Computational Intelligence in Medical Informatics

Volume 85 of the series Studies in Computational Intelligence pp 1-16

Review of Computational Intelligence for Gene-Gene and Gene-Environment Interactions in Disease Mapping

  • Arpad KelemenAffiliated with
  • , Yulan LiangAffiliated withDepartment of Biostatistics University at Buffalo, The State University of New York
  • , Athanasios VasilakosAffiliated withDept. of Computer and Telecommunications Engineering, University of Western Macedonia

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Comprehensive evaluation of common genetic variations through association of SNP structure with common complex disease in the genome-wide scale is currently a hot area in human genome research. Computational science, which includes computational intelligence, has recently become the third method of scientific enquiry besides theory and experimentation. Interest grew fast in developing and applying computational intelligence techniques to disease mapping using SNP and haplotype data. This review provides a coverage of recently developed theories and applications in computational intelligence for gene-gene and gene-environment interactions in complex diseases in genetic association study.


Computational intelligence SNP Haplotype Complex common diseases Gene-gene interactions Gene-environment interactions