The Aging Process in Men

Chapter

Abstract

What is aging and how can it prevented? In principle intrinsic (basically the genes) and extrinsic factors (basically UV exposure and smoking) can be distinguished. Only extrinsic aging is prone to prevention.

Keywords

Stratum Corneum Premature Ageing Dermal Papilla Aged Skin Topical Retinoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Allsopp, R. C., H. Vaziri, et al (1992). “Telomere length predicts replicative capacity of human fibroblasts.” Proc Natl Acad Sci USA 89(21):10114–10118.PubMedCrossRefGoogle Scholar
  2. Antell, D. E. and E. M. Taczanowski (1999). “How environment and lifestyle choices influence the aging process.” Ann Plast Surg 43(6):585–588.PubMedCrossRefGoogle Scholar
  3. Berneburg, M., S. Grether-Beck, et al (1999). “Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.” J Biol Chem 274(22):15345–15349.PubMedCrossRefGoogle Scholar
  4. Bosset, S., M. Bonnet-Duquennoy, et al (2003). “Decreased expression of keratinocyte beta1 integrins in chronically sun-exposed skin in vivo.” Br J Dermatol 148(4):770–778.PubMedCrossRefGoogle Scholar
  5. Branchet, M. C., S. Boisnic, et al (1990). “Skin thickness changes in normal aging skin.” Gerontology 36(1):28–35.PubMedCrossRefGoogle Scholar
  6. Braverman, I. M. and E. Fonferko (1982). “Studies in cutaneous aging: I. The elastic fiber network.” J Invest Dermatol 78(5):434–443.PubMedCrossRefGoogle Scholar
  7. Breathnach, A. S. and L. M. Wyllie (1964). “Electron microscopy of melanocytes and melanosomes in freckled human epidermis.” J Invest Dermatol 42:389–394.PubMedGoogle Scholar
  8. Capri, M., S. Salvioli, et al (2006). “The genetics of human longevity.” Ann N Y Acad Sci 1067:252–263.PubMedCrossRefGoogle Scholar
  9. Carruthers, A., J. Carruthers, et al (2008). “A validated grading scale for marionette lines.” Dermatol Surg 34 (Suppl 2):S167–S172.PubMedCrossRefGoogle Scholar
  10. Chen, V. L., R. Fleischmajer, et al. et al (1986). “Immunochemistry of elastotic material in sun-damaged skin.” J Invest Dermatol 87(3):334–337.PubMedCrossRefGoogle Scholar
  11. Chung, J. (2001). “Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color.” Arch Dermatol 137:132–135.Google Scholar
  12. Chung, J. H., K. Yano, et al (2002). “Differential effects of photoaging vs intrinsic aging on the vascularization of human skin.” Arch Dermatol 138(11):1437–1442.PubMedCrossRefGoogle Scholar
  13. Dzubow, L. (1991). The aging face. W. Coleman, W. Hanke, T. Alt and S. Asken(eds), Cosmetic Surgery of the Skin. Philadelphia, B.C. Decker pp 1–12.Google Scholar
  14. El-Domyati, M., S. Attia, et al (2002). “Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin.” Exp Dermatol 11(5):398–405.PubMedCrossRefGoogle Scholar
  15. Elsner, P., S. Beissert, et al (2005). “Sunprotection: possibilities and limitations.” J Dtsch Dermatol Ges 3(Suppl 2):S40–S44.PubMedGoogle Scholar
  16. Ernster, V. L., D. Grady, et al (1995). “Facial wrinkling in men and women, by smoking status.” Am J Public Health 85(1):78–82.PubMedCrossRefGoogle Scholar
  17. Fisher, G. J., Z. Q. Wang, et al (1997). “Pathophysiology of premature skin aging induced by ultraviolet light.” N Engl J Med 337(20):1419–1428.PubMedCrossRefGoogle Scholar
  18. Gilchrest, B. (1992). “The variable face of photoaging: influence of the skin type.” Cosmet Toiletries 107:41–42.Google Scholar
  19. Gilchrest, B. A. (1989). “Skin aging and photoaging: an overview.” J Am Acad Dermatol 21(3 Pt 2):610–613.PubMedCrossRefGoogle Scholar
  20. Gilchrest, B. A., F. B. Blog, et al (1979). “Effects of aging and chronic sun exposure on melanocytes in human skin.” J Invest Dermatol 73(2):141–143.PubMedCrossRefGoogle Scholar
  21. Gilchrest, B. A. and G. Rogers (1993). Photoaging. H. Lim and N. Soter (eds), Clinical Photomedicine. New York, Marcel Dekker pp 95–111.Google Scholar
  22. Grether-Beck, S., M. Wlaschek, et al (2005). “Photodamage and photoaging–prevention and treatment.” J Dtsch Dermatol Ges 3(Suppl 2):S19–S25.PubMedGoogle Scholar
  23. Gross, B., M. Landthaler, et al (2003). “Smoking – effects on the skin.” J Dtsch Dermatol Ges 1(10):801–809; quiz 810, 812.PubMedCrossRefGoogle Scholar
