Conceptual Biology Research Supporting Platform: Current Design and Future Directions
Conceptual biology utilizes a vast amount of published biomedical data to enhance and speed up biomedical research. Current computational study on conceptual biology focuses on hypothesis generation from biomedical literature. Most of the algorithms for hypothesis generation are dedicated to produce one type of hypothesis called pairwise relation by interacting with certain search engines such as PubMed. In order to fully realize the potential of conceptual biology, we designed and implemented a conceptual biology research support platform that consists of a set of interrelated information extraction, mining, reasoning, and visualizing technologies to automatically generate several types of biomedical hypotheses and to facilitate researchers in validating generated hypotheses. In this chapter, we provide detailed descriptions of the platform architecture, the algorithms for generating novel hypotheses, and the technologies for visualizing generated hypotheses. Furthermore, we propose a set of computational procedures and measures for evaluating generated hypotheses. The experimental analysis of the proposed hypothesis generation algorithms is also presented.
KeywordsObesity Magnesium Migraine Arginine Methotrexate
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- 4.Don RS (1990) Somatomedin C and arginine: implicit connection between mutually-isolated literatures. Perspective in Biology and Medicine 33(2):157–186.Google Scholar
- 5.Gambineri A, Patton L, Vaccina A, Cacciari M, Morselli-Labate AM, Cavazza C, Pagotto U, Pasquali R (2006) Treatment with utamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study. Journal of Clinical Endocrinology & Metabolism 91(10):3970–3980.CrossRefGoogle Scholar
- 6.Drugbank. http://redpoll.pharmacy.ualberta.ca/drugbankas of October, 2007.
- 7.ExPAsy Proteomics Server (ExPAsy). http://ca.ExPAsy.org/as of October, 2007.
- 8.Hongkun Z, Weiyi M, Zonghuan W, Vijay VR, Clement TY (2005) Fully automatic wrapper generation for search engines. Proceedings of the 14th International World Wide Web Conference (Chiba, Japan) 66–75.Google Scholar
- 9.Hu X, Zhang X, Li G, Yoo I, Zhou X, Wu D (to be published) Mining Hidden Connections among Biomedical Concepts from Disjoint Biomedical Literature Sets through Semantic-based Association Rule. International Journal of Intelligent Systems.Google Scholar
- 13.Ohtomo S, Izuhara Y, Takizawa S, Yamada N, Kakuta T, van Ypersele de Strihou C, Miyata T (2007) Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model. Kidney international.Google Scholar
- 15.The RCSB Protein Data Bank (PDB). http://www.rcsb.org/pdb/home/home.doas of October, 2007
- 16.PubMed. http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMedas of October, 2007.
- 17.Selego. http://www.selego.comas of Octorber, 2007.
- 18.Tanja B(2006) Conceptual biology, hypothesis discovery, and text mining: Swanson's legacy. Biomedical Digital Library 3(2).Google Scholar
- 19.Uni_ed Medical Language System (UMLS): http://umlsinfo.nlm.nih.gov/as of October, 2007.
- 20.Wanda P, Meliha Y(2003) LitLinker: capturing connections across the biomedical literature. Proceedings of the 2nd international conference on Knowledge capture (New York, USA) 105–112.Google Scholar
- 21.Weeber M, Klein H, Aronson AR, Mork JG, JongVan Den Berg L, Vos R(2000) Text-based discovery in biomedicine: the architecture of the DAD-system. Proceedings of the AMIA Annual FALL Symposium(Philadelphia, USA) 903–907.Google Scholar
- 22.Yiyu Y, A Framework for Web-based Research Support Systems. Proceedings of 27th Annual International Computer Software and Applications Conference (Dallas, USA) 601–606.Google Scholar
- 23.1999 The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care 22(4):623–634.Google Scholar