Upper Gastrointestinal Surgery: Current Trends and Recent Innovations

  • Danny Yakoub
  • Oliver Priest
  • Akram R. George
  • George B. Hanna

Abstract

Upper gastrointestinal surgery has witnessed an enormous leap in the last decade, largely related to introduction of new technologies; with the advent of NOTES and the advancement of robotic surgery and various endoscopic techniques, many of the now standard laparoscopic procedures are now being attempted through these approaches. It seems as this is a turnover of a new generation of surgical techniques which may once more change the face of surgical practice and values, just as laparoscopy did in the last two decades.

Another focus of interest is Barrett's esophagus, which has been one of the most studied upper gastrointestinal diseases in recent research studies owing to its identified risk of cancer development; making it one of few possible targets of cancer prevention.

Recently, the massive increase in rate of performance of bariatric surgeries has put these techniques in the focus of comprehensive research in terms of technical perfection as well as metabolic and physiological consequences.

As for other benign and malignant esophageal and gastric conditions, various studies have addressed both the surgical technical, and more importantly, the biological question of etiology, diagnosis and follow up. In spite of the achievements in the field, it is still open for vast future progress whether on the basic science frontier or on the clinical training and practice grounds.

Upper Gastrointestinal surgery has been an area of prolific development in recent decades. The introduction of obesity and metabolic operations has seen a dramatic expansion in view of the worldwide pandemic of obesity. Novel treatment therapies include the introduction of Natural Orifice Transluminal Endoscopic Surgery (NOTES), Endoluminal therapy, Endoscopic Mucosal Resection (EMR) and Photodynamic Therapy. There has been increased clarification of the mechanisms of Gastro-Esophageal Reflux Disease, Achalasia, Barrett's Esophagus and Esophageal Cancer. This includes disease progression and the use of tumour markers, molecular profiling, detection of micrometastases and diagnostic laparoscopic/thoracoscopic techniques. Other developments include an increased appreciation of surgical skills training and volume-outcome relationships.

Keywords

Gastric Cancer Positron Emission Tomography Esophageal Cancer Lower Esophageal Sphincter Laparoscopic Adjustable Gastric Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ballantyne GH (2007) Telerobotic gastrointestinal surgery: phase 2 – safety and efficacy. Surg Endosc 21:1054–1062PubMedGoogle Scholar
  2. 2.
    Ruurda JP, Broeders IA, Simmermacher RP et al (2002) Feasibility of robot-assisted laparoscopic surgery: an evaluation of 35 robot-assisted laparoscopic cholecystectomies. Surg Laparosc Endosc Percutan Tech 12:41–45PubMedGoogle Scholar
  3. 3.
    Berguer R, Smith W (2006) An ergonomic comparison of robotic and laparoscopic technique: the influence of surgeon experience and task complexity. J Surg Res 134:87–92PubMedGoogle Scholar
  4. 4.
    Bodner JC, Zitt M, Ott H et al (2005) Robotic-assisted tho-racoscopic surgery (RATS) for benign and malignant esoph-ageal tumors. Ann Thorac Surg 80:1202–1206PubMedGoogle Scholar
  5. 5.
    Kalloo AN, Singh VK, Jagannath SB et al (2004) Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity. Gastrointest Endosc 60:114–117PubMedGoogle Scholar
  6. 6.
    Pai RD, Fong DG, Bundga ME et al (2006) Transcolonic endoscopic cholecystectomy: a NOTES survival study in a porcine model (with video). Gastrointest Endosc 64:428–434PubMedGoogle Scholar
  7. 7.
    Rattner D, Kalloo A (2006) ASGE/SAGES Working Group on Natural Orifice Translumenal Endoscopic Surgery. Surg Endosc 20:329–333PubMedGoogle Scholar
  8. 8.
    Palanivelu C, Rajan PS, Rangarajan M et al (2008) Trans vaginal endoscopic appendectomy in humans: a unique approach to NOTES-world's first report. Surg Endosc 22:1343–1347PubMedGoogle Scholar
  9. 9.
    Bernhardt J, Gerber B, Schober HC et al (2008) NOTES – case report of a unidirectional flexible appendectomy. Int J Colorectal Dis 23:547–550PubMedGoogle Scholar
  10. 10.
