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Computer Simulation of Altered Sodium Channel Gating in Rabbit and HumanVentricular Myocytes

  • Eleonora Grandi
  • Jose L. Puglisi
  • Stefano Severi
  • Donald M. Bers
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4466)

Abstract

Mathematical models were used to explore sodium (Na) current alterations. Markovian representations were chosen to describe the Na current behavior under pathological conditions, such as genetic defects (Long QT and Brugada syndromes) or acquired diseases (heart failure). These Na current formulations were subsequently introduced in an integrated model of the ventricular myocyte to investigate their effects on the ventricular action potential. This “in silico” approach is a powerful tool, providing new insights into arrhythmia susceptibility due to inherited and/or acquired Na channelopathies.

Keywords

Na channelopathies action potential arrhythmias 

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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Eleonora Grandi
    • 1
  • Jose L. Puglisi
    • 2
  • Stefano Severi
    • 1
  • Donald M. Bers
    • 2
  1. 1.Department of Electronics Computer Science and Systems, University of Bologna, Viale Risorgimento 2, 40136 BolognaItaly
  2. 2.Department of Physiology, Loyola University Chicago, 2160 South First Ave, 60153 Maywood, ILUSA

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