Weakly Supervised Cell Nuclei Detection and Segmentation on Tissue Microarrays of Renal Clear Cell Carcinoma

  • Thomas J. Fuchs
  • Tilman Lange
  • Peter J. Wild
  • Holger Moch
  • Joachim M. Buhmann
Conference paper

DOI: 10.1007/978-3-540-69321-5_18

Part of the Lecture Notes in Computer Science book series (LNCS, volume 5096)
Cite this paper as:
Fuchs T.J., Lange T., Wild P.J., Moch H., Buhmann J.M. (2008) Weakly Supervised Cell Nuclei Detection and Segmentation on Tissue Microarrays of Renal Clear Cell Carcinoma. In: Rigoll G. (eds) Pattern Recognition. DAGM 2008. Lecture Notes in Computer Science, vol 5096. Springer, Berlin, Heidelberg

Abstract

Renal cell carcinoma (RCC) is one of the ten most frequent malignancies in Western societies and can be diagnosed by histological tissue analysis. Current diagnostic rules rely on exact counts of cancerous cell nuclei which are manually counted by pathologists.

We propose a complete imaging pipeline for the automated analysis of tissue microarrays of renal cell cancer. At its core, the analysis system consists of a novel weakly supervised classification method, which is based on an iterative morphological algorithm and a soft-margin support vector machine. The lack of objective ground truth labels to validate the system requires the combination of expert knowledge of pathologists. Human expert annotations of more than 2000 cell nuclei from 9 different RCC patients are used to demonstrate the superior performance of the proposed algorithm over existing cell nuclei detection approaches.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Thomas J. Fuchs
    • 1
    • 3
  • Tilman Lange
    • 1
  • Peter J. Wild
    • 2
  • Holger Moch
    • 2
    • 3
  • Joachim M. Buhmann
    • 1
    • 3
  1. 1.Institute for Computational ScienceETH ZürichSwitzerland
  2. 2.Institute of PathologyUniversity Hospital Zürich, University ZürichSwitzerland
  3. 3.Competence Center for Systems Physiology and Metabolic DiseasesETH Zürich 

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