    Rattner DW (2008) NOTES: Where have we been and where are we going? Surg Endosc 22:1143–1145PubMedGoogle Scholar
  11. 11.
    Triadafilopoulos G (2004) Changes in GERD symptom scores correlate with improvement in esophageal acid exposure after the Stretta procedure. Surg Endosc 18:1038–1044PubMedGoogle Scholar
  12. 12.
    Triadafilopoulos G (2007) Endotherapy and surgery for GERD. J Clin Gastroenterol 41(Suppl 2):S87–S96PubMedGoogle Scholar
  13. 13.
    Cicala M, Gabbrielli A, Emerenziani S et al (2005) Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux. Gut 54:183–186PubMedGoogle Scholar
  14. 14.
    Fockens P, Bruno MJ, Gabbrielli A et al (2004) Endoscopic augmentation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease: multicenter study of the Gatekeeper Reflux Repair System. Endoscopy 36:682–689PubMedGoogle Scholar
  15. 15.
    Pleskow D, Rothstein R, Lo S et al (2005) Endoscopic full-thickness plication for the treatment of GERD: 12-month follow-up for the North American open-label trial. Gastrointest Endosc 61:643–649PubMedGoogle Scholar
  16. 16.
    Pleskow D, Rothstein R, Kozarek R et al (2007) Endoscopic full-thickness plication for the treatment of GERD: long-term multicenter results. Surg Endosc 21:439–444PubMedGoogle Scholar
  17. 17.
    Pleskow D, Rothstein R, Kozarek R et al (2008) Endoscopic full-thickness plication for the treatment of GERD: five-year long-term multicenter results. Surg Endosc 22:326–332PubMedGoogle Scholar
  18. 18.
    Rothstein RI (2008) Endoscopic therapy of gastroesopha-geal reflux disease: outcomes of the randomized-controlled trials done to date. J Clin Gastroenterol 42:594–602PubMedGoogle Scholar
  19. 19.
    Conio M, Cameron AJ, Chak A et al (2005) Endoscopic treatment of high-grade dysplasia and early cancer in Barrett's oesophagus. Lancet Oncol 6:311–321PubMedGoogle Scholar
  20. 20.
    Conio M, Repici A, Cestari R et al (2005) Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: an Italian experience. World J Gastroenterol 11:6650–6655PubMedGoogle Scholar
  21. 21.
    Gross SA, Wolfsen HC (2008) The use of photodynamic therapy for diseases of the esophagus. J Environ Pathol Toxicol Oncol 27:5–21PubMedGoogle Scholar
  22. 22.
    Tokar JL, Haluszka O, Weinberg DS (2007) Endoscopic therapy of dysplasia and early-stage cancers of the esophagus. Semin Radiat Oncol 17:10–21PubMedGoogle Scholar
  23. 23.
    Wolfsen HC (2005) Present status of photodynamic therapy for high-grade dysplasia in Barrett's esophagus. J Clin Gastroenterol 39:189–202PubMedGoogle Scholar
  24. 24.
    Sproston P, Primatesta P (2003) Health survey for England 2002. The health of children and young people. The Stationery Office, LondonGoogle Scholar
  25. 25.
    Kopelman P, Jebb SA, Butland B. (2007) Executive Summary: Foresight ‘Tackling Obesities: Future Choices’ project. Obes Rev. Mar;8 Suppl 1:vi–ixPubMedGoogle Scholar
  26. 26.
    Field AE, Coakley EH, Must A et al (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161:1581–1586PubMedGoogle Scholar
  27. 27.
    Price GM, Uauy R, Breeze E et al (2006) Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. Am J Clin Nutr 84:449–460PubMedGoogle Scholar
  28. 28.
    Baumer JH. (2007) Obesity and overweight: its prevention, identification, assessment and management. Arch Dis Child Educ Pract Ed. Jun;92(3):ep92–6PubMedGoogle Scholar
  29. 29.
    Kohn GP, Galanko JA, Overby DW, Farrell TM. (2009) Recent Trends in bariatric surgery case volume in the United States. Surgery Aug:146(2):375–80PubMedGoogle Scholar
  30. 30.
