Presynaptic Adenosine and P2Y Receptors

  • Jorge Gonçalves
  • Glória Queiroz
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 184)

Adenine-based purines, such as adenosine and ATP, are ubiquitous molecules that, in addition to their roles in metabolism, act as modulators of neurotransmitter release through activation of presynaptic P1 purinoceptors or adenosine receptors (activated by adenosine) and P2 receptors (activated by nucleotides). Of the latter, the P2Y receptors are G protein-coupled, whereas the P2X receptors are ligand-gated ion channels and not covered in this review.


Adenosine Receptor Neurotransmitter Release Noradrenaline Release Adenosine Receptor Agonist Endogenous Adenosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Jorge Gonçalves
    • 1
  • Glória Queiroz
    • 1
  1. 1.Department of PharmacologyUniversity of PortoPortoPortugal

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