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Can We Trust the Transgenic Mouse? Insights from Computer Simulations

  • Joseph Tranquillo
  • Adhira Sunkara
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4466)

Abstract

Over the past several decades, the mouse has gained prominence in the cardiac electrophysiology literature as the animal model of choice. Using computer models of the mouse and human ECG, this paper is a step toward understanding when the mouse succeeds and fails to mimic functional changes resulting from disease states and drug interactions.

Keywords

Mouse Heart Brugada Syndrome Physiol Heart Circ Monophasic Action Potential Transient Outward Current 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Joseph Tranquillo
    • 1
  • Adhira Sunkara
    • 1
  1. 1.Bucknell University, Lewisburg PA 17837USA

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