Nicotine Psychopharmacology pp 113-143

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 192)

Magnetic Resonance Imaging Studies of Cigarette Smoking

  • Allen Azizian
  • John Monterosso
  • Joseph O'Neill
  • Edythe D. London


This chapter reviews studies that have applied magnetic resonance imaging (MRI) toward a better understanding of the neurobiological correlates and consequences of cigarette smoking and nicotine dependence. The findings demonstrate that smokers differ from nonsmokers in regional brain structure and neurochemistry, as well as in activation in response to smoking-related stimuli and during the execution of cognitive tasks. We also review functional neuroimaging studies on the effects of nicotine administration on brain activity, both at rest and during the execution of cognitive tasks, independent of issues related to nicotine withdrawal and craving. Although chronic cigarette smoking is associated with poor cognitive performance, acute nicotine administration appears to enhance cognitive performance and increase neural efficiency in smokers.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Allen Azizian
    • 1
  • John Monterosso
    • 1
  • Joseph O'Neill
    • 1
  • Edythe D. London
    • 2
  1. 1.Department of Psychiatry and Biobehavioral SciencesUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Psychiatry and Biobehavioral Sciences, Department of Molecular and Medical Pharmacology, and Brain Research InstituteUniversity of CaliforniaLos AngelesUSA

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