FPF-SB: A Scalable Algorithm for Microarray Gene Expression Data Clustering
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- Geraci F., Leoncini M., Montangero M., Pellegrini M., Renda M.E. (2007) FPF-SB: A Scalable Algorithm for Microarray Gene Expression Data Clustering. In: Duffy V.G. (eds) Digital Human Modeling. ICDHM 2007. Lecture Notes in Computer Science, vol 4561. Springer, Berlin, Heidelberg
Efficient and effective analysis of large datasets from microarray gene expression data is one of the keys to time-critical personalized medicine. The issue we address here is the scalability of the data processing software for clustering gene expression data into groups with homogeneous expression profile. In this paper we propose FPF-SB, a novel clustering algorithm based on a combination of the Furthest-Point-First (FPF) heuristic for solving the k-center problem and a stability-based method for determining the number of clusters k. Our algorithm improves the state of the art: it is scalable to large datasets without sacrificing output quality.
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