  24. Guinot, C., D. J. Malvy, et al (2002). “Relative contribution of intrinsic vs extrinsic factors to skin aging as determined by a validated skin age score.” Arch Dermatol 138(11):1454–1460.PubMedCrossRefGoogle Scholar
  25. Hanson, K. M. and J. D. Simon (1998). “Epidermal trans-urocanic acid and the UV-A-induced photoaging of the skin.” Proc Natl Acad Sci USA 95(18):10576–10578.PubMedCrossRefGoogle Scholar
  26. Harley, C. B., A. B. Futcher, et al (1990). “Telomeres shorten during ageing of human fibroblasts.” Nature 345(6274):458–460.PubMedCrossRefGoogle Scholar
  27. Harman, D. (2003). “The free radical theory of aging.” Antioxid Redox Signal 5(5):557–561.PubMedCrossRefGoogle Scholar
  28. Honeck, P., C. Weiss, et al (2003). “Reproducibility of a four-point clinical severity score for glabellar frown lines.” Br J Dermatol 149(2):306–310.PubMedCrossRefGoogle Scholar
  29. Kadunce, D. P., R. Burr, et al (1991). “Cigarette smoking: risk factor for premature facial wrinkling.” Ann Intern Med 114(10):840–844.PubMedGoogle Scholar
  30. Kligman, A. M. (1969). “Early destructive effect of sunlight on human skin.” JAMA 210(13):2377–2380.PubMedCrossRefGoogle Scholar
  31. Kligman, L. H. and G. F. Murphy (1996). “Ultraviolet B radiation increases hairless mouse mast cells in a dose-dependent manner and alters distribution of UV-induced mast cell growth factor.” Photochem Photobiol 63(1):123–127.PubMedCrossRefGoogle Scholar
  32. Koh, J. S., H. Kang, et al (2002). “Cigarette smoking associated with premature facial wrinkling: image analysis of facial skin replicas.” Int J Dermatol 41(1):21–27.PubMedCrossRefGoogle Scholar
  33. Kosmadaki, M. G. and B. A. Gilchrest (2004). “The role of telomeres in skin aging/photoaging.” Micron 35(3):155–159.PubMedCrossRefGoogle Scholar
  34. Lavker (1988). “Chronic heliodermatitis: a morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells.” J Invest Dermatol 90:325–330.PubMedCrossRefGoogle Scholar
  35. Lavker, R. (1995). Cutaneous photoaging: chronologic versus photoaging. B.A. Gilchrest (ed), Photodamage. Blackwell Science pp 123–125.Google Scholar
  36. Lee, H. C. and Y. H. Wei (2007). “Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.” Exp Biol Med (Maywood) 232(5):592–606.Google Scholar
  37. Leung, W. C. and I. Harvey (2002). “Is skin ageing in the elderly caused by sun exposure or smoking?” Br J Dermatol 147(6):1187–1191.PubMedCrossRefGoogle Scholar
  38. Lever, W. (1990). Histopathology of the Skin. Philadelphia, Lippincott.Google Scholar
  39. Leverkus, M. (2004). “Photoprotection: effects and side effects.” Gesundheitswesen 66(Suppl 1):S43–S46.PubMedGoogle Scholar
  40. Leyden, J. J. (1990). “Clinical features of ageing skin.” Br J Dermatol 122(Suppl 35):1–3.PubMedCrossRefGoogle Scholar
  41. Loeb, L. A., D. C. Wallace, et al (2005). “The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.” Proc Natl Acad Sci USA 102(52):18769–18770.PubMedCrossRefGoogle Scholar
  42. Lopez Hernandez, B. (1995). “Skin aging and smoking.” Rev Clin Esp 195:147–149.PubMedGoogle Scholar
  43. Ma, W., M. Wlaschek, et al (2001). “Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue.” Clin Exp Dermatol 26(7):592–599.PubMedCrossRefGoogle Scholar
  44. Miquel, J. (1998). “An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications.” Exp Gerontol 33(1–2):113–126.PubMedCrossRefGoogle Scholar
  45. Mitchell, R. E. (1967). “Chronic solar dermatosis: a light and electron microscopic study of the dermis.” J Invest Dermatol 48(3):203–220.PubMedGoogle Scholar
  46. Montagna, W., S. Kirchner, et al (1989). “Histology of sun-damaged human skin.” J Am Acad Dermatol 21(5 Pt 1):907–918.PubMedCrossRefGoogle Scholar
  47. Nagashima, H., K. Hanada, et al (1999). “Correlation of skin phototype with facial wrinkle formation.” Photodermatol Photoimmunol Photomed 15(1):2–6.PubMedCrossRefGoogle Scholar
  48. Oikarinen, A. (1990). “The aging of skin: chronoaging versus photoaging.” Photodermatol Photoimmunol Photomed 7(1):3–4.PubMedGoogle Scholar
  49. Purba, M. B., A. Kouris-Blazos, et al (2001). “Can skin wrinkling in a site that has received limited sun exposure be used as a marker of health status and biological age?” Age Ageing 30(3):227–234.PubMedCrossRefGoogle Scholar
  50. Rexbye, H., I. Petersen, et al (2006). “Influence of environmental factors on facial ageing.” Age Ageing 35(2):110–115.PubMedCrossRefGoogle Scholar
