Computational Modelling Strategies for Gene Regulatory Network Reconstruction

  • Muhammad Shoaib Sehgal
  • Iqbal Gondal
  • Laurence Dooley

Gene Regulatory Network (GRN) modelling infers genetic interactions between different genes and other cellular components to elucidate the cellular functionality. This GRN modelling has overwhelming applications in biology starting from diagnosis through to drug target identification. Several GRN modelling methods have been proposed in the literature, and it is important to study the relative merits and demerits of each method. This chapter provides a comprehensive comparative study on GRN reconstruction algorithms. The methods discussed in this chapter are diverse and vary from simple similarity based methods to state of the art hybrid and probabilistic methods. In addition, the chapter also underpins the need of strategies which should be able to model the stochastic behavior of gene regulation in the presence of limited number of samples, noisy data, multi-collinearity for high number of genes.

Keywords

Gene Regulatory Networks Deterministic Modelling Stochastic Modelling Computational Intelligence Methods for GRN Modelling 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Muhammad Shoaib Sehgal
    • 1
  • Iqbal Gondal
    • 1
  • Laurence Dooley
    • 1
  1. 1.Monash UniversityAustralia

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