An Introduction to Animal Research

  • James Kinross
  • Lord Ara Darzi

Abstract

Despite advances in computer modelling and bioinformatics, animal models remain a vital component of biomedical research. The growth in this area of work is in part due to the evolution next generation of biotechnologies, which more than ever necessitate the need for in vivo experimentation. An understanding of the principals of animal research therefore remains a necessity for medical researchers as it permits scientific analysis to be interpreted in a more critical and meaningful manner. Initiating and designing an animal experiment can be a daunting process, particularly as the law and legislation governing animal research is complex and new specialist skills must be acquired. This chapter reviews the principles of animal research and provides a practical resource for those researchers seeking to create robust animal experiments that ensure minimal suffering and maximal scientific validity.

Abbreviations

ACLAM

The American College of Laboratory Animal Medicine

APHIS

Animal and Plant Health Inspection Service

AWA

Animal Welfare Act

COSHH

Control of substances hazardous to health

ECBR

European Coalition for Biomedical Research

FDA

The Food and Drug Agency

H & SE

Health and Safety Executive

HFEA

The Human Fertilisation and Embryology Authority

IACUC

Institutional Animal Care and Use Committee

IVC

Individually ventilated cage

IVF

In vitro fertilisation

LAS

Laboratory animal allergy

NACWO

Named animal care and welfare officer

NICE

National Institute for Clinical Excellence

NVS

Named veterinary surgeon

OLAW

The Office of Laboratory Animal Welfare

PHS

Public Health Service

PIL

Personal License under the Scientific (Animal Procedures) Act 1986

PPL

Project License under the Scientific (Animal Procedures) Act 1986

RSPCA

Royal Society for the Prevention of Cruelty to Animals

SPF

Specified pathogen free

USDA

The United States Department of Agriculture

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • James Kinross
    • 1
  • Lord Ara Darzi
    • 2
  1. 1.Department of Biosurgery and Surgical TechnologyImperial CollegeLondonUK
  2. 2.The Department of Biosurgery and Surgical TechnologyImperial College LondonLondonUK

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