Advertisement

Architecture of CD1 Proteins

  • D. M. Zajonc
  • I. A. Wilson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 314)

Keywords

Binding Groove Microsomal Triglyceride Transfer Protein Lipid Antigen Human CD1b Human CD1d 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, Postle AD, De Libero G, Porcelli SA, Spinozzi F (2005) Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med 202:295–308PubMedCrossRefGoogle Scholar
  2. Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000) Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem 275:37757–37764PubMedCrossRefGoogle Scholar
  3. Angenieux C, Fraisier V, Maitre B, Racine V, van der Wel N, Fricker D, Proamer F, Sachse M, Cazenave JP, Peters P, Goud B, Hanau D, Sibarita JB, Salamero J, de la Salle H (2005) The cellular pathway of CD1e in immature and maturing dendritic cells. Traffic 6:286–302PubMedCrossRefGoogle Scholar
  4. Batuwangala T, Shepherd D, Gadola SD, Gibson KJ, Zaccai NR, Fersht AR, Besra GS, Cerundolo V, Jones EY (2004) The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol 172:2382–2388PubMedGoogle Scholar
  5. Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB (1994) Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature 372:691–694PubMedCrossRefGoogle Scholar
  6. Brigl M, Brenner MB (2004) CD1: Antigen presentation and T cell function. Annu Rev Immunol 22:817–890PubMedCrossRefGoogle Scholar
  7. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS (2004) CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med 10:535–539PubMedCrossRefGoogle Scholar
  8. Calabi F, Jarvis JM, Martin L, Milstein C (1989) Two classes of CD1 genes. Eur J Immunol 19:285–292PubMedCrossRefGoogle Scholar
  9. Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, Briken V, Zajonc DM, Wilson I A, Porcelli S, Moody DB (2006) Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J 25:2989–2999PubMedCrossRefGoogle Scholar
  10. Chiu YH, Jayawardena J, Weiss A, Lee D, Park SH, Dautry-Varsat A, Bendelac A (1999) Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J Exp Med 189:103–110PubMedCrossRefGoogle Scholar
  11. Compostella F, Franchini L, De Libero G, Palmisano G, Ronchetti F, Panza L (2002) CD1a-binding glycosphingolipids stimulating human autoreactive T-cells: synthesis of a family of sulfatides differing in the acyl chain moiety. Tetrahedron 58:8703–8708CrossRefGoogle Scholar
  12. Das H, Sugita M, Brenner MB (2004) Mechanisms of Vδ1 γδ T cell activation by microbial components. J Immunol 172:6578–6586PubMedGoogle Scholar
  13. Dascher CC, Hiromatsu K, Naylor JW, Brauer PP, Brown KA, Storey JR, Behar SM, Kawasaki ES, Porcelli SA, Brenner MB, LeClair KP (1999) Conservation of a CD1 multigene family in the guinea pig. J Immunol 163:5478–5488PubMedGoogle Scholar
  14. De la Salle H, Mariotti S, Angenieux C, Gilleron M, Garcia-Alles LF, Malm D, Berg T, Paoletti S, Maitre B, Mourey L, Salamero J, Cazenave JP, Hanau D, Mori L, Puzo G, De Libero G (2005) Assistance of microbial glycolipid antigen processing by CD1e. Science 310:1321–1324PubMedCrossRefGoogle Scholar
  15. De Libero G, Mori L (2005) Recognition of lipid antigens by T cells. Nat Rev Immunol 5:485–496PubMedCrossRefGoogle Scholar
  16. Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS (2005) Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med 202:529–539PubMedCrossRefGoogle Scholar
  17. Ernst WA, Maher J, Cho S, Niazi KR, Chatterjee D, Moody DB, Besra GS, Watanabe Y, Jensen PE, Porcelli SA, Kronenberg M, Modlin RL (1998) Molecular interaction of CD1b with lipoglycan antigens. Immunity 8:331–340PubMedCrossRefGoogle Scholar
  18. Fischer K, Scotet E, Niemeyer M, Koebernick H, Zerrahn J, Maillet S, Hurwitz R, Kursar M, Bonneville M, Kaufmann SH, Schaible UE (2004) Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc Natl Acad Sci U S A 101:10685–10690PubMedCrossRefGoogle Scholar
