, Tanaka H, Sakai J, Takata S, Hara N, Ito Y (1997) L-NAME-sensitive and -insensitive nonadrenergic noncholinergic relaxation of cat airway in vivo and in vitro. Eur Respir J 10:314–321PubMedGoogle Scholar
  7. Aizawa H, Takata S, Inoue H, Matsumoto K, Koto H, Hara N (1999) Role of nitric oxide released from iNANC neurons in airway responsiveness in cats. Eur Respir J 13(4):775–780PubMedGoogle Scholar
  8. An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L (2007) Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 29:834–860PubMedGoogle Scholar
  9. Andresen JH, Saugstad OD (2008) Effects of nicotine infusion on striatal glutamate and cortical non-protein-bound iron in hypoxic newborn piglets. Neonatology 94:284–292Google Scholar
  10. Armstrong DJ, Luck JC (1974) A comparative study of irritant and type J receptors in the cat. Respir Physiol 21:47–60PubMedGoogle Scholar
  11. Avital A, Springer C, Bar-Yishay E, Godfrey S (1995) Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease. Thorax 50:511–516PubMedGoogle Scholar
  12. Aylwin ML, Horowitz JM, Bonham AC (1997) NMDA receptors contribute to primary visceral afferent transmission in the nucleus of the solitary tract. J Neurophysiol 77:2539–2548PubMedGoogle Scholar
  13. Bachoo M, Polosa C (1987) Properties of the inspiration-related activity of sympathetic preganglionic neurones of the cervical trunk in the cat. J Physiol 385:545–564PubMedGoogle Scholar
  14. Bai TR, Macklem PT, Martin JG (1986) The effects of parasympathectomy on serotonin-induced bronchoconstriction in the cat. Am Rev Respir Dis 133:110–115PubMedGoogle Scholar
  15. Baluk P, Nadel JA, McDonald DM (1992) Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J Comp Neurol 319:586–598PubMedGoogle Scholar
  16. Barman SM, Gebber GL (1976) Basis for synchronization of sympathetic and phrenic nerve discharges. Am J Physiol 231:1601–1607PubMedGoogle Scholar
  17. Barnes PJ (1986) Asthma as an axon reflex. Lancet 1(8475):242–245PubMedGoogle Scholar
  18. Barnes PJ (2001) Neurogenic inflammation in the airways. Respir Physiol 125:145–154PubMedGoogle Scholar
  19. Barnes PJ, Adcock IM (1997) NF-kappa B: a pivotal role in asthma and a new target for therapy. Trends Pharmacol Sci 18:46–50PubMedGoogle Scholar
  20. Beier KC, Kallinich T, Hamelmann E (2007) T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease. Eur Respir J 30:383–390PubMedGoogle Scholar
  21. Belvisi MG, Chung KF, Jackson DM, Barnes PJ (1988) Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo. Br J Pharmacol 95:413–418PubMedGoogle Scholar
  22. Belvisi MG, Ichinose M, Barnes PJ (1989) Modulation of non-adrenergic, non-cholinergic neural bronchoconstriction in guinea-pig airways via GABAB-receptors. Br J Pharmacol 97: 1225–1231PubMedGoogle Scholar
  23. Bergren DR (1997) Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs. Respir Physiol 108:195–204PubMedGoogle Scholar
  24. Bergren DR (2006) Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs. J Appl Physiol 100(6):1918–1927PubMedGoogle Scholar
  25. Berman AR, Togias AG, Skloot G, Proud D (1995) Allergen-induced hyperresponsiveness to bradykinin is more pronounced than that to methacholine. J Appl Physiol 78:1844–1852PubMedGoogle Scholar
  26. Bhatia M, Zhi L, Zhang H, Ng SW, Moore PK (2006) Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. Am J Physiol Lung Cell Mol Physiol 291:L896–L904PubMedGoogle Scholar
  27. Binshtok AM, Bean BP, Woolf CJ (2007) Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449:607–610PubMedGoogle Scholar
  28. Birrell MA, Crispino N, Hele DJ, Patel HJ, Yacoub MH, Barnes PJ, Belvisi MG (2002) Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD. Br J Pharmacol 136:620–628PubMedGoogle Scholar
  29. Bolser DC, Aziz SM, Chapman RW (1991) Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs. Neurosci Lett 126:131–133PubMedGoogle Scholar
  30. Bolser DC, DeGennaro FC, O'Reilly S, McLeod RL, Hey JA (1997) Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat. Br J Pharmacol 121:165–170PubMedGoogle Scholar
  31. Bond RA, Spina D, Parra S, Page CP (2007) Getting to the heart of asthma: can “beta blockers” be useful to treat asthma? Pharmacol Ther 115:360–374PubMedGoogle Scholar
  32. Bonham AC, Joad JP (1991) Neurones in commissural nucleus tractus solitarii required for full expression of the pulmonary C fibre reflex in rat. J Physiol 441:95–112PubMedGoogle Scholar
  33. Bonham AC, McCrimmon DR (1990) Neurones in a discrete region of the nucleus tractus solitarius are required for the Breuer-Hering reflex in rat. J Physiol 427:261–280PubMedGoogle Scholar
  34. Bonham AC, Coles SK, McCrimmon DR (1993) Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats. J Physiol 464:725–745PubMedGoogle Scholar
  35. Bonham AC, Kott KS, Ravi K, Kappagoda CT, Joad JP (1996) Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits. J Physiol 493(Pt 1):229–238PubMedGoogle Scholar
  36. Bootle DJ, Adcock JJ, Ramage AG (1996) Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled capsaicin in anaesthetized cats. Br J Pharmacol 117:724–728PubMedGoogle Scholar
  37. Boushey HA, Richardson PS, Widdicombe JG, Wise JC (1974) The response of laryngeal afferent fibres to mechanical and chemical stimuli. J Physiol Lond 240:153–175PubMedGoogle Scholar
  38. Bramley AM, Samhoun MN, Piper PJ (1990) The role of the epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro. Br J Pharmacol 99:762–766PubMedGoogle Scholar
  39. Burki NK, Dale WJ, Lee LY (2005) Intravenous adenosine and dyspnea in humans. J Appl Physiol 98:180–185PubMedGoogle Scholar
  40. Canning BJ (2006) Reflex regulation of airway smooth muscle tone. J Appl Physiol 101:971–985PubMedGoogle Scholar
  41. Canning BJ (2007) Encoding of the cough reflex. Pulm Pharmacol Ther 20:396–401PubMedGoogle Scholar
  42. Canning BJ, Chou YL (2009) Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough. Handb Exp Pharmacol:23–47Google Scholar
  43. Canning BJ, Undem BJ (1993) Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways. J Physiol 460:719–739PubMedGoogle Scholar
  44. Canning BJ, Reynolds SM, Mazzone SB (2001) Multiple mechanisms of reflex bronchospasm in guinea pigs. J Appl Physiol 91:2642–2653PubMedGoogle Scholar
  45. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557:543–558PubMedGoogle Scholar
  46. Canning BJ, Farmer DG, Mori N (2006a) Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 291:R454–R463PubMedGoogle Scholar
  47. Canning BJ, Mori N, Mazzone SB (2006b) Vagal afferent nerves regulating the cough reflex. Respir Physiol Neurobiol 152:223–242PubMedGoogle Scholar
  48. Carr MJ, Undem BJ (2003) Pharmacology of vagal afferent nerve activity in guinea pig airways. Pulm Pharmacol Ther 16:45–52PubMedGoogle Scholar
  49. Carr MJ, Schechter NM, Undem BJ (2000) Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus. Am J Respir Crit Care Med 162(5):1662–1667PubMedGoogle Scholar
  50. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824PubMedGoogle Scholar
  51. Chanez P, Springall D, Vignola AM, Moradoghi-Hattvani A, Polak JM, Godard P, Bousquet J (1998) Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases. Am J Respir Crit Care Med 158:985–990PubMedGoogle Scholar
  52. Chesrown SE, Venugopalan CS, Gold WM, Drazen JM (1980) In vivo demonstration of nonadrenergic inhibitory innervation of the guinea pig trachea. J Clin Invest 65:314–320PubMedGoogle Scholar
  53. Chianca DA Jr, Machado BH (1996) Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold–Jarisch reflex. Brain Res 718:185–188PubMedGoogle Scholar
  54. Choi JY, Joo NS, Krouse ME, Wu JV, Robbins RC, Ianowski JP, Hanrahan JW, Wine JJ (2007) Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. J Clin Invest 117(10):3118–3127PubMedGoogle Scholar