    Schneider BE, Mun EC (2005) Surgical management of morbid obesity. Diabetes Care 28:475–480PubMedGoogle Scholar
  31. 31.
    Morino M, Toppino M, Bonnet G et al (2003) Laparoscopic adjustable silicone gastric banding versus vertical banded gastroplasty in morbidly obese patients: a prospective randomized controlled clinical trial. Ann Surg 238:835–841; discussion 841–842PubMedGoogle Scholar
  32. 32.
    Sugerman HJ, Kral JG (2005) Evidence-based medicine reports on obesity surgery: a critique. Int J Obes (Lond) 29:735–745Google Scholar
  33. 33.
    Alper D, Ramadan E, Vishne T et al (2000) Silastic ring vertical gastroplasty- long-term results and complications. Obes Surg 10:250–254PubMedGoogle Scholar
  34. 34.
    Suter M, Jayet C, Jayet A (2000) Vertical banded gastro-plasty: long-term results comparing three different techniques. Obes Surg 10:41–46; discussion 47PubMedGoogle Scholar
  35. 35.
    Belachew M, Legrand MJ, Defechereux TH et al (1994) Laparoscopic adjustable silicone gastric banding in the treatment of morbid obesity. A preliminary report. Surg Endosc 8:1354–1356Google Scholar
  36. 36.
    DeMaria EJ, Jamal MK (2005) Laparoscopic adjustable gastric banding: evolving clinical experience. Surg Clin North Am 85:773–787; viiPubMedGoogle Scholar
  37. 37.
    Angrisani L, Furbetta F, Doldi SB et al (2003) Lap band adjustable gastric banding system: the Italian experience with 1863 patients operated on 6 years. Surg Endosc 17:409–412PubMedGoogle Scholar
  38. 38.
    DeMaria EJ, Schauer P, Patterson E et al (2005) The optimal surgical management of the super-obese patient: the debate. Presented at the annual meeting of the Society of American Gastrointestinal and Endoscopic Surgeons, Hollywood, Florida, USA, April 13–16, 2005. Surg Innov 12:107–121PubMedGoogle Scholar
  39. 39.
    Weiner R, Blanco-Engert R, Weiner S et al (2003) Outcome after laparoscopic adjustable gastric banding – 8 years experience. Obes Surg 13:427–434PubMedGoogle Scholar
  40. 40.
    Dolan K, Hatzifotis M, Newbury L et al (2004) A comparison of laparoscopic adjustable gastric banding and biliopan-creatic diversion in superobesity. Obes Surg 14:165–169PubMedGoogle Scholar
  41. 41.
    Mognol P, Chosidow D, Marmuse JP (2005) Laparoscopic gastric bypass versus laparoscopic adjustable gastric banding in the super-obese: a comparative study of 290 patients. Obes Surg 15:76–81PubMedGoogle Scholar
  42. 42.
    Chevallier JM, Zinzindohoue F, Douard R et al (2004) Complications after laparoscopic adjustable gastric banding for morbid obesity: experience with 1,000 patients over 7 years. Obes Surg 14:407–414PubMedGoogle Scholar
  43. 43.
    Fielding GA, Ren CJ (2005) Laparoscopic adjustable gastric band. Surg Clin North Am 85:129–140; xPubMedGoogle Scholar
  44. 44.
    Dargent J (2005) Esophageal dilatation after laparoscopic adjustable gastric banding: definition and strategy. Obes Surg 15:843–848PubMedGoogle Scholar
  45. 45.
    Shen R, Dugay G, Rajaram K et al (2004) Impact of patient follow-up on weight loss after bariatric surgery. Obes Surg 14:514–519PubMedGoogle Scholar
  46. 46.
    Moon Han S, Kim WW, Oh JH (2005) Results of laparo-scopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patients. Obes Surg 15:1469–1475PubMedGoogle Scholar
  47. 47.
    Silecchia G, Boru C, Pecchia A et al (2006) Effectiveness of laparoscopic sleeve gastrectomy (first stage of biliopancre-atic diversion with duodenal switch) on co-morbidities in super-obese high-risk patients. Obes Surg 16:1138–1144PubMedGoogle Scholar
  48. 48.
