The Role of a Priori Information in the Minimization of Contact Potentials by Means of Estimation of Distribution Algorithms

  • Roberto Santana
  • Pedro Larrañaga
  • Jose A. Lozano
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4447)


Directed search methods and probabilistic approaches have been used as two alternative ways for computational protein design. This paper presents a hybrid methodology that combines features from both approaches. Three estimation of distribution algorithms are applied to the solution of a protein design problem by minimization of contact potentials. The combination of probabilistic models able to represent probabilistic dependencies with the use of information about residues interactions in the protein contact graph is shown to improve the efficiency of search for the problems evaluated.


estimation of distribution algorithm protein design energy minimization algorithms. 


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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Roberto Santana
    • 1
  • Pedro Larrañaga
    • 1
  • Jose A. Lozano
    • 1
  1. 1.Department of Computer Science and Artificial Intelligence University of the Basque Country, Donostia-San SebastianSpain

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