  55. Chou YL, Scarupa MD, Mori N, Canning BJ (2008) Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 295:R1572–R1584PubMedGoogle Scholar
  56. Chuaychoo B, Lee MG, Kollarik M, Undem BJ (2005) Effect of 5-hydroxytryptamine on vagal C-fiber subtypes in guinea pig lungs. Pulm Pharmacol Ther 18:269–276PubMedGoogle Scholar
  57. Chuaychoo B, Lee MG, Kollarik M, Pullmann R Jr, Undem BJ (2006) Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs. J Physiol 575:481–490PubMedGoogle Scholar
  58. Clark N, Keeble J, Fernandes ES, Starr A, Liang L, Sugden D, de WP, Brain SD (2007) The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin. FASEB J 21:3747–3755PubMedGoogle Scholar
  59. Clerici C, Macquin-Mavier I, Harf A (1989) Nonadrenergic bronchodilation in adult and young guinea pigs. J Appl Physiol 67(5):1764–1769PubMedGoogle Scholar
  60. Coburn RF, Tomita T (1973) Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle. Am J Physiol 224:1072–1080PubMedGoogle Scholar
  61. Cockcroft DW, Davis BE (2006) Mechanisms of airway hyperresponsiveness. J Allergy Clin Immunol 118:551–559PubMedGoogle Scholar
  62. Coleridge HM, Coleridge JC (1977) Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs. Respir Physiol 29:125–142PubMedGoogle Scholar
  63. Coleridge JC, Coleridge HM (1984) Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 99:1–110PubMedGoogle Scholar
  64. Coleridge HM, Coleridge JC, Banzett RB (1978) II. Effect of CO2 on afferent vagal endings in the canine lung. Respir Physiol 34:135–151PubMedGoogle Scholar
  65. Coleridge JC, Coleridge HM, Roberts AM, Kaufman MP, Baker DG (1982) Tracheal contraction and relaxation initiated by lung and somatic afferents in dogs. J Appl Physiol 52:984–990PubMedGoogle Scholar
  66. Cortright DN, Krause JE, Broom DC (2007) TRP channels and pain. Biochim Biophys Acta 1772:978–988PubMedGoogle Scholar
  67. Coyle AJ, Perretti F, Manzini S, Irvin CG (1994) Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation. J Clin Invest 94:2301–2306PubMedGoogle Scholar
  68. Daffonchio L, Hernandez A, Gallico L, Omini C (1990) Airway hyperreactivity induced by active cigarette smoke exposure in guinea-pigs: possible role of sensory neuropeptides. Pulm Pharmacol 3:161–166PubMedGoogle Scholar
  69. Davies RO, Kubin L (1986) Projection of pulmonary rapidly adapting receptors to the medulla of the cat: an antidromic mapping study. J Physiol 373:63–86PubMedGoogle Scholar
  70. Davies A, Dixon M, Callanan D, Huszczuk A, Widdicombe JG, Wise JC (1978) Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide. Respir Physiol 34:83–101PubMedGoogle Scholar
  71. Davies RO, Kubin L, Pack AI (1987a) Pulmonary stretch receptor relay neurones of the cat: location and contralateral medullary projections. J Physiol 383:571–585PubMedGoogle Scholar
  72. Davies SF, McQuaid KR, Iber C, McArthur CD, Path MJ, Beebe DS, Helseth HK (1987b) Extreme dyspnea from unilateral pulmonary venous obstruction. Demonstration of a vagal mechanism and relief by right vagotomy. Am Rev Respir Dis 136(1):184–188PubMedGoogle Scholar
  73. Davis KD, Meyer RA, Turnquist JL, Filloon TG, Pappagallo M, Campbell JN (1995) Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia. Pain 62:373–378PubMedGoogle Scholar
  74. Deep V, Singh M, Ravi K (2001) Role of vagal afferents in the reflex effects of capsaicin and lobeline in monkeys. Respir Physiol 125:155–168PubMedGoogle Scholar
  75. Delpierre S, Grimaud C, Jammes Y, Mei N (1981) Changes in activity of vagal bronchopulmonary C fibres by chemical and physical stimuli in the cat. J Physiol 316:61–74PubMedGoogle Scholar
  76. De Proost I, Pintelon I, Brouns I, Timmermans JP, Adriaensen D (2007) Selective visualisation of sensory receptors in the smooth muscle layer of ex-vivo airway whole-mounts by styryl pyridinium dyes. Cell Tissue Res 329:421–431PubMedGoogle Scholar
  77. De Swert KO, Joos GF (2006) Extending the understanding of sensory neuropeptides. Eur J Pharmacol 533:171–181PubMedGoogle Scholar
  78. Dey RD, Altemus JB, Zervos I, Hoffpauir J (1990) Origin and colocalization of CGRP- and SP-reactive nerves in cat airway epithelium. J Appl Physiol 68:770–778PubMedGoogle Scholar
  79. Diamond L, O'Donnell M (1980) A nonadrenergic vagal inhibitory pathway to feline airways. Science 208:185–188PubMedGoogle Scholar
  80. Dicpinigaitis PV (2007) Experimentally induced cough. Pulm Pharmacol Ther 20:319–24PubMedGoogle Scholar
  81. Dinh QT, Groneberg DA, Peiser C, Mingomataj E, Joachim RA, Witt C, Arck PC, Klapp BF, Fischer A (2004) Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung. Respir Physiol Neurobiol 144(1):15–24PubMedGoogle Scholar
  82. Dixon M, Jackson DM, Richards IM (1979) The effects of histamine, acetylcholine and 5-hydroxytryptamine on lung mechanics and irritant receptors in the dog. J Physiol 287:393–403PubMedGoogle Scholar
  83. Dixon M, Jackson DM, Richards IM (1980) The action of sodium cromoglycate on ‘C' fibre endings in the dog lung. Br J Pharmacol 70:11–13PubMedGoogle Scholar
  84. Dybas JM, Andresen CJ, Schelegle ES, McCue RW, Callender NN, Jackson AC (2006) Deep-breath frequency in bronchoconstricted monkeys (Macaca fascicularis). J Appl Physiol 100:786–791PubMedGoogle Scholar
  85. Ellis JL, Sham JS, Undem BJ (1997) Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi. Am J Respir Crit Care Med 155:751–755PubMedGoogle Scholar
  86. Ezure K, Otake K, Lipski J, She RB (1991) Efferent projections of pulmonary rapidly adapting receptor relay neurons in the cat. Brain Res 564:268–278PubMedGoogle Scholar
  87. Ezure K, Tanaka I, Miyazaki M (1999) Electrophysiological and pharmacological analysis of synaptic inputs to pulmonary rapidly adapting receptor relay neurons in the rat. Exp Brain Res 128:471–480PubMedGoogle Scholar
  88. Ezure K, Tanaka I, Saito Y, Otake K (2002) Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat. J Comp Neurol 446:81–94PubMedGoogle Scholar
  89. Fischer A, Forssmann WG, Undem BJ (1998) Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus. J Pharmacol Exp Ther 285:902–907PubMedGoogle Scholar
  90. Fisher JT, Sant'Ambrogio G (1982) Effects of inhaled CO2 on airway stretch receptors in the newborn dog. J Appl Physiol 53(6):1461–1465PubMedGoogle Scholar
  91. Forsberg K, Karlsson JA, Theodorsson E, Lundberg JM, Persson CG (1988) Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol 1:33–39PubMedGoogle Scholar
  92. Fox AJ, Barnes PJ, Urban L, Dray A (1993) An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol 469:21–35PubMedGoogle Scholar
  93. Fox AJ, Barnes PJ, Dray A (1995) Stimulation of guinea-pig tracheal afferent fibres by non-isosmotic and low-chloride stimuli and the effect of frusemide. J Physiol 482(Pt 1):179–187PubMedGoogle Scholar
  94. Fox AJ, Barnes PJ, Venkatesan P, Belvisi MG (1997) Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. J Clin Invest 99:513–519PubMedGoogle Scholar
  95. Gatti R, Andre E, Amadesi S, Dinh TQ, Fischer A, Bunnett NW, Harrison S, Geppetti P, Trevisani M (2006) Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs. J Appl Physiol 101:506–511PubMedGoogle Scholar
  96. Gaylor JB (1934) The intrinsic nervous mechanism of the human lung. Brain 57:143–160Google Scholar
  97. Geppetti P, Trevisani M (2004) Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol 141:1313–1320PubMedGoogle Scholar
  98. Gestreau C, Bianchi AL, Grelot L (1997) Differential brainstem fos-like immunoreactivity after laryngeal-induced coughing and its reduction by codeine. J Neurosci 17:9340–9352PubMedGoogle Scholar