  19. Gadola SD, Zaccai NR, Harlos K, Shepherd D, Castro-Palomino JC, Ritter G, Schmidt RR, Jones EY, Cerundolo V (2002) Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains. Nat Immunol 3:721–726PubMedCrossRefGoogle Scholar
  20. Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY (2006) Structure and binding kinetics of three different human CD1d-α-galactosylceramide-specific T cell receptors. J Exp Med 203:699–710PubMedCrossRefGoogle Scholar
  21. Garcia KC, Teyton L, Wilson IA (1999) Structural basis of T cell recognition. Annu Rev Immunol 17:369–397PubMedCrossRefGoogle Scholar
  22. Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruiz Y, Bachi A, Kronenberg M, Wilson IA, Degano M (2005) Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol 175:977–984PubMedGoogle Scholar
  23. Gilleron M, Stenger S, Mazorra Z, Wittke F, Mariotti S, Bohmer G, Prandi J, Mori L, Puzo G, De Libero G (2004) Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J Exp Med 199:649–659PubMedCrossRefGoogle Scholar
  24. Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C 3rd, Teyton L, Bendelac A, Savage PB (2004) Effects of lipid chain lengths in α-galactosylceramides on cytokine release by natural killer T cells. J Am Chem Soc 126:13602–13603PubMedCrossRefGoogle Scholar
  25. Gumperz JE, Brenner MB (2001) CD1-specific T cells in microbial immunity. Curr Opin Immunol 13:471–478PubMedCrossRefGoogle Scholar
  26. Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, Podrebarac T, Koezuka Y, Porcelli SA, Cardell S, Brenner MB, Behar SM (2000) Murine CD1d-restricted T cell recognition of cellular lipids. Immunity 12:211–221PubMedCrossRefGoogle Scholar
  27. Jackman RM, Stenger S, Lee A, Moody DB, Rogers RA, Niazi KR, Sugita M, Modlin RL, Peters PJ, Porcelli SA (1998) The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8:341–351PubMedCrossRefGoogle Scholar
  28. Jahng A, Maricic I, Aguilera C, Cardell S, Halder RC, Kumar V (2004) Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med 199:947–957PubMedCrossRefGoogle Scholar
  29. Joyce S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR (1998) Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science 279:1541–1544PubMedCrossRefGoogle Scholar
  30. Kamada N, Iijima H, Kimura K, Harada M, Shimizu E, Motohashi S, Kawano T, Shinkai H, Nakayama T, Sakai T, Brossay L, Kronenberg M, Taniguchi M (2001) Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int Immunol 13:853–861PubMedCrossRefGoogle Scholar
  31. Kang SJ, Cresswell P (2004) Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells. Nat Immunol 5:175–181PubMedCrossRefGoogle Scholar
  32. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, Koseki H, Taniguchi M (1997) CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278:1626–1629PubMedCrossRefGoogle Scholar
  33. Kinjo Y, Wu D, Kim G, Xing GW, Poles MA, Ho DD, Tsuji M, Kawahara K, Wong CH, Kronenberg M (2005) Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434:520–525PubMedCrossRefGoogle Scholar
  34. Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS, Williamson NA, Smyth MJ, Besra GS, Reid HH, Bharadwaj M, Godfrey DI, Rossjohn J, McCluskey J (2006) A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J Exp Med 203:661–673PubMedCrossRefGoogle Scholar
  35. Koch M, Stronge VS, Shepherd D, Gadola SD, Mathew B, Ritter G, Fersht AR, Besra GS, Schmidt RR, Jones EY, Cerundolo V (2005) The crystal structure of human CD1d with and without α-galactosylceramide. Nat Immunol 8:819–826CrossRefGoogle Scholar
  36. Kronenberg M (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 23:877–900PubMedCrossRefGoogle Scholar
  37. Manolova V, Kistowska M, Paoletti S, Baltariu GM, Bausinger H, Hanau D, Mori L, De Libero G (2006) Functional CD1a is stabilized by exogenous lipids. Eur J Immunol 36:1083–1092PubMedCrossRefGoogle Scholar
