A Model for Simulation of Infant Cardiovascular Response to Orthostatic Stress

  • Yutaka Nobuaki
  • Akira Amano
  • Takao Shimayoshi
  • Jianyin Lu
  • Eun B. Shim
  • Tetsuya Matsuda
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4466)


We developed an infant circulation model which incorporates an accurate myocardial cell model including a beta adrenergic system. The beta adrenergic system is essential for the response reproduction of the baroreflex control system. The proposed model was constructed by modifying the parameters of a human adult circulation model with the aid of a guinea pig myocardial cell model, whose baseline heart rate is close to that of an infant. The presented model is in good agreement with results obtained in physiological experiments.


Physiological Experiment Baseline Heart Rate Orthostatic Stress Heart Contractility Pressure Pulse Width 
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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Yutaka Nobuaki
    • 1
  • Akira Amano
    • 1
  • Takao Shimayoshi
    • 2
  • Jianyin Lu
    • 3
  • Eun B. Shim
    • 4
  • Tetsuya Matsuda
    • 1
  1. 1.Graduate School of Informatics, Kyoto University, KyotoJapan
  2. 2.ASTEM Research Institute of Kyoto, KyotoJapan
  3. 3.Cell/Biodynamics Simulation Project, Kyoto University, KyotoJapan
  4. 4.Division of Mechanical & Biomedical Engineering, Kangwon National UniversityKorea

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