  99. Gil FR, Lauzon AM (2007) Smooth muscle molecular mechanics in airway hyperresponsiveness and asthma. Can J Physiol Pharmacol 85:133–140PubMedGoogle Scholar
  100. Girard V, Yavo JC, Emonds-Alt X, Advenier C (1996) The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea-pigs. Am J Respir Crit Care Med 153:1496–1502PubMedGoogle Scholar
  101. Giuliani S, Amann R, Papini AM, Maggi CA, Meli A (1989) Modulatory action of galanin on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves. Eur J Pharmacol 163:91–96PubMedGoogle Scholar
  102. Glaser ST, Kaczocha M, Deutsch DG (2005) Anandamide transport: a critical review. Life Sci 77:1584–1604PubMedGoogle Scholar
  103. Green JF, Schmidt ND, Schultz HD, Roberts AM, Coleridge HM, Coleridge JC (1984) Pulmonary C-fibers evoke both apnea and tachypnea of pulmonary chemoreflex. J Appl Physiol 57(2): 562–567PubMedGoogle Scholar
  104. Green JF, Schertel ER, Coleridge HM, Coleridge JC (1986) Effect of pulmonary arterial PCO2 on slowly adapting pulmonary stretch receptors. J Appl Physiol 60:2048–2055PubMedGoogle Scholar
  105. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF (2004) Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170:1276–1280PubMedGoogle Scholar
  106. Gross NJ, Co E, Skorodin MS (1989) Cholinergic bronchomotor tone in COPD. Estimates of its amount in comparison with that in normal subjects. Chest 96:984–987PubMedGoogle Scholar
  107. Grundstrom N, Andersson RG, Wikberg JE (1981) Prejunctional alpha 2 adrenoceptors inhibit contraction of tracheal smooth muscle by inhibiting cholinergic neurotransmission. Life Sci 28:2981–2986PubMedGoogle Scholar
  108. Grundstrom N, Andersson RG, Wikberg JE (1984) Inhibition of the excitatory non-adrenergic, non-cholinergic neurotransmission in the guinea pig tracheo-bronchial tree mediated by alpha 2-adrenoceptors. Acta Pharmacol Toxicol (Copenh) 54:8–14Google Scholar
  109. Gu Q, Lee LY (2006) Characterization of acid signaling in rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 291:L58–L65PubMedGoogle Scholar
  110. Gu Q, Lin YS, Lee LY (2007) Epinephrine enhances the sensitivity of rat vagal chemosensitive neurons: role of beta3-adrenoceptor. J Appl Physiol 102:1545–1555PubMedGoogle Scholar
  111. Gu Q, Ni D, Lee LY (2008) Expression of neuronal nicotinic acetylcholine receptors in rat vagal pulmonary sensory neurons. Respir Physiol Neurobiol 161:87–91PubMedGoogle Scholar
  112. Guardiola J, Proctor M, Li H, Punnakkattu R, Lin S, Yu J (2007) Airway mechanoreceptor deactivation. J Appl Physiol 103:600–607PubMedGoogle Scholar
  113. Gunthorpe MJ, Benham CD, Randall A, Davis JB (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci 23:183–191PubMedGoogle Scholar
  114. Guo A, Vulchanova L, Wang J, Li X, Elde R (1999) Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11:946–958PubMedGoogle Scholar
  115. Habler HJ, Janig W, Michaelis M (1994) Respiratory modulation in the activity of sympathetic neurones. Prog Neurobiol 43:567–606PubMedGoogle Scholar
  116. Hammad H, Lambrecht BN (2007) Lung dendritic cell migration. Adv Immunol 93:265–278PubMedGoogle Scholar
  117. Hanacek J, Davies A, Widdicombe JG (1984) Influence of lung stretch receptors on the cough reflex in rabbits. Respiration 45:161–168PubMedGoogle Scholar
  118. Harrison S, Reddy S, Page CP, Spina D (1998) Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus. Br J Pharmacol 125:1405–1412PubMedGoogle Scholar
  119. Haxhiu MA, Chavez JC, Pichiule P, Erokwu B, Dreshaj IA (2000) The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion. Brain Res 883:77–86PubMedGoogle Scholar
  120. Helyes Z, Elekes K, Nemeth J, Pozsgai G, Sandor K, Kereskai L, Borzsei R, Pinter E, Szabo A, Szolcsanyi J (2007) Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse. Am J Physiol Lung Cell Mol Physiol 292:L1173–L1181PubMedGoogle Scholar
  121. Hempleman SC, Rodriguez TA, Bhagat YA, Begay RS (2000) Benzolamide, acetazolamide, and signal transduction in avian intrapulmonary chemoreceptors. Am J Physiol Regul Integr Comp Physiol 279:R1988–R1995PubMedGoogle Scholar
  122. Herd CM, Gozzard N, Page CP (1995) Capsaicin pretreatment prevents the development of antigen induced airway hyperresponsiveness in neonatally immunized rabbits. Eur J Pharmacol 282:111–119PubMedGoogle Scholar
  123. Hislop AA, Wharton J, Allen KM, Polak JM, Haworth SG (1990) Immunohistochemical localization of peptide-containing nerves in human airways: age-related changes. Am J Respir Cell Mol Biol 3:191–198PubMedGoogle Scholar
  124. Ho CY, Gu Q, Hong JL, Lee LY (2000) Prostaglandin E(2) enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat. Am J Respir Crit Care Med 162:528–533PubMedGoogle Scholar
  125. Ho CY, Gu Q, Lin YS, Lee LY (2001) Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 127:113–124PubMedGoogle Scholar
  126. Holgate ST (2007) The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol 28:248–251PubMedGoogle Scholar
  127. Hong JL, Ho CY, Kwong K, Lee LY (1998) Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors. J Physiol 508 (Pt 1):109–118PubMedGoogle Scholar
  128. Hornby PJ (2001) Central neurocircuitry associated with emesis. Am J Med 111(Suppl 8A): 106S–112SPubMedGoogle Scholar
  129. House A, Celly C, Skeans S, Lamca J, Egan RW, Hey JA, Chapman RW (2004) Cough reflex in allergic dogs. Eur J Pharmacol 492:251–258Google Scholar
  130. Howarth PH, Springall DR, Redington AE, Djukanovic R, Holgate ST, Polak JM (1995) Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects. Am J Respir Cell Mol Biol 13:288–296PubMedGoogle Scholar
  131. Hua XY, Yaksh TL (1992) Release of calcitonin gene-related peptide and tachykinins from the rat trachea. Peptides 13(1):113–120PubMedGoogle Scholar
  132. Hua XY, Theodorsson-Norheim E, Brodin E, Lundberg JM, Hokfelt T (1985) Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig. Regul Pept 13:1–19PubMedGoogle Scholar
  133. Huang WX, Yu Q, Cohen MI (2000) Fast (3 Hz and 10 Hz) and slow (respiratory) rhythms in cervical sympathetic nerve and unit discharges of the cat. J Physiol 523(Pt 2):459–477PubMedGoogle Scholar
  134. Hunter DD, Undem BJ (1999) Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea. Am J Respir Crit Care Med 159:1943–1948PubMedGoogle Scholar
  135. Hutter MM, Wick EC, Day AL, Maa J, Zerega EC, Richmond AC, Jordan TH, Grady EF, Mulvihill SJ, Bunnett NW, Kirkwood KS (2005) Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R). Pancreas 30:260–265PubMedGoogle Scholar
  136. Ichinose M, Inoue H, Miura M, Yafuso N, Nogami H, Takishima T (1987) Possible sensory receptor of nonadrenergic inhibitory nervous system. J Appl Physiol 63:923–929PubMedGoogle Scholar
  137. Ichinose M, Inoue H, Miura M, Takishima T (1988) Nonadrenergic bronchodilation in normal subjects. Am Rev Respir Dis 138:31–34PubMedGoogle Scholar
  138. Inoue H, Ichinose M, Miura M, Katsumata U, Takishima T (1989) Sensory receptors and reflex pathways of nonadrenergic inhibitory nervous system in feline airways. Am Rev Respir Dis 139(5):1175–1178PubMedGoogle Scholar
  139. Inoue H, Aizawa H, Miyazaki N, Ikeda T, Shigematsu N (1991) Possible roles of the peripheral vagal nerve in histamine-induced bronchoconstriction in guinea-pigs. Eur Respir J 4:860–866PubMedGoogle Scholar
  140. Irvin CG, Martin RR, Macklem PT (1982) Nonpurinergic nature and efficacy of nonadrenergic bronchodilation. J Appl Physiol 52:562–569PubMedGoogle Scholar
  141. Jackson DM, Norris AA, Eady RP (1989) Nedocromil sodium and sensory nerves in the dog lung. Pulm Pharmacol 2:179–184PubMedGoogle Scholar
  142. Jacobsen EA, Ochkur SI, Lee NA, Lee JJ (2007) Eosinophils and asthma. Curr Allergy Asthma Rep 7:18–26PubMedGoogle Scholar
