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Supervised Neural Gas for Classification of Functional Data and Its Application to the Analysis of Clinical Proteom Spectra

  • Frank-Michael Schleif
  • Thomas Villmann
  • Barbara Hammer
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4507)

Abstract

The analysis of functional data, is a common task in bioinformatics. Spectral data as obtained from mass spectrometric measurements in clinical proteomics are such functional data leading to new challenges for an appropriate analysis. Here we focus on the determination of classification models for such data. In general the available approaches for this task initially transform the spectra into a vector space followed by training a classifier. Hereby the functional nature of the data is typically lost, which may lead to suboptimal classifier models. Taking this into account a wavelet encoding is applied onto the spectral data leading to a compact functional representation. Further the Supervised Neural Gas classifier is extended by a functional metric. This allows the classifier to utilize the functional nature of the data in the modeling process. The presented method is applied to clinical proteom data showing good results.

Keywords

supervised neural gas functional data analysis clinical proteomics wavelet analysis spectra preprocessing 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Frank-Michael Schleif
    • 1
  • Thomas Villmann
    • 1
  • Barbara Hammer
    • 2
  1. 1.University Leipzig, Dept. of Medicine, 04107 LeipzigGermany
  2. 2.TU-Clausthal, Dept. of Math. & C.S., 38678 Clausthal-ZellerfeldGermany

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