    Frezza EE (2007) Laparoscopic vertical sleeve gastrectomy for morbid obesity. The future procedure of choice? Surg Today 37:275–281PubMedGoogle Scholar
  49. 49.
    Deviere J, Ojeda Valdes G, Cuevas Herrera L et al (2008) Safety, feasibility and weight loss after transoral gastroplasty: first human multicenter study. Surg Endosc 22:589–598PubMedGoogle Scholar
  50. 50.
    Kantsevoy SV, Hu B, Jagannath SB et al (2007) Technical feasibility of endoscopic gastric reduction: a pilot study in a porcine model. Gastrointest Endosc 65:510–513PubMedGoogle Scholar
  51. 51.
    Genco A, Bruni T, Doldi SB et al (2005) BioEnterics intra-gastric balloon: the Italian experience with 2,515 patients. Obes Surg 15:1161–1164PubMedGoogle Scholar
  52. 52.
    Genco A, Cipriano M, Bacci V et al (2006) BioEnterics intragastric balloon (BIB): a short-term, double-blind, randomised, controlled, crossover study on weight reduction in morbidly obese patients. Int J Obes (Lond) 30:129–133Google Scholar
  53. 53.
    Melissas J, Mouzas J, Filis D et al (2006) The intragastric balloon – smoothing the path to bariatric surgery. Obes Surg 16:897–902PubMedGoogle Scholar
  54. 54.
    Spyropoulos C, Katsakoulis E, Mead N et al (2007) Intragastric balloon for high-risk super-obese patients: a prospective analysis of efficacy. Surg Obes Relat Dis 3:78–83PubMedGoogle Scholar
  55. 55.
    Scopinaro N, Marinari G, Camerini G et al (2005) Biliopancreatic diversion for obesity: state of the art. Surg Obes Relat Dis 1:317–328PubMedGoogle Scholar
  56. 56.
    Buchwald H, Avidor Y, Braunwald E et al (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724–1737PubMedGoogle Scholar
  57. 57.
    Scopinaro N (2006) Biliopancreatic diversion: mechanisms of action and long-term results. Obes Surg 16:683–689PubMedGoogle Scholar
  58. 58.
    Scopinaro N, Papadia F, Marinari G et al (2007) Long-term control of type 2 diabetes mellitus and the other major components of the metabolic syndrome after biliopancreatic diversion in patients with BMI <35 kg/m2. Obes Surg 17:185–192PubMedGoogle Scholar
  59. 59.
    Tataranni PA, Mingrone G, Raguso CA et al (1996) Twenty-four-hour energy and nutrient balance in weight stable postobese patients after biliopancreatic diversion. Nutrition 12:239–244PubMedGoogle Scholar
  60. 60.
    Hess DS, Hess DW (1998) Biliopancreatic diversion with a duodenal switch. Obes Surg 8:267–282PubMedGoogle Scholar
  61. 61.
    Marceau P, Hould FS, Simard S et al (1998) Biliopancreatic diversion with duodenal switch. World J Surg 22:947–954PubMedGoogle Scholar
  62. 62.
    Feng JJ, Gagner M (2002) Laparoscopic biliopancreatic diversion with duodenal switch. Semin Laparosc Surg 9:125–129PubMedGoogle Scholar
  63. 63.
    Hess DS, Hess DW, Oakley RS (2005) The biliopancreatic diversion with the duodenal switch: results beyond 10 years. Obes Surg 15:408–416PubMedGoogle Scholar
  64. 64.
    Buchwald H (2005) Consensus conference statement bariat-ric surgery for morbid obesity: health implications for patients, health professionals, and third-party payers. Surg Obes Relat Dis 1:371–381PubMedGoogle Scholar
  65. 65.
    Scopinaro N, Marinari GM, Camerini G (2002) Laparoscopic standard biliopancreatic diversion: technique and preliminary results. Obes Surg 12:362–365PubMedGoogle Scholar
  66. 66.
    Scopinaro N, Gianetta E, Adami GF et al (1996) Biliopancreatic diversion for obesity at eighteen years. Surgery 119:261–268PubMedGoogle Scholar
  67. 67.
    Scopinaro N, Adami GF, Marinari GM et al (1998) Biliopancreatic diversion. World J Surg 22:936–946PubMedGoogle Scholar
  68. 68.