  143. Jakus J, Poliacek I, Halasova E, Murin P, Knocikova J, Tomori Z, Bolser DC (2008) Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats. Respir Physiol Neurobiol 160:289–300PubMedGoogle Scholar
  144. Jammes Y, Mei N (1979) Assessment of the pulmonary origin of bronchoconstrictor vagal tone. J Physiol 291:305–316PubMedGoogle Scholar
  145. Janig W, Habler HJ (2003) Neurophysiological analysis of target-related sympathetic pathways--from animal to human: similarities and differences. Acta Physiol Scand 177:255–274PubMedGoogle Scholar
  146. Jarreau PH, D'Ortho MP, Boyer V, Harf A, quin Mavier I (1994) Effects of capsaicin on the airway responses to inhaled endotoxin in the guinea pig. Am J Respir Crit Care Med 149:128–133PubMedGoogle Scholar
  147. Jia Y, Lee LY (2007) Role of TRPV receptors in respiratory diseases. Biochim Biophys Acta 1772:915–927PubMedGoogle Scholar
  148. Jia Y, McLeod RL, Wang X, Parra LE, Egan RW, Hey JA (2002) Anandamide induces cough in conscious guinea-pigs through VR1 receptors. Br J Pharmacol 137:831–836PubMedGoogle Scholar
  149. Jimba M, Skornik WA, Killingsworth CR, Long NC, Brain JD, Shore SA (1995) Role of C fibers in physiological responses to ozone in rats. J Appl Physiol 78:1757–1763PubMedGoogle Scholar
  150. Jonzon A, Pisarri TE, Coleridge JC, Coleridge HM (1986) Rapidly adapting receptor activity in dogs is inversely related to lung compliance. J Appl Physiol 61:1980–1987PubMedGoogle Scholar
  151. Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203–210PubMedGoogle Scholar
  152. Kalia M, Richter D (1985) Morphology of physiologically identified slowly adapting lung stretch receptor afferents stained with intra-axonal horseradish peroxidase in the nucleus of the tractus solitarius of the cat. I. A light microscopic analysis. J Comp Neurol 241:503–520PubMedGoogle Scholar
  153. Kalia M, Richter D (1988) Rapidly adapting pulmonary receptor afferents: II. Fine structure and synaptic organization of central terminal processes in the nucleus of the tractus solitarius. J Comp Neurol 274:574–594PubMedGoogle Scholar
  154. Kallinich T, Beier KC, Wahn U, Stock P, Hamelmann E (2007) T-cell co-stimulatory molecules: their role in allergic immune reactions. Eur Respir J 29:1246–1255PubMedGoogle Scholar
  155. Kamikawa Y, Shimo Y (1989) Adenosine selectively inhibits noncholinergic transmission in guinea pig bronchi. J Appl Physiol 66:2084–2091PubMedGoogle Scholar
  156. Karius DR, Ling L, Speck DF (1994) Nucleus tractus solitarius and excitatory amino acids in afferent-evoked inspiratory termination. J Appl Physiol 76:1293–1301PubMedGoogle Scholar
  157. Karla W, Shams H, Orr JA, Scheid P (1992) Effects of the thromboxane A2 mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir Physiol 87:383–396PubMedGoogle Scholar
  158. Karlsson JA, Fuller RW (1999) Pharmacological regulation of the cough reflex--from experimental models to antitussive effects in Man. Pulm Pharmacol Ther 12:215–228PubMedGoogle Scholar
  159. Karlsson JA, Sant'Ambrogio FB, Forsberg K, Palecek F, Mathew OP, Sant'Ambrogio G (1993) Respiratory and cardiovascular effects of inhaled and intravenous bradykinin, PGE2, and PGF2 alpha in dogs. J Appl Physiol 74:2380–2386PubMedGoogle Scholar
  160. Kaufman MP, Coleridge HM, Coleridge JC, Baker DG (1980) Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs. J Appl Physiol 48:511–517PubMedGoogle Scholar
  161. Keeble J, Russell F, Curtis B, Starr A, Pinter E, Brain SD (2005) Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. Arthritis Rheum 52:3248–3256PubMedGoogle Scholar
  162. Kesler BS, Canning BJ (1999) Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle. J Physiol 518 (Pt 3):843–855PubMedGoogle Scholar
  163. Kesler BS, Mazzone SB, Canning BJ (2002) Nitric oxide-dependent modulation of smooth-muscle tone by airway parasympathetic nerves. Am J Respir Crit Care Med 165:481–488PubMedGoogle Scholar
  164. Ketchell RI, Jensen MW, Lumley P, Wright AM, Allenby MI, O'Connor BJ (2002) Rapid effect of inhaled fluticasone propionate on airway responsiveness to adenosine 5′-monophosphate in mild asthma. J Allergy Clin Immunol 110:603–606PubMedGoogle Scholar
  165. Kihara N, de la Fuente SG, Fujino K, Takahashi T, Pappas TN, Mantyh CR (2003) Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. Gut 52:713–719PubMedGoogle Scholar
  166. Knowlton GC, Larrabee MG (1946) A unitary analysis of pulmonary volume receptors. Am J Physiol Lung Cell Mol Physiol 147:100–114Google Scholar
  167. Kollarik M, Undem BJ (2002) Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig. J Physiol 543:591–600PubMedGoogle Scholar
  168. Kollarik M, Undem BJ (2004) Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1−/− mice. J Physiol 555:115–123PubMedGoogle Scholar
  169. Kollarik M, Dinh QT, Fischer A, Undem BJ (2003) Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse. J Physiol 551:869–879PubMedGoogle Scholar
  170. Kollarik M, Ru F, Undem BJ (2007) Acid-sensitive vagal sensory pathways and cough. Pulm Pharmacol Ther 20:402–411PubMedGoogle Scholar
  171. Koto H, Aizawa H, Takata S, Inoue H, Hara N (1995) An important role of tachykinins in ozone-induced airway hyperresponsiveness. Am J Respir Crit Care Med 151:1763–1769PubMedGoogle Scholar
  172. Kubin L, Kimura H, Davies RO (1991) The medullary projections of afferent bronchopulmonary C fibres in the cat as shown by antidromic mapping. J Physiol 435:207–228PubMedGoogle Scholar
  173. Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR (2006) Central pathways of pulmonary and lower airway vagal afferents. J Appl Physiol 101:618–627PubMedGoogle Scholar
  174. Kummer W, Fischer A, Kurkowski R, Heym C (1992) The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry. Neuroscience 49:715–737PubMedGoogle Scholar
  175. Kwong K, Hong JL, Morton RF, Lee LY (1998) Role of pulmonary C fibres in adenosine-induced respiratory inhibition in anesthetized rats. J Appl Physiol 84:417–424PubMedGoogle Scholar
  176. Kwong K, Carr MJ, Gibbard A, Savage TJ, Singh K, Jing J, Meeker S, Undem BJ (2008a) Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs. J Physiol 586:1321–1336PubMedGoogle Scholar
  177. Kwong K, Kollarik M, Nassenstein C, Ru F, Undem BJ (2008b) P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus. Am J Physiol Lung Cell Mol Physiol 295:L858–L865PubMedGoogle Scholar
  178. Lacroix JS, Buvelot JM, Polla BS, Lundberg JM (1991) Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy 21:595–600PubMedGoogle Scholar
  179. Lai CJ, Ruan T, Kou YR (2005) The involvement of hydroxyl radical and cyclooxygenase metabolites in the activation of lung vagal sensory receptors by circulatory endotoxin in rats. J Appl Physiol 98:620–628PubMedGoogle Scholar
  180. Laitinen LA, Laitinen A, Panula PA, Partanen M, Tervo K, Tervo T (1983) Immunohistochemical demonstration of substance P in the lower respiratory tract of the rabbit and not of man. Thorax 38:531–536PubMedGoogle Scholar
  181. Lalloo UG, Fox AJ, Belvisi MG, Chung KF, Barnes PJ (1995) Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol 79:1082–1087PubMedGoogle Scholar
  182. Lama A, Delpierre S, Jammes Y (1988) The effects of electrical stimulation of myelinated and non-myelinated vagal motor fibres on airway tone in the rabbit and the cat. Respir Physiol 74:265–274PubMedGoogle Scholar
  183. Lamb JP, Sparrow MP (2002) Three-dimensional mapping of sensory innervation with substance p in porcine bronchial mucosa: comparison with human airways. Am J Respir Crit Care Med 166:1269–1281PubMedGoogle Scholar
  184. Lammers JW, Minette P, McCusker MT, Chung KF, Barnes PJ (1989) Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system. J Appl Physiol 67(2):856–861PubMedGoogle Scholar
