Pattern Recognition by B Cells: The Role of Antigen Repetitiveness Versus Toll-Like Receptors

  • H. J. Hinton
  • A. Jegerlehner
  • M. F. Bachmann
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 319)


Viruses induce excellent antibody responses due to several intrinsic features. Their repetitive, organised structure is optimal for the activation of the B cell receptor (BCR), leading to an increased humoral response and a decreased dependence on T cell help. Viruses also trigger Toll-like receptors (TLRs), which in addition to increasing overall Ig levels, drive the switch to the IgG2a isotype. This isotype is more efficient in viral and bacterial clearance and will activate complement, which in turn lowers the threshold of BCR activation. Exploiting these characteristics in vaccine design may help us to create vaccines which are as safe as a recombinant vaccine yet still as effective as a virus in inducing B cell responses.


Vesicular Stomatitis Virus Epitope Density Antigen Organisation Antigen Repetitiveness High Epitope Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Antigen-presenting cell


B cell receptor










Red blood cell


Ribonucleic acid


Signal transducers and activators of transcription


T cell-dependent


T cell-independent


Toll-like receptor


Virus-like particle


Vesicular stomatitis virus


Glycoprotein of vesicular stomatitis virus


X-linked immunodeficiency


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • H. J. Hinton
  • A. Jegerlehner
  • M. F. Bachmann
    • 1
  1. 1.Cytos Biotechnology AGZürich-SchlierenSwitzerland

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