Drugs Which Compromise Testicular Function

Abstract

Cimetidine is effective on Ca2+ influx into sperm cells in vitro. In vivo, it exerts an antiandrogenic effect. During treatment of peptic ulcer and in healthy men, testosterone levels decreased, gonadotropin levels increased and sperm count decreased in a considerable number of men. In contrast, ranitidine, famotidine, pantoprazole and lansoprazole did not demonstrate this effect.