  185. Larsell O (1921) Nerve termination in the lung of the rabbit. J Comp Neurol 33:105–131Google Scholar
  186. Larsell O (1922) The ganglia, plexuses and nerve-termination of the mammalian lung and pleura pulmonis. J Comp Neurol 35:97–132Google Scholar
  187. Laude EA, Higgins KS, Morice AH (1993) A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man. Pulm Pharmacol 6:171–175PubMedGoogle Scholar
  188. Lee LY, Morton RF (1993) Histamine enhances vagal pulmonary C-fiber responses to capsaicin and lung inflation. Respir Physiol 93:83–96PubMedGoogle Scholar
  189. Lee LY, Morton RF (1995) Pulmonary chemoreflex sensitivity is enhanced by prostaglandin E2 in anesthetized rats. J Appl Physiol 79:1679–1686PubMedGoogle Scholar
  190. Lee LY, Pisarri TE (2001) Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 125:47–65PubMedGoogle Scholar
  191. Lee MG, Weinreich D, Undem BJ (2005) Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. Br J Pharmacol 146:596–603PubMedGoogle Scholar
  192. Leung SY, Niimi A, Williams AS, Nath P, Blanc FX, Dinh QT, Chung KF (2007) Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough 3:10PubMedGoogle Scholar
  193. Liddle RA (2007) The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. Biochim Biophys Acta 1772:869–878PubMedGoogle Scholar
  194. Ligresti A, Morera E, Van Der Stelt M, Monory K, Lutz B, Ortar G, Di Marzo V (2004) Further evidence for the existence of a specific process for the membrane transport of anandamide. Biochem J 380:265–272PubMedGoogle Scholar
  195. Lin YS, Lee LY (2002) Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. J Physiol 539:947–955PubMedGoogle Scholar
  196. Lin RL, Gu Q, Lin YS, Lee LY (2005) Stimulatory effect of CO2 on vagal bronchopulmonary C-fiber afferents during airway inflammation. J Appl Physiol 99:1704–1711PubMedGoogle Scholar
  197. Lipski J, Ezure K, Wong She RB (1991) Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat. J Physiol 443:55–77PubMedGoogle Scholar
  198. Lloyd CM, Robinson DS (2007) Allergen-induced airway remodelling. Eur Respir J 29:1020–1032PubMedGoogle Scholar
  199. Loeffler BS, Arden WA, Fiscus RR, Lee LY (1997) Involvement of tachykinins in endotoxin-induced airway hyperresponsiveness. Lung 175:253–263PubMedGoogle Scholar
  200. Long NC, Martin JG, Pantano R, Shore SA (1997) Airway hyperresponsiveness in a rat model of chronic bronchitis: role of C fibers. Am J Respir Crit Care Med 155:1222–1229PubMedGoogle Scholar
  201. Long NC, Abraham J, Kobzik L, Weller EA, Krishna Murthy GG, Shore SA (1999) Respiratory tract inflammation during the induction of chronic bronchitis in rats: role of C-fibres. Eur Respir J 14:46–56PubMedGoogle Scholar
  202. Lundberg JM, Martling CR, Saria A, Folkers K, Rosell S (1983) Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release. Neuroscience 10:1361–1368PubMedGoogle Scholar
  203. Lundberg JM, Hokfelt T, Martling CR, Saria A, Cuello C (1984) Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res 235:251–261PubMedGoogle Scholar
  204. Ma AA, Ravi K, Bravo EM, Kappagoda CT (2004) Effects of gadolinium chloride on slowly adapting and rapidly adapting receptors of the rabbit lung. Respir Physiol Neurobiol 141: 125–135PubMedGoogle Scholar
  205. Ma W, Quirion R (2007) Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain. Expert Opin Ther Targets 11:307–320PubMedGoogle Scholar
  206. Manzini S (1992) Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus. Br J Pharmacol 105(4):968–972PubMedGoogle Scholar
  207. Mapp CE, Boniotti A, Graf PD, Chitano P, Fabbri LM, Nadel JA (1991) Bronchial smooth muscle responses evoked by toluene diisocyanate are inhibited by ruthenium red and by indomethacin. Eur J Pharmacol 200:73–76PubMedGoogle Scholar
  208. Marek W, Potthast JJW, Marczynski B, Baur X (1996) Role of substance P and neurokinin A in toluene diisocyanate- induced increased airway responsiveness in rabbits. Lung 174:83–97PubMedGoogle Scholar
  209. Martling CR (1987) Sensory nerves containing tachykinins and CGRP in the lower airways. Functional implications for bronchoconstriction, vasodilatation and protein extravasation. Acta Physiol Scand Suppl 563:1–57PubMedGoogle Scholar
  210. Massa F, Sibaev A, Marsicano G, Blaudzun H, Storr M, Lutz B (2006) Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis. J Mol Med 84:142–146PubMedGoogle Scholar
  211. Matran R, Martling CR, Lundberg JM (1989) Inhibition of cholinergic and non-adrenergic, non-cholinergic bronchoconstriction in the guinea pig mediated by neuropeptide Y and alpha 2-adrenoceptors and opiate receptors. Eur J Pharmacol 163:15–23PubMedGoogle Scholar
  212. Matsumoto S (1996) Effects of vagal stimulation on slowly adapting pulmonary stretch receptors and lung mechanics in anesthetized rabbits. Lung 174:333–344PubMedGoogle Scholar
  213. Matsumoto S (1998) Effects of sustained constant artificial ventilation on rapidly adapting pulmonary stretch receptors and lung mechanics in rabbits. Life Sci 62(4):319–325PubMedGoogle Scholar
  214. Matsumoto S, Shimizu T (1989) Effects of 5-hydroxytryptamine on rapidly adapting pulmonary stretch receptor activity in the rabbit. J Auton Nerv Syst 27:35–38PubMedGoogle Scholar
  215. Matsumoto N, Inoue H, Ichinose M, Ishii M, Inoue C, Sasaki H, Takishima T (1985) Effective sites by sympathetic beta-adrenergic and vagal nonadrenergic inhibitory stimulation in constricted airways. Am Rev Respir Dis 132:1113–1117PubMedGoogle Scholar
  216. Matsumoto S, Okamura H, Suzuki K, Sugai N, Shimizu T (1996) Inhibitory mechanism of CO2 inhalation on slowly adapting pulmonary stretch receptors in the anesthetized rabbit. J Pharmacol Exp Ther 279(1):402–409PubMedGoogle Scholar
  217. Matsumoto S, Takeda M, Saiki C, Takahashi T, Ojima K (1997) Effects of vagal and carotid chemoreceptor afferents on the frequency and pattern of spontaneous augmented breaths in rabbits. Lung 175:175–186.Google Scholar
  218. Matsumoto S, Takahashi T, Tanimoto T, Saiki C, Takeda M, Ojima K (1998) Excitatory mechanism of veratridine on slowly adapting pulmonary stretch receptors in anesthetized rabbits. Life Sci 63:1431–1437PubMedGoogle Scholar
  219. Matsumoto S, Takahashi T, Tanimoto T, Saiki C, Takeda M (1999) Effects of potassium channel blockers on CO2-induced slowly adapting pulmonary stretch receptor inhibition. J Pharmacol Exp Ther 290:974–979PubMedGoogle Scholar
  220. Matsumoto S, Ikeda M, Nishikawa T (2000) Effects of sodium and potassium channel blockers on hyperinflation-induced slowly adapting pulmonary stretch receptor stimulation in the rat. Life Sci 67:2167–2175PubMedGoogle Scholar
  221. Matsumoto S, Ikeda M, Yoshida S, Nishikawa T, Itoh Y, Fujimi Y, Tanimoto T, Saiki C, Takeda M (2005) The inhibitory effect of ouabain on the response of slowly adapting pulmonary stretch receptors to hyperinflation in the rabbit. Life Sci 78:112–120PubMedGoogle Scholar
  222. Matsumoto S, Saiki C, Yoshida S, Takeda M, Kumagai Y (2006) Effect of ouabain on the afterhyperpolarization of slowly adapting pulmonary stretch receptors in the rat lung. Brain Res 1107:131–139PubMedGoogle Scholar
  223. Matsuse T, Thomson RJ, Chen XR, Salari H, Schellenberg RR (1991) Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. Am Rev Respir Dis 144:368–372PubMedGoogle Scholar
  224. Mazzone SB, Canning BJ (2002a) Evidence for differential reflex regulation of cholinergic and noncholinergic parasympathetic nerves innervating the airways. Am J Respir Crit Care Med 165(8):1076–1083PubMedGoogle Scholar
  225. Mazzone SB, Canning BJ (2002b) Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol Regul Integr Comp Physiol 283:R86–R98PubMedGoogle Scholar