  38. Maruoka T, Tanabe H, Chiba M, Kasahara M (2005) Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals. Immunogenetics 57:590–600PubMedCrossRefGoogle Scholar
  39. Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR Jr, Moody DB (2004) Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med 200:1559–1569PubMedCrossRefGoogle Scholar
  40. Mattner J, Debord KL, Ismail N, Goff RD, Cantu C 3rd, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A (2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525–529PubMedCrossRefGoogle Scholar
  41. Miller MM, Wang C, Parisini E, Coletta RD, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford HL, Brenner MB, Dascher CC (2005) Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family. Proc Natl Acad Sci U S A 102:8674–8679PubMedCrossRefGoogle Scholar
  42. Miyamoto K, Miyake S, Yamamura T (2001) A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413:531–534PubMedCrossRefGoogle Scholar
  43. Moody DB (2001) Polyisoprenyl glycolipids as targets of CD1-mediated T cell responses. Cell Mol Life Sci 58:1461–1474PubMedCrossRefGoogle Scholar
  44. Moody DB, Porcelli SA (2003) Intracellular pathways of CD1 antigen presentation. Nat Rev Immunol 3:11–22PubMedCrossRefGoogle Scholar
  45. Moody DB, Reinhold BB, Guy MR, Beckman EM, Frederique DE, Furlong ST, Ye S, Reinhold VN, Sieling PA, Modlin RL, Besra GS, Porcelli SA (1997) Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278:283–286PubMedCrossRefGoogle Scholar
  46. Moody DB, Ulrichs T, Muhlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA (2000) CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404:884–888PubMedCrossRefGoogle Scholar
  47. Moody DB, Briken V, Cheng TY, Roura-Mir C, Guy MR, Geho DH, Tykocinski ML, Besra GS, Porcelli SA (2002) Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat Immunol 3:435–442PubMedGoogle Scholar
  48. Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O’Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB (2004) T cell activation by lipopeptide antigens. Science 303:527–531PubMedCrossRefGoogle Scholar
  49. Moody DB, Zajonc DM, Wilson IA (2005) Anatomy of CD1-lipid antigen complexes. Nat Rev Immunol 5:387–399PubMedCrossRefGoogle Scholar
  50. Oki S, Chiba A, Yamamura T, Miyake S (2004) The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113:1631–1640PubMedCrossRefGoogle Scholar
  51. Rauch J, Gumperz J, Robinson C, Skold M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM (2003) Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell. J Biol Chem 278:47508–47515PubMedCrossRefGoogle Scholar
  52. Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D, Modlin RL, Porcelli SA, Furlong ST, Brenner MB (1999) CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ-T cell pool. J Immunol 162:366–371PubMedGoogle Scholar
  53. Rudolph MG, Stanfield RL, Wilson IA (2006) How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol 24:419–466PubMedCrossRefGoogle Scholar
  54. Salamero J, Bausinger H, Mommaas AM, Lipsker D, Proamer F, Cazenave JP, Goud B, de la Salle H, Hanau D (2001) CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells. J Invest Dermatol 116:401–408PubMedCrossRefGoogle Scholar
  55. Schmieg J, Yang G, Franck RW, Tsuji M (2003) Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide. J Exp Med 198:1631–1641PubMedCrossRefGoogle Scholar
  56. Shamshiev A, Donda A, Carena I, Mori L, Kappos L, De Libero G (1999) Self glycolipids as T-cell autoantigens. Eur J Immunol 29:1667–1675PubMedCrossRefGoogle Scholar
  57. Shamshiev A, Gober HJ, Donda A, Mazorra Z, Mori L, De Libero G (2002) Presentation of the same glycolipid by different CD1 molecules. J Exp Med 195:1013–1021PubMedCrossRefGoogle Scholar
  58. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ et al (1995) CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227–230PubMedCrossRefGoogle Scholar
