Advertisement

Bioactivity of Essential Oils and Their Components

  • Adolfina R. Koroch
  • H. Rodolfo Juliani
  • Julio A. Zygadlo

5.10 Conclusions

The present review demonstrates that EOs and their components have many functional properties and exert their action in mammals as well as in other organisms (insects, fungi, bacteria and viruses). The synergistic effect of EO components is a promising field that could lead to the optimisation of a given bioactivity. This phenomenon has been observed in many activities, such as those of antimicrobials, antioxidants, analgesics and semiochemicals. EOs are complex mixtures of components that show higher activities than their isolated components; their final activities are due to the combine effects of several minor components. Thus, EOs contain multifunctional components that exert their activities through different mechanisms. EOs and their components may have new applications against various diseases of different origins (cancer, fungal, bacterial or viral), because some of these complex diseases require multiple components and multifunctional therapies.

The natural product industry is actively seeking natural therapeutics, preservatives, repellents and other agents that can replace synthetic compounds. The scientific literature has identified new applications and uses of both traditional and exotic EOs. These applications can ultimately assist growers and rural communities in the developing world to increase interest in their products.

Keywords

Agric Food Hexenyl Acetate Perillyl Alcohol Food Chem Toxicol Linalyl Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rauha J-P, Remes S, Heinonen M, Hopia A, Kahkonen M, Kujala T, Pihlaja K, Vuorela H, Vuorela P (2000) Int J Food Microbiol 56:3CrossRefGoogle Scholar
  2. 2.
    Zygadlo JA, Juliani HR (2000) Curr Top Phytochem 3:203Google Scholar
  3. 3.
    Anonymous (2003) Alberta Agriculture, Food and Rural Development, EdmontonGoogle Scholar
  4. 4.
    Lawrence BM (1993) In: Janick J, Simon JE (eds) New Crops. Wiley, New York, p 620Google Scholar
  5. 5.
    Simon JE, Juliani HR, Letchamo W, Smith M, Goliath J, Graven E, Lewinsohn E, Lewinsohn D, Deschamps C, Dudareva N, Morales M, Picerksky E, Gang D, Rotter D, Raskin I, Vieira R, Ranarivelo L, Rasoanaivo P, Acqueye D (2002) New Aromatic Essential Oils. 5th National Symposium. New Crops and New Uses: Strength in Diversity, Atlanta, Georgia, 10–13 NovemberGoogle Scholar
  6. 6.
    Essawi T, Srour M (2000) J Ethnopharmacol 70:343CrossRefGoogle Scholar
  7. 7.
    Lee HC, Cheng SS, Chang ST (2005) J Sci Food Agric 85:2047CrossRefGoogle Scholar
  8. 8.
    Griffin SG, Wyllie SG, Markham JL, Leach DN (1999) Flavour Fragrance J 14:322CrossRefGoogle Scholar
  9. 9.
    Dorman HJD, Deans SG (2000) J Appl Microbiol 88:308CrossRefGoogle Scholar
  10. 10.
    Kalemba D, Kunicka A (2003) Curr Med Chem 10:813CrossRefGoogle Scholar
  11. 11.
    Daferera DJ, Ziogas BN, Polissiou MG (2000) J Agric Food Chem 48:2576CrossRefGoogle Scholar
  12. 12.
    Gulluce M, Sokmen M, Daferera D, Agar G, Ozkan H, Kartal N, Polissiou M, Sokmen A, Sahin F (2003) J Agric Food Chem 51:3958CrossRefGoogle Scholar
  13. 13.
    Bagamboula CF, Uyttendaele M, Debevere J (2004) Food Microbiol 21:33CrossRefGoogle Scholar
  14. 14.
    Ultee A, Bennik MHJ, Moezelaar R (2002) Appl Environ Microb 68:1561CrossRefGoogle Scholar
  15. 15.
    Lambert RJW, Skandamis PN, Coote PJ, Nychas G-JE (2001) J Appl Microbiol 91:453CrossRefGoogle Scholar
  16. 16.
    Salgueiro LR, Cavaleiro C, Goncalves MJ, da Cunha AP (2003) Planta Med 69:80CrossRefGoogle Scholar
  17. 17.