  226. Mazzone SB, Geraghty DP (1999) Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors. Br J Pharmacol 127:473–481PubMedGoogle Scholar
  227. Mazzone SB, McGovern AE (2006) Na+−K+−2Cl cotransporters and Cl channels regulate citric acid cough in guinea pigs. J Appl Physiol 101:635–643PubMedGoogle Scholar
  228. Mazzone SB, McGovern AE (2008) Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs. Cough 4:9PubMedGoogle Scholar
  229. Mazzone SB, Mori N, Canning BJ (2005) Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 569:559–573PubMedGoogle Scholar
  230. McAlexander MA, Undem BJ (2000) Potassium channel blockade induces action potential generation in guinea-pig airway vagal afferent neurones. J Auton Nerv Syst 78:158–164PubMedGoogle Scholar
  231. McAlexander MA, Myers AC, Undem BJ (1998) Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. J Pharmacol Exp Ther 285:602–607PubMedGoogle Scholar
  232. McDonald DM, Mitchell RA, Gabella G, Haskell A (1988) Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability. J Neurocytol 17:605–628PubMedGoogle Scholar
  233. Meyers JR, MacDonald RB, Duggan A, Lenzi D, Standaert DG, Corwin JT, Corey DP (2003) Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci 23:4054–4065PubMedGoogle Scholar
  234. Michoud MC, Amyot R, Jeanneret-Grosjean A, Couture J (1987) Reflex decrease of histamine-induced bronchoconstriction after laryngeal stimulation in humans. Am Rev Respir Dis 136:618–622PubMedGoogle Scholar
  235. Mills JE, Sellick H, Widdicombe JG (1969) Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions. J Physiol 203: 337–357PubMedGoogle Scholar
  236. Mills JE, Sellick H, Widdicombe JG (1970) Epithelial irritant receptors in the lungs. In: Ruth P (ed) Breathing: Hering–Breuer Centenary Symposium. J. & A. Churchill, London, pp 77–99Google Scholar
  237. Miserocchi G, Sant'Ambrogio G (1974) Responses of pulmonary stretch receptors to static pressure inflations. Respir Physiol 21:77–85PubMedGoogle Scholar
  238. Miura M, Inoue H, Ichinose M, Kimura K, Katsumata U, Takishima T (1990) Effect of nonadrenergic noncholinergic inhibitory nerve stimulation on the allergic reaction in cat airways. Am Rev Respir Dis 141:29–32PubMedGoogle Scholar
  239. Mizrahi J, D'Orleans-Juste P, Caranikas S, Regoli D (1982) Effects of peptides and amines on isolated guinea pig tracheae as influenced by inhibitors of the metabolism of arachidonic acid. Pharmacology 25:320–326PubMedGoogle Scholar
  240. Mohammed SP, Higenbottam TW, Adcock JJ (1993) Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats. J Physiol Lond 469:51–66PubMedGoogle Scholar
  241. Moreaux B, Nemmar A, Vincke G, Halloy D, Beerens D, Advenier C, Gustin P (2000) Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs. Eur J Pharmacol 408:305–312PubMedGoogle Scholar
  242. Morikawa T, Gallico L, Widdicombe J (1997) Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig. Pharmacol Res 35:113–118PubMedGoogle Scholar
  243. Morrison SF (2001) Differential control of sympathetic outflow. Am J Physiol Regul Integr Comp Physiol 281:R683–R698PubMedGoogle Scholar
  244. Mutoh T, Joad JP, Bonham AC (2000) Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guinea-pigs. J Physiol 523(Pt 1):223–233PubMedGoogle Scholar
  245. Mutolo D, Bongianni F, Fontana GA, Pantaleo T (2007) The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit. Brain Res Bull 74:284–293PubMedGoogle Scholar
  246. Mutolo D, Bongianni F, Cinelli E, Fontana GA, Pantaleo T (2008) Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. Am J Physiol Regul Integr Comp Physiol 295:R243–R251PubMedGoogle Scholar
  247. Myers AC, Kajekar R, Undem BJ (2002) Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 282:L775–L781PubMedGoogle Scholar
  248. Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, Braun A, Undem BJ (2008) Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586:1595–1604PubMedGoogle Scholar
  249. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165–217PubMedGoogle Scholar
  250. Nishino T (2000) Physiological and pathophysiological implications of upper airway reflexes in humans. Jpn J Physiol 50:3–14PubMedGoogle Scholar
  251. Nohr D, Weihe E (1991) Tachykinin-, calcitonin gene-related peptide-, and protein gene product 9.5-immunoreactive nerve fibers in alveolar walls of mammals. Neurosci Lett 134:17–20PubMedGoogle Scholar
  252. O’Connor BJ, Crowther SD, Costello JF, Morley J (1999) Selective airway responsiveness in asthma. Trends Pharmacol Sci 20:9–11PubMedGoogle Scholar
  253. Oh EJ, Mazzone SB, Canning BJ, Weinreich D (2006) Reflex regulation of airway sympathetic nerves in guinea-pigs. J Physiol 573:549–564PubMedGoogle Scholar
  254. Ohi Y, Yamazaki H, Takeda R, Haji A (2005) Functional and morphological organization of the nucleus tractus solitarius in the fictive cough reflex of guinea pigs. Neurosci Res 53:201–209PubMedGoogle Scholar
  255. Ohi Y, Kato F, Haji A (2007) Codeine presynaptically inhibits the glutamatergic synaptic transmission in the nucleus tractus solitarius of the guinea pig. Neuroscience 146(3):1425–1433PubMedGoogle Scholar
  256. Okajima K, Harada N (2006) Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications. Curr Med Chem 13:2241–2251PubMedGoogle Scholar
  257. Otake K, Ezure K, Lipski J, Wong She RB (1992) Projections from the commissural subnucleus of the nucleus of the solitary tract: an anterograde tracing study in the cat. J Comp Neurol 324:365–378PubMedGoogle Scholar
  258. Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159–227PubMedGoogle Scholar
  259. Palecek F, Sant'Ambrogio G, Sant'Ambrogio FB, Mathew OP (1989) Reflex responses to capsaicin: intravenous, aerosol, and intratracheal administration. J Appl Physiol 67:1428–1437PubMedGoogle Scholar
  260. Paton JF (1998) Pattern of cardiorespiratory afferent convergence to solitary tract neurons driven by pulmonary vagal C-fiber stimulation in the mouse. J Neurophysiol 79:2365–2373PubMedGoogle Scholar
  261. Pedersen KE, Meeker SN, Riccio MM, Undem BJ (1998) Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline. J Appl Physiol 84:499–506PubMedGoogle Scholar
  262. Perretti F, Manzini S (1993) Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs. Am Rev Respir Dis 148:927–931PubMedGoogle Scholar
  263. Pisarri TE, Jonzon A, Coleridge HM, Coleridge JC (1992) Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J Appl Physiol 73:2305–2313PubMedGoogle Scholar
  264. Polosa R, Renaud L, Cacciola R, Prosperini G, Crimi N, Djukanovic R (1998) Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma. Eur Respir J 12:551–556PubMedGoogle Scholar
  265. Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, Cherniack NS, von Euler C (1987) Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol Scand 131:63–71PubMedGoogle Scholar
  266. Proud D, Reynolds CJ, Lacapra S, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM (1988) Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat. Am Rev Respir Dis 137(3):613–616PubMedGoogle Scholar
  267. Ravi K (1985) Effect of carbon dioxide on the activity of slowly and rapidly adapting pulmonary stretch receptors in cats. J Auton Nerv Syst 12:267–277PubMedGoogle Scholar
  268. Ravi K, Kappagoda CT (1992) Responses of pulmonary C-fibre and rapidly adapting receptor afferents to pulmonary congestion and edema in dogs. Can J Physiol Pharmacol 70:68–76PubMedGoogle Scholar
  269. Reynolds CJ, Togias A, Proud D (2002) Airways hyper-responsiveness to bradykinin and methacholine: effects of inhaled fluticasone. Clin Exp Allergy 32:1174–1179PubMedGoogle Scholar
  270. Reynolds SM, Docherty R, Robbins J, Spina D, Page CP (2008) Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism. J Appl Physiol 105:187–196PubMedGoogle Scholar
