Tissue imaging with shaped femtosecond laser pulses
We developed two methods to access novel nonlinear functional contrast in tissue. Here we present three-dimensional, high-resolution data of two-photon absorption, sum-frequency absorption and self-phase modulation acquired in mounted melanoma cells. This fundamentally new contrast, combined with the technique’s high sensitivity, promises to significantly advance optical methods for tissue characterization and diagnosis.
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- 1.M. C. Fischer, H.C. Liu, C. Li, D. Fu, G. Yurtsever, T. Ye, R. Yasuda, W.S. Warren, Opt. Lett., submitted.Google Scholar