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Tissue imaging with shaped femtosecond laser pulses

  • Warren S. Warren
  • Dan Fu
  • Tong Ye
  • Henry Liu
  • Martin C. Fischer
Part of the Springer Series in Chemical Physics book series (CHEMICAL, volume 88)

Abstract

We developed two methods to access novel nonlinear functional contrast in tissue. Here we present three-dimensional, high-resolution data of two-photon absorption, sum-frequency absorption and self-phase modulation acquired in mounted melanoma cells. This fundamentally new contrast, combined with the technique’s high sensitivity, promises to significantly advance optical methods for tissue characterization and diagnosis.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Warren S. Warren
    • 1
  • Dan Fu
    • 2
  • Tong Ye
    • 1
  • Henry Liu
    • 2
  • Martin C. Fischer
    • 1
  1. 1.Departments of Chemistry, Radiology and Biomedical EngineeringDuke UniversityDurhamUSA
  2. 2.Departments of Chemistry and Electrical EngineeringPrinceton UniversityPrincetonUSA

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