  51. Salvioli, S., F. Olivieri, et al (2006). “Genes, ageing and longevity in humans: problems, advantages and perspectives.” Free Radic Res 40(12):1303–1323.PubMedCrossRefGoogle Scholar
  52. Sams, W. M., Jr. and J. G. Smith, Jr. (1961). “The histochemistry of chronically sun-damaged skin. An investigation of mucopolysaccharides and basophilia in actinically damaged skin using alcian blue, mowry’s, and Hicks-Matthaei stains, methylation, and saponification.” J Invest Dermatol 37:447–453.PubMedCrossRefGoogle Scholar
  53. Schaefer, H., D. Moyal, et al (2000). “State of the art sunscreens for prevention of photodermatoses.” J Dermatol Sci 23(Suppl 1):S62–S74.PubMedCrossRefGoogle Scholar
  54. Scharffetter-Kochanek, K., P. Brenneisen, et al (2000). “Photoaging of the skin from phenotype to mechanisms.” Exp Gerontol 35(3):307–316.PubMedCrossRefGoogle Scholar
  55. Seite, S., A. Colige, et al (2000). “A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging.” Photodermatol Photoimmunol Photomed 16(4):147–155.PubMedCrossRefGoogle Scholar
  56. Sherertz, E. F. and S. P. Hess (1993). “Stated age.” N Engl J Med 329(4):281–282.PubMedCrossRefGoogle Scholar
  57. Smith, J. B. and N. A. Fenske (1996). “Cutaneous manifestations and consequences of smoking.” J Am Acad Dermatol 34(5 Pt 1):717–732; quiz 733–734.PubMedGoogle Scholar
  58. Smith, J. G., Jr., E. A. Davidson, et al. et al (1962). “Alterations in human dermal connective tissue with age and chronic sun damage.” J Invest Dermatol 39:347–350.PubMedCrossRefGoogle Scholar
  59. Sugimoto, M., R. Yamashita, et al (2006). “Telomere length of the skin in association with chronological aging and photoaging.” J Dermatol Sci 43(1):43–47.PubMedCrossRefGoogle Scholar
  60. Taylor, C. R., R. S. Stern, et al (1990). “Photoaging/photodamage and photoprotection.” J Am Acad Dermatol 22(1):1–15.PubMedCrossRefGoogle Scholar
  61. Trautinger, F., A. Trenz, et al (1989). “Influence of UV radiation on dermal collagen content in hairless mice.” Arch Dermatol Res 281:144.Google Scholar
  62. Uitto, J. (1986). “Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin.” Dermatol Clin 4(3):433–446.PubMedGoogle Scholar
  63. Uitto, J. and E. F. Bernstein (1998). “Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis.” J Investig Dermatol Symp Proc 3(1):41–44.PubMedCrossRefGoogle Scholar
  64. van der Rest, M. and R. Garrone (1991). “Collagen family of proteins.” FASEB J 5(13): 2814–2823.PubMedGoogle Scholar
  65. Varani, J., R. L. Warner, et al (2000). “Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin.” J Invest Dermatol 114(3):480–486.PubMedCrossRefGoogle Scholar
  66. Vijg, J. and N. van Orsouw (2002). “Searching for genetic determinants of human aging and longevity: opportunities and challenges.” Mech Ageing Dev 123(2–3):195–205.PubMedCrossRefGoogle Scholar
  67. Wei, Y. H. (1998). “Oxidative stress and mitochondrial DNA mutations in human aging.” Proc Soc Exp Biol Med 217(1):53–63.PubMedGoogle Scholar
  68. Wei, Y. H. and H. C. Lee (2002). “Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging.” Exp Biol Med (Maywood) 227(9):671–682.Google Scholar
  69. Werth, V. P., X. Shi, et al (1996). “Elastic fiber-associated proteins of skin in development and photoaging.” Photochem Photobiol 63(3):308–313.PubMedCrossRefGoogle Scholar
  70. Yaar, M. and B. A. Gilchrest (1998). “Aging versus photoaging: postulated mechanisms and effectors.” J Investig Dermatol Symp Proc 3(1):47–51.PubMedCrossRefGoogle Scholar
  71. Yaar, M. and B. A. Gilchrest (2001). “Skin aging: postulated mechanisms and consequent changes in structure and function.” Clin Geriatr Med 17(4):617–630, v.PubMedCrossRefGoogle Scholar
  72. Yin, L., A. Morita, et al (2001). “Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies.” Photodermatol Photoimmunol Photomed 17(4):178–183.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Division of Evidence Based Medicine (dEBM), Klinik für DermatologieCharité – Universitätsmedizin BerlinBerlinGermany
  2. 2.Resident in Dermatology Division of Evidence Based Medicine (dEBM)Klinik für Dermatologie, Charité – Universitätsmedizin BerlinBerlinGermany

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