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The Important and Diverse Roles of Antibodies in the Host Response to Borrelia Infections

  • T. J. LaRocca
  • J. L. Benach
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 319)

Abstract

Antibodies are of critical importance in the host response to tick-borne Borrelia species that cause relapsing fever and Lyme disease. Recent studies on the role of various B cell subsets in the host response to Borrelia, complement-independent, bactericidal antibodies, and diagnostics led to this review that focuses on the array of functions that antibodies to Borrelia can perform.

Keywords

Lyme Disease Borrelia Burgdorferi Lyme Borreliosis Lyme Arthritis Outer Surface Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Arp

Arthritis-related protein

C4BP

C4b-binding protein

CNS

Central nervous system

CRASP

Complement regulator acquiring surface protein

CSF

Cerebrospinal fluid

Dbp

Decorin-binding protein

DHS

Downstream homology sequence

d.p.i.

Days postinoculation

ELISA

Enzyme-linked immunosorbent assay

Fab

Fragment antigen binding

Fc

Fragment crystallizable

FcRn

Neonatal Fc receptor

Fhb

Factor H-binding protein

FO B cells

Follicular B cells

GlpQ

Glycerophosphodiester phosphodiesterase

HUVEC

Human umbilical vein endothelial cells

IFA

Indirect immunofluorescence assay

LPS

Lipopolysaccharide

MAb

Monoclonal antibody

MAC

Membrane attack complex

MZ B cells

Marginal zone B cells

OM

Outer membrane

Osp

Outer surface protein

scFv

Single-chain variable fragment

SCID

Severe combined immunodeficiency

TRLA

Treatment-resistant Lyme arthritis

UHS

Upstream homology sequence

Vlp

Variable large protein

VlsE

Vmp-like sequence, expressed

Vmp

Variable major protein

Vsp

Variable small protein

w.p.i.

Weeks postinoculation

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • T. J. LaRocca
  • J. L. Benach
    • 1
  1. 1.Center for Infectious Diseases5120 Centers for Molecular MedicineStony BrookUSA

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