Hodgkin and Non-Hodgkin Lymphomas During Pregnancy

  • Patrizia Froesch
  • Volmar Belisario-Filho
  • E. Zucca
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 178)


Malignant lymphomas are classified into Hodgkin (HL) and non-Hodgkin lymphoma (NHL), which comprise 15%–30% and 70%–85% of all lymphomas, respectively.


International Prognostic Index Burkitt Lymphoma Foetal Outcome Therapeutic Abortion Foetal Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    UK Hodgkin’s Lymphoma incidence statistics. Retrieved 13 Mar.2007, from Scholar
  2. 2.
    Jemal A, Murray T, Ward E, et al. (2005) CA Cancer J Clin 55(1): 10–30Google Scholar
  3. 3.
    Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, Rosenberg SA, Coltman CA, Tubiana M (1989) Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol 7(11): 1630–1636PubMedGoogle Scholar
  4. 4.
    Draube A, Behringer K, Diehl V (2006) German Hodgkin’s Lymphoma Study Group Trials: Lessons from the Past and Current Strategies. Clin Lymphoma Myeloma 6: 458–468PubMedCrossRefGoogle Scholar
  5. 5.
    Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43–66PubMedGoogle Scholar
  6. 6.
    Jost LM, Kloke O, Stahel RA (2005) ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of newly diagnosed large cell non-Hodgkin’s lymphoma. Ann Oncol 16 Suppl 1: i58–i59Google Scholar
  7. 7.
    American Cancer Society (2007) Detailed Guide: Lymphoma, Non-Hodgkin’s type: What Are the Key Statistics About Non-Hodgkin Lymphoma? Retrieved 13 Mar.2007, from Scholar
  8. 8.
    SEER Fast Stats Results (2006) Trends (APC) of SEER Incidence Rates by Sex For Non-Hodgkin Lymphoma, Ages 50+, All Races SEER 13 Registries for 1994–2003 and 1999–2003 Age-Adjusted to the 2000 US STD Population. Retrieved 13 Mar 2007, from Scholar
  9. 9.
    American Cancer Society (2007) Cancer Facts & Figures 2007. Atlanta, American Cancer Society. Retrieved 13 Mar 2007, from ( Scholar
  10. 10.
    Pavlidis NA (2002) Coexistence of pregnancy and malignancy. Oncologist 7: 279–287PubMedCrossRefGoogle Scholar
  11. 11.
    Pohlman B, Lyons JA, Macklis RM (1999) Lymphoma in pregnancy. In: Trimble EL, Trimble CL, eds. Cancer Obstetrics and Gynecology. Philadelphia: Lippincott Williams & Wilkins, pp. 202–238Google Scholar
  12. 12.
    Barry RM, Diamond HD, Craver LF (1962) Influence of pregnancy in the course of Hodgkin’s disease. Am J Obstet Gynecol 84: 445–454PubMedGoogle Scholar
  13. 13.
    Jacobs C, Donaldson SS, Rosenberg SA, et al. (1981) Management of the pregnant patient with Hodgkin’s disease. Ann Intern Med 95: 669–675PubMedGoogle Scholar
  14. 14.
    Tawil E, Mercier JP, Dandavino A (1985) Hodgkin’s disease complicating pregnancy. J Can Assoc Radiol 46: 133–137Google Scholar
  15. 15.
    Nisce LZ, Tome MA, He S, et al. (1986) Management of coexisting Hodgkin’s disease and pregnancy. Am J Clin Oncol 9: 146–151PubMedCrossRefGoogle Scholar
  16. 16.
    Gobbi PG, Attardo-Parrinello A, Danesino M, et al. (1984) Hodgkin’s disease and pregnancy. Haematologica 69: 336–341PubMedGoogle Scholar
  17. 17.
    Jouet JP, Buchet-Bouverne B, Fenaux P, et al. (1988) Influence de la grossess sur le développement de la maladie de Hodgkin. Presse Med 17: 423–427PubMedCrossRefGoogle Scholar
  18. 18.