  59. Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR (2005) Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 35:1692–1701PubMedCrossRefGoogle Scholar
  60. Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB (1999) Separate pathways for antigen presentation by CD1 molecules. Immunity 11:743–752PubMedCrossRefGoogle Scholar
  61. Sugita M, Cernadas M, Brenner MB (2004) New insights into pathways for CD1-mediated antigen presentation. Curr Opin Immunol 16:90–95PubMedCrossRefGoogle Scholar
  62. Van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB (2005) Apolipoprotein-mediated pathways of lipid antigen presentation. Nature 437:906–910PubMedCrossRefGoogle Scholar
  63. Van Rhijn I, Young DC, Im JS, Levery SB, Illarionov PA, Besra GS, Porcelli SA, Gumperz J, Cheng TY, Moody DB (2004) CD1d-restricted T cell activation by nonlipidic small molecules. Proc Natl Acad Sci U S A 101:13578–13583PubMedCrossRefGoogle Scholar
  64. Van Rhijn I, Zajonc DM, Wilson IA, Moody DB (2005) T-cell activation by lipopeptide antigens. Curr Opin Immunol 17:222–229PubMedCrossRefGoogle Scholar
  65. Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006) The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d. J Immunol 176:4888–4893PubMedGoogle Scholar
  66. Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE (2004) Saposin C is required for lipid presentation by human CD1b. Nat Immunol 5:169–174PubMedCrossRefGoogle Scholar
  67. Wu DY, Segal NH, Sidobre S, Kronenberg M, Chapman PB (2003) Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med 198:173–181PubMedCrossRefGoogle Scholar
  68. Wu D, Xing GW, Poles MA, Horowitz A, Kinjo Y, Sullivan B, Bodmer-Narkevitch V, Plettenburg O, Kronenberg M, Tsuji M, Ho DD, Wong CH (2005) Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A 102:1351–1356PubMedCrossRefGoogle Scholar
  69. Wu D, Zajonc DM, Fujio M, Sullivan BA, Kinjo Y, Kronenberg M, Wilson IA, Wong CH (2006) Design of NKT-cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. PNAS 103:3972–3977PubMedCrossRefGoogle Scholar
  70. Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fujiwara N, Arias I, Miyake S, Yamamura T, Chang YT, Besra GS, Porcelli SA (2005) Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. Proc Natl Acad Sci U S A 102:3383–3388PubMedCrossRefGoogle Scholar
  71. Zajonc DM, Elsliger MA, Teyton L, Wilson IA (2003) Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol 4:808–815PubMedCrossRefGoogle Scholar
  72. Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L (2005a) Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol 8:810–818CrossRefGoogle Scholar
  73. Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA (2005b) Molecular mechanism of lipopeptide presentation by CD1a. Immunity 22:209–219PubMedCrossRefGoogle Scholar
  74. Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA (2005c) Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med 202:1517–1526PubMedCrossRefGoogle Scholar
  75. Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA (1997) Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 277:339–345PubMedCrossRefGoogle Scholar
  76. Zhou D, Cantu C 3rd, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A, Teyton L (2004a) Editing of CD1d-boundlipid antigens by endosomal lipid transfer proteins. Science 303:523–527PubMedCrossRefGoogle Scholar
  77. Zhou D, Mattner J, Cantu C 3rd, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L, Bendelac A (2004b) Lysosomal glycosphingolipid recognition by NKT cells. Science 306:1786–1789PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • D. M. Zajonc
    • 1
  • I. A. Wilson
    • 1
  1. 1.Department of Molecular Biology and Skaggs Institute of Chemical BiologyThe Scripps Research InstituteLa JollaUSA

Personalised recommendations