    Anthone GJ (2005) The duodenal switch operation for morbid obesity. Surg Clin North Am 85:819–833; viiiPubMedGoogle Scholar
  69. 69.
    Slater GH, Fielding GA (2004) Combining laparoscopic adjustable gastric banding and biliopancreatic diversion after failed bariatric surgery. Obes Surg 14:677–682PubMedGoogle Scholar
  70. 70.
    Santry HP, Gillen DL, Lauderdale DS (2005) Trends in bar-iatric surgical procedures. JAMA 294:1909–1917PubMedGoogle Scholar
  71. 71.
    DeMaria EJ (2004) Is gastric bypass superior for the surgical treatment of obesity compared with malabsorptive procedures? J Gastrointest Surg 8:401–403PubMedGoogle Scholar
  72. 72.
    Marema RT, Perez M, Buffington CK (2005) Comparison of the benefits and complications between laparoscopic and open Roux-en-Y gastric bypass surgeries. Surg Endosc 19:525–530PubMedGoogle Scholar
  73. 73.
    Podnos YD, Jimenez JC, Wilson SE et al (2003) Complications after laparoscopic gastric bypass: a review of 3464 cases. Arch Surg 138:957–961PubMedGoogle Scholar
  74. 74.
    Olbers T, Fagevik-Olsen M, Maleckas A et al (2005) Randomized clinical trial of laparoscopic Roux-en-Y gastric bypass versus laparoscopic vertical banded gastroplasty for obesity. Br J Surg 92:557–562PubMedGoogle Scholar
  75. 75.
    Raftopoulos I, Ercole J, Udekwu AO et al (2005) Outcomes of Roux-en-Y gastric bypass stratified by a body mass index of 70 kg/m2: a comparative analysis of 825 procedures. J Gastrointest Surg 9:44–52; discussion 52–53PubMedGoogle Scholar
  76. 76.
    Maggard MA, Shugarman LR, Suttorp M et al (2005) Meta-analysis: surgical treatment of obesity. Ann Intern Med 142:547–559PubMedGoogle Scholar
  77. 77.
    Stein HJ, Feith M (2005) Surgical strategies for early esophageal adenocarcinoma. Best Pract Res Clin Gastroenterol 19:927–940PubMedGoogle Scholar
  78. 78.
    Peyre CG, Hagen JA, DeMeester SR et al (2008) The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. Ann Surg 248:549–556PubMedGoogle Scholar
  79. 79.
    Kent MS, Schuchert M, Fernando H et al (2006) Minimally invasive esophagectomy: state of the art. Dis Esophagus 19:137–145PubMedGoogle Scholar
  80. 80.
    Pennathur A, Luketich JD (2008) Minimally invasive surgical treatment of esophageal carcinoma. Gastrointest Cancer Res 2:295PubMedGoogle Scholar
  81. 81.
    Luketich JD, Fernando HC, Christie NA et al (2001) Outcomes after minimally invasive esophagomyotomy. Ann Thorac Surg 72:1909–1912; discussion 1912–1903PubMedGoogle Scholar
  82. 82.
    Spechler SJ, Lee E, Ahnen D et al (2001) Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA 285:2331–2338PubMedGoogle Scholar
  83. 83.
    Garcia-Gallont R (2008) Laparoscopic fundoplication for GERD: are we there yet? Dig Dis 26:304–308PubMedGoogle Scholar
  84. 84.
    Gatenby PA, Ramus JR, Caygill CP et al (2009) Treatment modality and risk of development of dysplasia and adenocarci-noma in columnar-lined esophagus. Dis Esophagus 22:133–142PubMedGoogle Scholar
  85. 85.
    Smith CD (2008) Antireflux surgery. Surg Clin North Am 88:943–958; vPubMedGoogle Scholar
  86. 86.
    Fibbe C, Layer P, Keller J et al (2001) Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology 121:5–14PubMedGoogle Scholar
  87. 87.
    Laws HL, Clements RH, Swillie CM (1997) A randomized, prospective comparison of the Nissen fundoplication versus the Toupet fundoplication for gastroesophageal reflux disease. Ann Surg 225:647–653; discussion 654PubMedGoogle Scholar
  88. 88.
