T1 Hypointense Lesions (Black Holes)

  • Mohammad Ali Sahraian
  • Ernst-Wilhelm Radue
Chapter

Abstract

A black hole (BH) is defined as any abnormal hypointensity as compared with normal-appearing white matter visible on T1-weighted sequences concordant with a region of high signal intensity on T2-weighted images. Black holes are considered to be acute when they coincide with a contrast enhancing lesion (CEL), and to be chronic or persistent when no corresponding CEL exists (Bagnato et al. 2003).

Keywords

Black Hole Multiple Sclerosis Expand Disability Status Scale Axonal Loss Enhance Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Bagnato F, Jeffries N, Richert ND et al (2003) Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years. Brain 126:1782–1789PubMedCrossRefGoogle Scholar
  2. 2.
    Bakshi R, Minagar A, Jaisani Z et al (2005) Imaging of multiple sclerosis: role in neurotherapeutics. NeuroRx 2:277–303PubMedCrossRefGoogle Scholar
  3. 3.
    Bitsch A, Bruck W (2002) MRI-pathological correlates in MS. Int MSJ 8:89–95Google Scholar
  4. 4.
    Goodin DS (2006) Magnetic resonance imaging as a surrogate outcome measure of disability in multiple sclerosis: have we been overly harsh in our assessment? Ann Neurol 59:597–605PubMedCrossRefGoogle Scholar
  5. 5.
    Uhlenbrock D, Sehlen S (1989) The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). Neuroradiology 31:203–212PubMedCrossRefGoogle Scholar
  6. 6.
    Waesberghe JH van, van Walderveen MA, Castelijns JA et al (1998) Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR. AJNR Am J Neuroradiol 19:675–683Google Scholar
  7. 7.
    Walderveen MA van, Truyen L, van Oosten BW et al (1999) Development of hypointense lesions on T1-weighted spin-echo magnetic resonance images in multiple sclerosis: relation to inflammatory activity. Arch Neurol 56:345–451CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Mohammad Ali Sahraian
    • 1
  • Ernst-Wilhelm Radue
    • 2
  1. 1.Department of Neurology, Sina HospitalTehran University of Medical SciencesTehranIran, Islamic Republic of
  2. 2.Head of Department of NeuroradiologyUniversity Hospital BaselBaselSwitzerland

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