An Introduction to Animal Research

  • James Kinross
  • Lord Ara Darzi


Despite advances in computer modelling and bioinformatics, animal models remain a vital component of biomedical research. The growth in this area of work is in part due to the evolution next generation of biotechnologies, which more than ever necessitate the need for in vivo experimentation. An understanding of the principals of animal research therefore remains a necessity for medical researchers as it permits scientific analysis to be interpreted in a more critical and meaningful manner. Initiating and designing an animal experiment can be a daunting process, particularly as the law and legislation governing animal research is complex and new specialist skills must be acquired. This chapter reviews the principles of animal research and provides a practical resource for those researchers seeking to create robust animal experiments that ensure minimal suffering and maximal scientific validity.



The American College of Laboratory Animal Medicine


Animal and Plant Health Inspection Service


Animal Welfare Act


Control of substances hazardous to health


European Coalition for Biomedical Research


The Food and Drug Agency

H & SE

Health and Safety Executive


The Human Fertilisation and Embryology Authority


Institutional Animal Care and Use Committee


Individually ventilated cage


In vitro fertilisation


Laboratory animal allergy


Named animal care and welfare officer


National Institute for Clinical Excellence


Named veterinary surgeon


The Office of Laboratory Animal Welfare


Public Health Service


Personal License under the Scientific (Animal Procedures) Act 1986


Project License under the Scientific (Animal Procedures) Act 1986


Royal Society for the Prevention of Cruelty to Animals


Specified pathogen free


The United States Department of Agriculture


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • James Kinross
    • 1
  • Lord Ara Darzi
    • 2
  1. 1.Department of Biosurgery and Surgical TechnologyImperial CollegeLondonUK
  2. 2.The Department of Biosurgery and Surgical TechnologyImperial College LondonLondonUK

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