    Varin O, Velstra B, De Sutter S et al (2009) Total vs partial fundoplication in the treatment of gastroesophageal reflux disease: a meta-analysis. Arch Surg 144:273–278PubMedGoogle Scholar
  89. 89.
    Oelschlager BK, Chang L, Pellegrini CA (2003) Improved outcome after extended gastric myotomy for achalasia. Arch Surg 138:490–495; discussion 495–497PubMedGoogle Scholar
  90. 90.
    Neuner G, Patel A, Suntharalingam M (2009) Chemo radiotherapy for esophageal cancer. Gastrointest Cancer Res 3:57–65PubMedGoogle Scholar
  91. 91.
    Yakoub D, Fahmy R, Athanasiou T et al (2008) Evidence-based choice of esophageal stent for the palliative management of malignant dysphagia. World J Surg 32:1996–2009PubMedGoogle Scholar
  92. 92.
    Ferry DR, Anderson M, Beddard K et al (2007) A phase II study of gefitinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical response. Clin Cancer Res 13:5869–5875PubMedGoogle Scholar
  93. 93.
    Weichselbaum RR, Kufe D (2009) Translation of the radio-and chemo-inducible TNFerade vector to the treatment of human cancers. Cancer Gene Ther 16:609–619PubMedGoogle Scholar
  94. 94.
    Atherfold PA, Jankowski JA (2006) Molecular biology of Barrett's cancer. Best Pract Res Clin Gastroenterol 20:813–827PubMedGoogle Scholar
  95. 95.
    Brock MV, Gou M, Akiyama Y et al (2003) Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res 9:2912–2919PubMedGoogle Scholar
  96. 96.
    Hao Y, Triadafilopoulos G, Sahbaie P et al (2006) Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarci-noma. Gastroenterology 131:925–933PubMedGoogle Scholar
  97. 97.
    Helm J, Enkemann SA, Coppola D et al (2005) Dediffer en-tiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma. Clin Cancer Res 11:2478–2485PubMedGoogle Scholar
  98. 98.
    Jankowski JA, Wright NA, Meltzer SJ et al (1999) Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am J Pathol 154:965–973PubMedGoogle Scholar
  99. 99.
    Binato M, Gurski RR, Fagundes RB et al (2009) P53 and Ki-67 overexpression in gastroesophageal reflux disease – Barrett's esophagus and adenocarcinoma sequence. Dis Esophagus. 22(7):588–95. Epub 2009 Mar 6PubMedGoogle Scholar
  100. 100.
    Jin Z, Cheng Y, Gu W et al (2009) A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. Cancer Res 69:4112–4115PubMedGoogle Scholar
  101. 101.
    Tischoff I, Tannapfel A (2008) Barrett's esophagus: can biomarkers predict progression to malignancy? Expert Rev Gastroenterol Hepatol 2:653–663PubMedGoogle Scholar
  102. 102.
    Tomizawa Y, Wang KK (2009) Changes in screening, prognosis and therapy for esophageal adenocarcinoma in Barrett's esophagus. Curr Opin Gastroenterol 25:358–365PubMedGoogle Scholar
  103. 103.
    Kaye PV, Haider SA, Ilyas M et al (2009) Barrett's dyspla-sia and the Vienna classification: reproducibility, prediction of progression and impact of consensus reporting and p53 immunohistochemistry. Histopathology 54:699–712PubMedGoogle Scholar
  104. 104.
    Keswani RN, Noffsinger A, Waxman I et al (2006) Clinical use of p53 in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev 15:1243–1249PubMedGoogle Scholar
  105. 105.
    Reid BJ, Blount PL, Rabinovitch PS (2003) Biomarkers in Barrett's esophagus. Gastrointest Endosc Clin N Am 13:369–397PubMedGoogle Scholar
  106. 106.
    Falkenback D, Nilbert M, Oberg S et al (2008) Prognostic value of cell adhesion in esophageal adenocarcinomas. Dis Esophagus 21:97–102PubMedGoogle Scholar
  107. 107.
    Feith M, Stein HJ, Mueller J et al (2004) Malignant degeneration of Barrett's esophagus: the role of the Ki-67 proliferation fraction, expression of E-cadherin and p53. Dis Esophagus 17:322–327PubMedGoogle Scholar
  108. 108.
