Relating Discontinuous Cardiac Electrical Activity to Mesoscale Tissue Structures: Detailed Image Based Modeling

  • Mark L. Trew
  • Bruce H. Smaill
  • Andrew J. Pullan
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4466)


We relate aspects of discontinuous cardiac activation to the mesoscale myocardial structural feature of interlaminae clefts or cleavage planes. Specialized numerical and computational procedures have been developed for modeling cardiac activation which accounts for detailed myocardial geometric structures derived from specific tissue samples. This modeling allows both study and analysis of the effects of cleavage planes and other structural barriers to myocardial current flow. The results show that mesoscale discontinuities significantly affect the formation of virtual electrodes, and can result in discontinuous activation with midwall pacing.


Cardiac Tissue Cleavage Plane Virtual Cathode Line Discontinuity Virtual Source 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Mark L. Trew
    • 1
  • Bruce H. Smaill
    • 1
    • 2
  • Andrew J. Pullan
    • 1
    • 3
  1. 1.Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland 1142New Zealand
  2. 2.Department of Physiology 
  3. 3.Department of Engineering Science 

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