Interferon: The 50th Anniversary pp 71-95

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 316)

The Receptor of the Type I Interferon Family

  • G. Uzé
  • G. Schreiber
  • J. Piehler
  • S. Pellegrini

Abstract

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • G. Uzé
    • 1
  • G. Schreiber
    • 2
  • J. Piehler
    • 3
  • S. Pellegrini
    • 4
  1. 1.CNRS UMR 5124University Montpellier IIMontpellier cedex 5France
  2. 2.Department of Biological ChemistryWeizmann Institute of ScienceRehovotIsrael
  3. 3.Institute of Biochemistry, Biocenter N210Johann Wolfgang Goethe UniversityFrankfurt-am-MainGermany
  4. 4.Unit of Cytokine Signaling, CNRS URA 1961Institut PasteurParisFrance

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