    Zagorowicz E, Jankowski J (2007) Molecular changes in the progression of Barrett's oesophagus. Postgrad Med J 83:529–535PubMedGoogle Scholar
  109. 109.
    Schuchert MJ, McGrath K, Buenaventura PO (2005) Barrett's esophagus: diagnostic approaches and surveillance. Semin Thorac Cardiovasc Surg 17:301–312PubMedGoogle Scholar
  110. 110.
    Schuchert MJ, Luketich JD (2007) Barrett's esophagus-emerging concepts and controversies. J Surg Oncol 95:185–189PubMedGoogle Scholar
  111. 111.
    Das D, Chilton AP, Jankowski JA (2009) Chemoprevention of oesophageal cancer and the AspECT trial. Recent Results Cancer Res 181:161–169PubMedGoogle Scholar
  112. 112.
    Inoue H, Kajiyama Y, Tsurumaru M (2004) Clinical sig-nificance of bone marrow micrometastases in esophageal cancer. Dis Esophagus 17:328–332PubMedGoogle Scholar
  113. 113.
    Spence GM, Graham AN, Mulholland K et al (2004) Bone marrow micrometastases and markers of angiogenesis in esophageal cancer. Ann Thorac Surg 78:1944–1949; discussion 1950PubMedGoogle Scholar
  114. 114.
    Ryan P, McCarthy S, Kelly J et al (2004) Prevalence of bone marrow micrometastases in esophagogastric cancer patients with and without neoadjuvant chemoradiotherapy. J Surg Res 117:121–126PubMedGoogle Scholar
  115. 115.
    May A, Gunter E, Roth F et al (2004) Accuracy of staging in early oesophageal cancer using high resolution endos-copy and high resolution endosonography: a comparative, prospective, and blinded trial. Gut 53:634–640PubMedGoogle Scholar
  116. 116.
    Shimizu K, Ito K, Matsunaga N et al (2005) Diagnosis of gastric cancer with MDCT using the water-filling method and multiplanar reconstruction: CT-histologic correlation. AJR Am J Roentgenol 185:1152–1158PubMedGoogle Scholar
  117. 117.
    Dalal KM, Woo Y, Kelly K et al (2008) Detection of micro-metastases in peritoneal washings of gastric cancer patients by the reverse transcriptase polymerase chain reaction. Gastric Cancer 11:206–213PubMedGoogle Scholar
  118. 118.
    Liakakos T, Polychronidis A, Bistarakis D et al (2009) Laparoscopic peritoneal cytology: can it affect decision-making for neoadjuvant treatment of gastric cancer? Ann Surg Oncol 16:1072–1073; author reply 1076PubMedGoogle Scholar
  119. 119.
    Birkmeyer JD, Sun Y, Wong SL et al (2007) Hospital volume and late survival after cancer surgery. Ann Surg 245:777–783PubMedGoogle Scholar
  120. 120.
    Casson AG, van Lanschot JJ (2005) Improving outcomes after esophagectomy: the impact of operative volume. J Surg Oncol 92:262–266PubMedGoogle Scholar
  121. 121.
    Kuo EY, Chang Y, Wright CD (2001) Impact of hospital volume on clinical and economic outcomes for esophagec-tomy. Ann Thorac Surg 72:1118–1124PubMedGoogle Scholar
  122. 122.
    Reavis KM, Smith BR, Hinojosa MW et al (2008) Outcomes of esophagectomy at academic centers: an association between volume and outcome. Am Surg 74:939–943PubMedGoogle Scholar
  123. 123.
    Homs MY, v d Gaast A, Siersema PD et al (2006) Chemotherapy for metastatic carcinoma of the esophagus and gastro-esophageal junction. Cochrane Database Syst Rev: CD004063Google Scholar
  124. 124.
    Homs MY, Voest EE, Siersema PD (2009) Emerging drugs for esophageal cancer. Expert Opin Emerg Drugs 14:329–339PubMedGoogle Scholar
  125. 125.
    Finch MD, John TG, Garden OJ et al (1997) Laparoscopic ultrasonography for staging gastroesophageal cancer. Surgery 121:10–17PubMedGoogle Scholar
  126. 126.
