Pharmacology of Neurotransmitter Transport into Secretory Vesicles

  • Farrukh A. Chaudhry
  • Jean-Luc Boulland
  • Monica Jenstad
  • May K. L. Bredahl
  • Robert H. Edwards
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 184)

Many neuropsychiatric disorders appear to involve a disturbance of chemical neurotransmission, and the mechanism of available therapeutic agents supports this impression. Postsynaptic receptors have received considerable attention as drug targets, but some of the most successful agents influence presynaptic processes, in particular neurotransmitter reuptake. The pharmacological potential of many other presynaptic elements, and in particular the machinery responsible for loading transmitter into vesicles, has received only limited attention. The similarity of vesicular transporters to bacterial drug resistance proteins and the increasing evidence for regulation of vesicle filling and recycling suggest that the pharmacological potential of vesicular transporters has been underestimated. In this review, we discuss the pharmacological effects of psychostimulants and therapeutic agents on transmitter release.


Synaptic Vesicle Secretory Vesicle Glutamate Uptake Evans Blue Vesicular Monoamine Transporter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Farrukh A. Chaudhry
    • 1
  • Jean-Luc Boulland
    • 2
  • Monica Jenstad
    • 3
  • May K. L. Bredahl
    • 4
  • Robert H. Edwards
    • 5
  1. 1.The Biotechnology Centre of Oslo, Centre for Molecular Biology and NeuroscienceUniversity of OsloBlindern, OsloNorway
  2. 2.The Biotechnology Centre of Oslo, Centre for Molecular Biology and NeuroscienceUniversity of OsloOsloNorway
  3. 3.The Biotechnology Centre of Oslo, Centre for Molecular Biology and NeuroscienceUniversity of OsloOsloNorway
  4. 4.The Biotechnology Centre of OsloUniversity of OsloOsloNorway
  5. 5.Departments of Neurology and PhysiologyUniversity of California, San Francisco School of MedicineCaliforniaUSA

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