    Lambe M, Ekbom A (1995) Cancers coinciding with childbearing: delayed diagnosis during pregnancy? BMJ 311: 1607–1608PubMedGoogle Scholar
  19. 19.
    Lishner M, Zemlickis D, Sutcliffe SB, et al. (1994) Non-Hodgkin’s lymphoma and pregnancy. Leuk Lymphoma 14: 411–413PubMedGoogle Scholar
  20. 20.
    Ebert U, Loffler H, Kirch W (1997) Cytotoxic therapy and pregnancy. Pharmacol Ther 74: 207PubMedCrossRefGoogle Scholar
  21. 21.
    Aviles A, Neri N (2001) Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clinical Lymphoma 2: 173–177PubMedCrossRefGoogle Scholar
  22. 22.
    Carbonick E, Iacobucci A (2004) Use of chemotherapy during human pregnancy. Lancet Oncol 5: 283–291CrossRefGoogle Scholar
  23. 23.
    Traullé C, Coiffier B (2006) Lymphoma and pregnancy. In: Canellos GP, Lister TA, Young B, eds The Lymphomas, second edition. Philadelphia: Saunders Elsevier, pp. 536–541Google Scholar
  24. 24.
    Dhedin N, Coiffier B (1993) Lymphoma and pregnancy. In: Canellos GP, Lister TA, Young B, eds. The Lymphomas. New York: Elsevier, pp. 549–556Google Scholar
  25. 25.
    Moore DT, Talismi MM (1992) Non-Hodgkin’s lymphoma in pregnancy: a diagnostic dilemma. Case report and review of the literature. J Tenn Med Assoc 85: 467–469PubMedGoogle Scholar
  26. 26.
    Ward FT, Weiss RB (1989) Lymphoma and pregnancy. Semin Oncol 16: 397PubMedGoogle Scholar
  27. 27.
    Catlin EA, Roberts JD, Erana R, et al. (1999) Transplacental transmission of natural-killer-cell lymphoma. N Engl J Med 341: 85–91PubMedCrossRefGoogle Scholar
  28. 28.
    Steiner-Salz D, Yahalom J, Samuelov A, Polliack A (1985) Non-Hodgkin’s lymphoma associated with pregnancy: a report of six cases, with a review of the literature. Cancer 56: 2087PubMedCrossRefGoogle Scholar
  29. 29.
    Spitzer M, Citron M, Ilardi CF, Saxe B (1991) Non-Hodgkin’s lymphoma during pregnancy. Gynecol Oncol 43: 309PubMedCrossRefGoogle Scholar
  30. 30.
    Gelb AB, Vanderijn M, Warnke RA, et al. (1996) Pregnancy associated lymphomas. A clinicopathologic study. Cancer 78: 304–310PubMedCrossRefGoogle Scholar
  31. 31.
    Aviles A, Diaz-Maqueo JC, Torras V, Garcia EL, Guzman R (1990) Non-Hodgkin’s lymphomas and pregnancy: presentation of 16 cases. Gynecol Oncol 37: 335PubMedCrossRefGoogle Scholar
  32. 32.
    Nantel S, Parbbosingh J, Poon MC (1990) Treatment of an aggressive non-Hodgkin’s lymphoma during pregnancy with MACOP-B chemotherapy. Med Pediatr Oncol 18: 143PubMedCrossRefGoogle Scholar
  33. 33.
    Toppenberg KS, Hill DA, Miller DP (1999) Safety of radiographic imaging during pregnancy. Am Fam Physician 59: 1813–1818PubMedGoogle Scholar
  34. 34.
    Pentheroudakis G, Pavlidis N (2006) Cancer and pregnancy: poena magna, not anymore. Eur J Cancer 42: 126–140PubMedCrossRefGoogle Scholar
  35. 35.
    Nicklas AH, Baker ME (2000) Imaging strategies in the pregnant cancer patient. Semin Oncol 27: 623–632PubMedGoogle Scholar
  36. 36.
    Kal HB, Struikmans H (2005) Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 6: 328–333PubMedCrossRefGoogle Scholar
  37. 37.
    Hall EJ (1994) Radiobiology for the radiologist, 4th ed. Philadelphia: JB LippincottGoogle Scholar
  38. 38.
    Rugh R (1962) Low levels of x-irradiation and the early mammalian embryo. Am J Roentgenol 87: 559Google Scholar
  39. 39.
    Portlock CS, Yaholomon J (1999) The management of Hodgkin’s Disese during Pregnancy. In Mauch PM, Armitage JO, Diehl V, Hoppe RT, and Weiss LM, eds. Hodgkin’s Disease. Lippincott Williams & Wilkins, Philadelphia, Chapter 38Google Scholar
  40. 40.
    Bonadonna G, Valagussa P, Santoro A (1986) Alternating non-cross-resistant combination chemotherapy or MOPP in stage IV Hodgkin’s disease. Ann Intern Med 104: 739–746PubMedGoogle Scholar
  41. 41.
    Diehl V, Sieber M, Ruffer U, et al. (1997) BEACOPP: an intensified chemotherapy regimen in advanced Hodgkin’s disease. Ann Oncol 8: 143–148PubMedCrossRefGoogle Scholar
  42. 42.
    Bartlett NL, Rosenberg SA, Hoppe RT, et al. (1995) Brief chemotherapy, Stanford V, and adjuvant radiotherapy for bulky or advanced-stage Hodgkin’s disease: a preliminary report. J Clin Oncol 13: 1080–1088PubMedGoogle Scholar
  43. 43.
    Sutcliffe SB, Chapman RM (1986) Lymphomas and leukemias, in Allen HH, Nisker JA (eds): Cancer in pregnancy. Mt. Kisco, NY, Futura, pp. 135–189Google Scholar
  44. 44.
    Pohlman B, Macklis RM (2000) Lymphoma and pregnancy. Semin Oncol 27: 657–666PubMedGoogle Scholar
  45. 45.
    The International Non-Hodgkin’s Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 329: 987–994Google Scholar
  46. 46.
    Pfreundschuh M, Trumper L, Osterborg A, et al. (2006) CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 7: 379–391PubMedCrossRefGoogle Scholar
  47. 47.
    Coiffier B, Lepage E, Briere J, et al. (2002) CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 346: 235–242PubMedCrossRefGoogle Scholar
  48. 48.
    Herold M, Schnohr S, Bittrich H (2001) Efficacy and safety of a combined rituximab chemotherapy during pregnancy. J Clin Oncol 19: 3439PubMedGoogle Scholar
  49. 49.
    Kimby E, Sverrisdottir A, Elinder G (2004) Safety of rituximab therapy during the first trimester of pregnancy: a case history. Eur J Haematol 72(4): 292–295PubMedCrossRefGoogle Scholar
  50. 50.
    Friedrichs B, Tieman M, Salwender H, et al. (2006) The effects of rituximab treatment during pregnancy on a neonate. Haematologica 91(10): 1426–1427PubMedGoogle Scholar
  51. 51.
    Decker M, Rothermundt C, Hollander G, et al. (2006) Rituximab plus CHOP for treatment of diffuse large B-cell lymphoma during second trimester of pregnancy. Lancet Oncol 7(8): 693–694PubMedCrossRefGoogle Scholar
  52. 52.
    Habermann TM, Witzig TE (2003) Management of lymphoma during pregnancy. In Mauch PM, Armitage JO, Coiffier B, Dalla Favera R, and Harris HL, eds. Non-Hodgkin’s Lymphomas. Lippincott Williams & Wilkins, Philadelphia, Chapter 38Google Scholar
  53. 53.
    Pereg D, Koren G, Lishner M (2003) The treatment of Hodgkin’s and non-Hodgkin’s lymphoma in pregnancy. Haematologica 92 (8): 1230-1237Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Patrizia Froesch
    • 1
  • Volmar Belisario-Filho
    • 1
  • E. Zucca
    • 1
  1. 1.IOSI, Oncology Institute of Southern SwitzerlandBellinzonaSwitzerland

Personalised recommendations