  271. Ricciardolo FL, Steinhoff M, Amadesi S, Guerrini R, Tognetto M, Trevisani M, Creminon C, Bertrand C, Bunnett NW, Fabbri LM, Salvadori S, Geppetti P (2000) Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways. Am J Respir Crit Care Med 161:1672–1680PubMedGoogle Scholar
  272. Riccio MM, Manzini S, Page CP (1993) The effect of neonatal capsaicin on the development of bronchial hyperresponsiveness in allergic rabbits. Eur J Pharmacol 232:89–97PubMedGoogle Scholar
  273. Riccio MM, Matsumoto T, Adcock JJ, Douglas GJ, Spina D, Page CP (1997) The effect of 15-HPETE on airway responsiveness and pulmonary cell recruitment in rabbits. Br J Pharmacol 122:249–256PubMedGoogle Scholar
  274. Ricco MM, Kummer W, Biglari B, Myers AC, Undem BJ (1996) Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways. J Physiol 496(Pt 2): 521–530PubMedGoogle Scholar
  275. Richardson CA, Herbert DA, Mitchell RA (1984) Modulation of pulmonary stretch receptors and airway resistance by parasympathetic efferents. J Appl Physiol 57:1842–1849PubMedGoogle Scholar
  276. Riedel F, Benden C, Philippou S, Streckert HJ, Marek W (1997) Role of sensory neuropeptides in PIV-3-infection-induced airway hyperresponsiveness in guinea pigs. Respiration 64:211–219PubMedGoogle Scholar
  277. Roberts AM, Hahn HL, Schultz HD, Nadel JA, Coleridge HM, Coleridge J (1982) Afferent vagal C-fibres are responsible for the reflex airway constriction and secretion evoked by pulmonary administration of SO2 in dogs. Physiologist 250:226Google Scholar
  278. Roisman GL, Lacronique JG, Desmazes DN, Carre C, Le-Cae A, Dusser DJ (1996) Airway responsiveness to bradykinin is related to eosinophilic inflammation in asthma. Am J Respir Crit Care Med 153:381–390PubMedGoogle Scholar
  279. Rosenberg HF, Phipps S, Foster PS (2007) Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol 119:1303–1310PubMedGoogle Scholar
  280. Ruan T, Lin YS, Lin KS, Kou YR (2005) Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats. J Physiol 565:563–578PubMedGoogle Scholar
  281. Sampson SR, Vidruk EH (1975) Properties of ‘irritant’ receptors in canine lung. Respir Physiol 25:9–22PubMedGoogle Scholar
  282. Sanico AM, Philip G, Lai GK, Togias A (1999) Hyperosmolar saline induces reflex nasal secretions, evincing neural hyperresponsiveness in allergic rhinitis. J Appl Physiol 86: 1202–1210PubMedGoogle Scholar
  283. Sant'Ambrogio FB, Sant'Ambrogio G, Fisher JT (1988) Lung mechanics and activity of slowly adapting airway stretch receptors. Eur Respir J 1:685–690PubMedGoogle Scholar
  284. Saria A, Martling CR, Dalsgaard CJ, Lundberg JM (1985) Evidence for substance P-immunoreactive spinal afferents that mediate bronchoconstriction. Acta Physiol Scand 125:407–414PubMedGoogle Scholar
  285. Schelegle ES, Green JF (2001) An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors. Respir Physiol 125:17–31PubMedGoogle Scholar
  286. Schlemper V, Calixto JB (2002) Mechanisms underlying the contraction induced by bradykinin in the guinea pig epithelium-denuded trachea. Can J Physiol Pharmacol 80:360–367PubMedGoogle Scholar
  287. Sekizawa S, Joad JP, Bonham AC (2003) Substance P presynaptically depresses the transmission of sensory input to bronchopulmonary neurons in the guinea pig nucleus tractus solitarii. J Physiol 552:547–559PubMedGoogle Scholar
  288. Sellick H, Widdicombe JG (1969) The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion. J Physiol 203:359–381PubMedGoogle Scholar
  289. Shah S, Page CP, Spina D (1998) Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway. Br J Pharmacol 125:510–516PubMedGoogle Scholar
  290. Silva-Carvalho L, Paton JF, Rocha I, Goldsmith GE, Spyer KM (1998) Convergence properties of solitary tract neurons responsive to cardiac receptor stimulation in the anesthetized cat. J Neurophysiol 79:2374–2382PubMedGoogle Scholar
  291. Skogvall S, Berglund M, ence-Guzman MF, Svensson K, Jonsson P, Persson CG, Sterner O (2007) Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. Pulm Pharmacol Ther 20:273–280PubMedGoogle Scholar
  292. Slats AM, Janssen K, van SA, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ (2007) Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 176:121–128PubMedGoogle Scholar
  293. Sont JK, Booms P, Bel EH, Vandenbroucke JP, Sterk PJ (1993) The determinants of airway hyperresponsiveness to hypertonic saline in atopic asthma in vivo. Relationship with sub-populations of peripheral blood leucocytes. Clin Exp Allergy 23:678–688PubMedGoogle Scholar
  294. Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ (1999) Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 159:1043–1051PubMedGoogle Scholar
  295. Spina D, Page CP (1996) Airway sensory nerves in asthma – targets for therapy? Pulm Pharmacol 9:1–18PubMedGoogle Scholar
  296. Spina D, Page CP (2002) Pharmacology of airway irritability. Curr Opin Pharmacol 2:264–272PubMedGoogle Scholar
  297. Spina D, McKenniff MG, Coyle AJ, Seeds EA, Tramontana M, Perretti F, Manzini S, Page CP (1991) Effect of capsaicin on PAF-induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit. Br J Pharmacol 103:1268–1274PubMedGoogle Scholar
  298. Spina D, Harrison S, Page CP (1995) Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus. Br J Pharmacol 116:2334–2340PubMedGoogle Scholar
  299. Spina D, Matera MG, Riccio MM, Page CP (1998) A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airway. Life Sci 63:1629–1643PubMedGoogle Scholar
  300. Stone RA, Worsdell YM, Fuller RW, Barnes PJ (1993) Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex. J Appl Physiol 74:396–401PubMedGoogle Scholar
  301. Storr M (2007) TRPV1 in colitis: is it a good or a bad receptor? – a viewpoint. Neurogastroenterol Motil 19:625–629PubMedGoogle Scholar
  302. Stretton CD, Belvisi MG, Barnes PJ (1991) Modulation of neural bronchoconstrictor responses in the guinea pig respiratory tract by vasoactive intestinal peptide. Neuropeptides 18(3):149–157PubMedGoogle Scholar
  303. Sudo T, Hayashi F, Nishino T (2000) Responses of tracheobronchial receptors to inhaled furosemide in anesthetized rats. Am J Respir Crit Care Med 162(3 Pt 1):971–975PubMedGoogle Scholar
  304. Szallasi A (1994) The vanilloid (capsaicin) receptor: receptor types and species differences. Gen Pharmacol 25:223–243PubMedGoogle Scholar
  305. Szallasi A, Blumberg PM (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51:159–211PubMedGoogle Scholar
  306. Szarek JL, Gillespie MN, Altiere RJ, Diamond L (1986) Reflex activation of the nonadrenergic noncholinergic inhibitory nervous system in feline airways. Am Rev Respir Dis 133:1159–1162PubMedGoogle Scholar
  307. Szarek JL, Stewart NL, Spurlock B, Schneider C (1995) Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats. J Appl Physiol 78(5): 1679–1687PubMedGoogle Scholar
  308. Taguchi O, Kikuchi Y, Hida W, Iwase N, Satoh M, Chonan T, Takishima T (1991) Effects of bronchoconstriction and external resistive loading on the sensation of dyspnea. J Appl Physiol 71:2183–2190PubMedGoogle Scholar
  309. Taguchi O, Kikuchi Y, Hida W, Iwase N, Okabe S, Chonan T, Takishima T (1992) Prostaglandin E2 inhalation increases the sensation of dyspnea during exercise. Am Rev Respir Dis 145:1346–1349PubMedGoogle Scholar
  310. Takagi S, Umezaki T, Shin T (1995) Convergence of laryngeal afferents with different natures upon cat NTS neurons. Brain Res Bull 38:261–268PubMedGoogle Scholar
  311. Takahashi T, Belvisi MG, Barnes PJ (1994) Modulation of neurotransmission in guinea-pig airways by galanin and the effect of a new antagonist galantide. Neuropeptides 26(4):245–251PubMedGoogle Scholar