    Tepe B, Daferera D, Sokmen M, Polissiou M, Sokmen A (2004) J Agric Food Chem 52:1132Google Scholar
  18. 18.
    Friedman M, Henika PR, Mandrell RE (2002) J Food Protect 65:1545Google Scholar
  19. 19.
    Aligiannis N, Kalpoutzakis E, Mitaku S, Chinou IB (2001) J Agric Food Chem 49:4168CrossRefGoogle Scholar
  20. 20.
    Chang ST, Chen PF, Chang SC (2001) J Ethnopharmacol 77:123CrossRefGoogle Scholar
  21. 21.
    Ali N, Mohtar M, Shaari K, Rahmanii M, Ali AM, bin Jantan I (2002) J Essent Oil Res 14:135Google Scholar
  22. 22.
    Simic A, Sokovic MD, Ristic M, Grujic-Jovanovic S, Vukojevic J, Marin PD (2004) Phytother Res 18:713CrossRefGoogle Scholar
  23. 23.
    Ranasinghe L, Jayawardena B, Abeywickrama K (2002) Lett Appl Microbiol 35:208CrossRefGoogle Scholar
  24. 24.
    Wang SY, Chen PF, Chang ST (2005) Bioresource Technol 96:813CrossRefGoogle Scholar
  25. 25.
    Sokovic M, Tzakou O, Pitarokili D, Couladis M (2002) Nahrung-Food 46:317CrossRefGoogle Scholar
  26. 26.
    Baydar H, Sagdic O, Ozkan G, Karadogan T (2004) Food Control 15:169CrossRefGoogle Scholar
  27. 27.
    Aligiannis N, Kalpoutzakis E, Chinou IB, Mitakou S, Gikas E, Tsarbopoulos A (2001) J Agric Food Chem 49:811CrossRefGoogle Scholar
  28. 28.
    Karaman S, Digrak M, Ravid U, Ilcim A (2001) J Ethnopharmacol 76:183CrossRefGoogle Scholar
  29. 29.
    Hernandez T, Canales M, Avila JG, Garcia AM, Martinez A, Caballero J, de Vivar AR, Lira R (2005) J Ethnopharmacol 96:551CrossRefGoogle Scholar
  30. 30.
    Skocibusic M, Bezic N (2004) Phytother Res 18:967CrossRefGoogle Scholar
  31. 31.
    Biavati B, Ozcan M, Piccagilia R (2004) Ann Microbiol 54:393Google Scholar
  32. 32.
    dos Santos FJB, Arimateia J, Lopes D, Cito AMGL, de Oliveira EH, de Lima SG, Reis FD (2004) J Essent Oil Res 16:504Google Scholar
  33. 33.
    Chorianopoulos N, Kalpoutzakis E, Aligiannis N, Mitaku S, Nychas GJ, Haroutounian SA (2004) J Agric Food Chem 52:8261Google Scholar
  34. 34.
    Mirjana S, Nada B (2004) J Essent Oil Res 16:387Google Scholar
  35. 35.
    Marino M, Bersani C, Comi G (2001) Int J Food Microbiol 67:187CrossRefGoogle Scholar
  36. 36.
    Sonboli A, Fakhari A, Kanani MR, Yousefzadi M (2004) Z Naturforsch C 59:777Google Scholar
  37. 37.
    Couladis M, Tzakou O, Kujundzic S, Sokovic M, Mimica-Dukic N (2004) Phytother Res 18:40CrossRefGoogle Scholar
  38. 38.
    Bassole IHN, Ouattara AS, Nebie R, Ouattara CAT, Kabore ZI, Traore SA (2003) Phytochemistry 62:209CrossRefGoogle Scholar
  39. 39.
    Dadalioglu I, Evrendilek GA (2004) J Agric Food Chem 52:8255Google Scholar
  40. 40.
    Tzakou O, Pitarokili D, Chinou IB, Harvala C (2001) Planta Med 67:81CrossRefGoogle Scholar
  41. 41.
    Cha JD, Jeong MR, Jeong SI, Moon SE, Kim JY, Kil BS, Song YH (2005) Planta Med 71:186CrossRefGoogle Scholar
  42. 42.
    Tepe B, Donmez E, Unlu M, Candan F, Daferera D, Vardar-Unlu G, Polissiou M, Sokmen A (2004) Food Chem 84:519CrossRefGoogle Scholar
  43. 43.
    Kalpoutzakis E, Aligiannis N, Mentis A, Mitaku S, Charvala C (2001) Planta Med 67:880CrossRefGoogle Scholar
  44. 44.
    Mourey A, Canillac N (2002) Food Control 13:289CrossRefGoogle Scholar
  45. 45.
    Unlu M, Daferera D, Donmez E, Polissiou M, Tepe B, Sokmen A (2002) J Ethnopharmacol 83:117CrossRefGoogle Scholar
  46. 46.
    Viljoen A, van Vuuren S, Ernst E, Klepser M, Demirci B, Baser H, van Wyk BE (2003) J Ethnopharmacol 88:137CrossRefGoogle Scholar
  47. 47.
    Kordali S, Cakir A, Mavi A, Kilic H, Yildirim A (2005) J Agric Food Chem 53:1408CrossRefGoogle Scholar
  48. 48.
    Pitarokili D, Tzakou O, Loukis A, Harvala C (2003) J Agric Food Chem 51:3294CrossRefGoogle Scholar
  49. 49.
    Belletti N, Ndaguimana M, Sisto C, Guerzoni ME, