Simultaneous Segmentation, Kinetic Parameter Estimation, and Uncertainty Visualization of Dynamic PET Images

  • Ahmed Saad
  • Ben Smith
  • Ghassan Hamarneh
  • Torsten Möller
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4792)


We develop a segmentation technique for dynamic PET incorporating the physiological parameters for different regions via kinetic modeling. We demonstrate the usefulness of our technique on fifteen [11C]Raclopride simulated PET images. We show qualitatively and quantitatively that the physiologically based algorithm outperforms two classical segmentation techniques. Further, we derive a formula to compute and visualize the uncertainty encountered during the segmentation.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Ahmed Saad
    • 1
    • 2
  • Ben Smith
    • 1
    • 2
  • Ghassan Hamarneh
    • 1
  • Torsten Möller
    • 2
  1. 1.Medical Image Analysis Lab 
  2. 2.Graphics, Usability, and Visualization Lab, School of Computing Science, Simon Fraser UniversityCanada

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