Predicting Functional Protein-Protein Interactions Based on Computational Methods

  • Luwen Zhang
  • Wu Zhang
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4689)

Abstract

Protein-protein interactions play a crucial role in the cellular process. In recent years, yet new experimental techniques have been developed to discover the protein-protein interaction networks, the accuracy and coverage has still proven to be limited. Computational approaches come into being essential both to assist in the design and validation of experimental studies and for the prediction of interacted proteins. This paper presents a survey of the major computational methods for detecting protein-protein interactions, and expatiates on their key contribution by introducing the experimental methods, the typical computational methods and the improvement over them in turn.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Luwen Zhang
    • 1
  • Wu Zhang
    • 1
  1. 1.School of Computer Science and Technology, Shanghai University, Shanghai, 200072China

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