Integrating Mutations Data of the TP53 Human Gene in the Bioinformatics Network Environment

  • Domenico Marra
  • Paolo Romano
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4414)


We present in this paper some new network tools that can improve the accessibility of information on mutations of the TP53 human gene with the aims of allowing for the integration of this data in the growing bioinformatics network environment and of demonstrating a possible methodology for biological data integration. We implemented the IARC TP53 Mutations Database and related subsets in an SRS site, set up some Web Services allowing for a software oriented, programmatic access to this data, created some demo workflows that illustrate how to interact with Web Services and implemented these workflows in the biowep (Workflow Enactment Portal for Bioinformatics) system. In conclusion, we discuss a new flexible and adaptable methodology for data integration in the biomedical research application domain.


data integration molecular biology databases  bioinformatics Web Services XML workflow management systems  workflow enactment portal 


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Copyright information

© Springer Berlin Heidelberg 2007

Authors and Affiliations

  • Domenico Marra
    • 1
  • Paolo Romano
    • 1
  1. 1.Bioinformatics and Structural Proteomics, National Cancer Research Institute, Largo Rosanna Benzi 10, I-16132 GenovaItaly

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