  312. Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ (2007) Antinociceptive pharmacology of N-(4-chlorobenzyl)-N′-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. J Pharmacol Exp Ther 321:791–798PubMedGoogle Scholar
  313. Tatar M, Sant'Ambrogio G, Sant'Ambrogio FB (1994) Laryngeal and tracheobronchial cough in anesthetized dogs. J Appl Physiol 76:2672–2679PubMedGoogle Scholar
  314. Tatar M, Pecova R, Karcolova D (1997) Sensitivity of the cough reflex in awake guinea pigs, rats and rabbits. Bratisl Lek Listy 98:539–543PubMedGoogle Scholar
  315. Tatar M, Webber SE, Widdicombe JG (1988) Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J Physiol 402:411–420PubMedGoogle Scholar
  316. Taylor-Clark TE, McAlexander MA, Nassenstein C, Sheardown SA, Wilson S, Thornton J, Carr MJ, Undem BJ (2008) Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol 586:3447–3459PubMedGoogle Scholar
  317. Tepper JS, Costa DL, Fitzgerald S, Doerfler DL, Bromberg PA (1993) Role of tachykinins in ozone-induced acute lung injury in guinea pigs. J Appl Physiol 75:1404–1411PubMedGoogle Scholar
  318. Thompson JE, Scypinski LA, Gordon T, Sheppard D (1987) Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Am Rev Respir Dis 136:43–49PubMedGoogle Scholar
  319. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531–543PubMedGoogle Scholar
  320. Trevisani M, Milan A, Gatti R, Zanasi A, Harrison S, Fontana G, Morice AH, Geppetti P (2004) Antitussive activity of iodo-resiniferatoxin in guinea pigs. Thorax 59:769–772PubMedGoogle Scholar
  321. Tucker RC, Kagaya M, Page CP, Spina D (2001) The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. Br J Pharmacol 132:1127–1135PubMedGoogle Scholar
  322. Umeno E, McDonald DM, Nadel JA (1990) Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation. J Clin Invest 85:1905–1908PubMedGoogle Scholar
  323. Undem BJ, Kollarik M (2002) Characterization of the vanilloid receptor 1 antagonist iodo-resiniferatoxin on the afferent and efferent function of vagal sensory C-fibers. J Pharmacol Exp Ther 303(2):716–722PubMedGoogle Scholar
  324. Undem BJ, Meeker SN, Chen J (1994) Inhibition of neurally mediated nonadrenergic, noncholinergic contractions of guinea pig bronchus by isozyme-selective phosphodiesterase inhibitors. J Pharmacol Exp Ther 271(2):811–817PubMedGoogle Scholar
  325. Undem BJ, Carr MJ, Kollarik M (2002) Physiology and plasticity of putative cough fibres in the Guinea pig. Pulm Pharmacol Ther 15:193–198PubMedGoogle Scholar
  326. Undem BJ, Oh EJ, Lancaster E, Weinreich D (2003) Effect of extracellular calcium on excitability of guinea pig airway vagal afferent nerves. J Neurophysiol 89:1196–1204PubMedGoogle Scholar
  327. Undem BJ, Chuaychoo B, Lee MG, Weinreich D, Myers AC, Kollarik M (2004) Subtypes of vagal afferent C-fibres in guinea-pig lungs. J Physiol 556:905–917PubMedGoogle Scholar
  328. van den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koeter GH, Kauffman HF, Postma DS (2001) Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. Am J Respir Crit Care Med 164:1127–1132PubMedGoogle Scholar
  329. Van Schoor J, Joos GF, Pauwels RA (2000) Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur Respir J 16:514–533PubMedGoogle Scholar
  330. Van Schoor J, Joos GF, Pauwels RA (2002) Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma. Eur Respir J 19:997–1002PubMedGoogle Scholar
  331. Vardhan A, Kachroo A, Sapru HN (1993) Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings. Brain Res 618:23–31PubMedGoogle Scholar
  332. Verleden GM, Belvisi MG, Rabe KF, Miura M, Barnes PJ (1993) Beta 2-adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro. J Appl Physiol 74:1195–1199PubMedGoogle Scholar
  333. Vesely KR, Hyde DM, Stovall MY, Harkema JR, Green JF, Schelegle ES (1999) Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. J Appl Physiol 86:951–962PubMedGoogle Scholar
  334. Vidruk EH, Hahn HL, Nadel JA, Sampson SR (1977) Mechanisms by which histamine stimulates rapidly adapting receptors in dog lungs. J Appl Physiol 43:397–402PubMedGoogle Scholar
  335. Warr D (2006) The neurokinin1 receptor antagonist aprepitant as an antiemetic for moderately emetogenic chemotherapy. Expert Opin Pharmacother 7:1653–1658PubMedGoogle Scholar
  336. Watanabe N, Horie S, Michael GJ, Spina D, Page CP, Priestley JV (2005) Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system. Pulm Pharmacol Ther 18:187–197PubMedGoogle Scholar
  337. Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV (2006) Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience 141:1533–1543PubMedGoogle Scholar
  338. Welch JM, Simon SA, Reinhart PH (2000) The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc Natl Acad Sci USA 97:13889–13894PubMedGoogle Scholar
  339. Widdicombe JG (1954a) Receptors in the trachea and bronchi of the cat. J Physiol 123:71–104PubMedGoogle Scholar
  340. Widdicombe JG (1954b) Respiratory reflexes from the trachea and bronchi of the cat. J Physiol 123:55–70PubMedGoogle Scholar
  341. Wilson CG, Zhang Z, Bonham AC (1996) Non-NMDA receptors transmit cardiopulmonary C fibre input in nucleus tractus solitarii in rats. J Physiol 496 (Pt 3):773–785PubMedGoogle Scholar
  342. Wine JJ (2007) Parasympathetic control of airway submucosal glands: central reflexes and the airway intrinsic nervous system. Auton Neurosci 133:35–54PubMedGoogle Scholar
  343. Winning AJ, Hamilton RD, Shea SA, Knott C, Guz A (1985) The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man. Clin Sci (Lond) 68(2):215–225Google Scholar
  344. Winning AJ, Hamilton RD, Shea SA, Guz A (1986) Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity. Clin Sci (Lond) 71(5):519–526Google Scholar
  345. Wu ZX, Satterfield BE, Dey RD (2003) Substance P released from intrinsic airway neurons contributes to ozone-enhanced airway hyperresponsiveness in ferret trachea. J Appl Physiol 95:742–750PubMedGoogle Scholar
  346. Xiang A, Uchida Y, Nomura A, Iijima H, Sakamoto T, Ishii Y, Morishima Y, Masuyama K, Zhang M, Hirano K, Sekizawa K (2002) Involvement of thromboxane A(2) in airway mucous cells in asthma-related cough. J Appl Physiol 92:763–770PubMedGoogle Scholar
  347. Yamamoto Y, Atoji Y, Suzuki Y (1995) Nerve endings in bronchi of the dog that react with antibodies against neurofilament protein. J Anat 187(1):59–65PubMedGoogle Scholar
  348. Yamamoto Y, Ootsuka T, Atoji Y, Suzuki Y (1998) Morphological and quantitative study of the intrinsic nerve plexuses of the canine trachea as revealed by immunohistochemical staining of protein gene product 9.5. Anat Rec 250:438–447PubMedGoogle Scholar
  349. Yamamoto Y, Sato Y, Taniguchi K (2007) Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea. J Anat 211:775–783PubMedGoogle Scholar
  350. Yoshihara S, Nadel JA, Figini M, Emanueli C, Pradelles P, Geppetti P (1998) Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea pigs: role of kinins. Am J Respir Crit Care Med 157:547–552PubMedGoogle Scholar
  351. Yu J (2005) Airway mechanosensors. Respir Physiol Neurobiol 148:217–243PubMedGoogle Scholar
  352. Yu J, Coleridge JC, Coleridge HM (1987) Influence of lung stiffness on rapidly adapting receptors in rabbits and cats. Respir Physiol 68:161–176PubMedGoogle Scholar
  353. Yu J, Schultz HD, Goodman J, Coleridge JC, Coleridge HM, Davis B (1989) Pulmonary rapidly adapting receptors reflexly increase airway secretion in dogs. J Appl Physiol 67:682–687PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Johns Hopkins Asthma and Allergy CenterBaltimoreUSA
  2. 2.The Sackler Institute of Pulmonary Pharmacology, Division of Pharmaceutical Science5th Floor Hodgkin Building, King’s College LondonLondonUK

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