Key Topics in Surgical Research and Methodology

pp 207-228

An Introduction to Animal Research

  • James KinrossAffiliated withDepartment of Biosurgery and Surgical Technology, Imperial College
  • , Lord Ara DarziAffiliated withThe Department of Biosurgery and Surgical Technology, Imperial College London

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Despite advances in computer modelling and bioinformatics, animal models remain a vital component of biomedical research. The growth in this area of work is in part due to the evolution next generation of biotechnologies, which more than ever necessitate the need for in vivo experimentation. An understanding of the principals of animal research therefore remains a necessity for medical researchers as it permits scientific analysis to be interpreted in a more critical and meaningful manner. Initiating and designing an animal experiment can be a daunting process, particularly as the law and legislation governing animal research is complex and new specialist skills must be acquired. This chapter reviews the principles of animal research and provides a practical resource for those researchers seeking to create robust animal experiments that ensure minimal suffering and maximal scientific validity.