    Bollschweiler EH, Monig SP, Hensler K et al (2004) Artificial neural network for prediction of lymph node metastases in gastric cancer: a phase II diagnostic study. Ann Surg Oncol 11:506–511PubMedGoogle Scholar
  127. 127.
    Mitas M, Almeida JS, Mikhitarian K et al (2005) Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR. Clin Cancer Res 11:2205–2214PubMedGoogle Scholar
  128. 128.
    Streitz JM Jr, Madden MT, Marimanikkuppam SS et al (2005) Analysis of protein expression patterns in Barrett's esophagus using MALDI mass spectrometry, in search of malignancy biomarkers. Dis Esophagus 18:170–176PubMedGoogle Scholar
  129. 129.
    Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, Estes N, Haller DG, Ajani J, Kocha W, Minsky BD, Roth JA. (1998) Chemotherapy followed by surgery compared with surgery alone for localized esopha-geal cancer. N Engl J Med. Dec 31;339(27):1979–84PubMedGoogle Scholar
  130. 130.
    Medical Research Council Oesophageal Cancer Working Group. (2002) Surgical resection with or without preopera-tive chemotherapy in oesophageal cancer: a randomised controlled trial. Lancet. May 18;359(9319):1727–33Google Scholar
  131. 131.
    Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants. (2006) Perioperative chemotherapy versus surgery alone for resectable gastroe-sophageal cancer. N Engl J Med. Jul 6;355(1):11–20PubMedGoogle Scholar
  132. 132.
    Urba SG, Orringer MB, Turrisi A, Iannettoni M, Forastiere A, Strawderman M. (2001). Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. Jan 15;19(2):305–13PubMedGoogle Scholar
  133. 133.
    Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. (1996) A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. Aug 15;335(7):462–7. Erratum in: N Engl J Med 1999 Jul 29;341(5):384PubMedGoogle Scholar
  134. 134.
    Burmeister BH, Smithers BM, Gebski V, Fitzgerald L, Simes RJ, Devitt P, Ackland S, Gotley DC, Joseph D, Millar J, North J, Walpole ET, Denham JW; Trans-Tasman Radiation Oncology Group; Australasian Gastro-Intestinal Trials Group. (2005) Surgery alone versus chemoradio-therapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol. Sep;6(9):659–68PubMedGoogle Scholar
  135. 135.
    Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, Estes N, Haller DG, Ajani J, Kocha W, Minsky BD, Roth JA. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med. 1998 Dec 31;339(27):1979–84. PubMed PMID: 9869669PubMedGoogle Scholar
  136. 136.
    Medical Research Council Oesophageal Cancer Working Group. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial. Lancet. 2002 May 18;359(9319):1727–33. PubMed PMID: 12049861Google Scholar
  137. 137.
    Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroe-sophageal cancer. N Engl J Med. 2006 Jul 6;355(1):11–20. PubMed PMID: 16822992PubMedGoogle Scholar
  138. 138.
    Urba SG, Orringer MB, Turrisi A, Iannettoni M, Forastiere A, Strawderman M. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 2001 Jan 15;19(2):305–13. PubMed PMID: 11208820PubMedGoogle Scholar
  139. 139.
    Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med.1996 Aug 15;335(7):462–7. Erratum in: N Engl J Med 1999 Jul 29;341(5):384. PubMed PMID: 8672151PubMedGoogle Scholar
  140. 140.
    Burmeister BH, Walpole ET, Burmeister EA, Thomas J, Thomson DB, Harvey JA,Mark Smithers B, Gotley DC. Feasibility of chemoradiation therapy with protracted infusion of 5-fluorouracil for esophageal cancer patients not suitable for cisplatin. Int J Clin Oncol. 2005 Aug;10(4):256– 61. PubMed PMID: 16136371PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Danny Yakoub
    • 1
  • Oliver Priest
    • 2
  • Akram R. George
    • 2
  • George B. Hanna
    • 2
  1. 1.Department of SurgeryStaten Island University HospitalNew YorkUSA
  2. 2.Department of Biosurgery and Surgical TechnologyImperial College LondonLondonUK

Personalised recommendations