Biomedical Application of Ca Stable Isotopes
This chapter summarizes the current knowledge on the Ca isotope composition of different tissues and Ca isotope cycling in the human and vertebrate body. The known sites of Ca isotope fractionation and the calcium isotopic composition of different compartments and body fluids are discussed. The first part of this chapter follows the journey of Ca in the body from the input (diet) to the output (urine, feces). Finally, current biomedical applications of Ca isotopes for the detection of bone loss during bed rest studies and during bone cancer are presented.
KeywordsCa metabolism Diet Urine Blood Bed rest studies Bone loss Ca isotope transport model
- Heuser A, Frings-Meuthen P, Rittweger J et al (2011b) Calcium isotopes in human urine under simulated microgravity conditions. Miner Mag 75:1019Google Scholar
- Heuser A, Eisenhauser A, Scholz-Ahrens KE et al (2016) Biological fractionation of stable Ca isotopes in göttingen minipigs as a physiological model for Ca homeostasis in humans. Isot Environ Health Stud doi: 10.1080/10256016.2016.1151017
- Mundy GR, Guise TA (1999) Hormonal control of calcium homeostasis. Clin Chem 45:1347–1352Google Scholar
- WHO Scientific Group on the Prevention and Management of Osteoporosis (2003) Prevention and management of osteoporosis. World Health Organization, GenevaGoogle Scholar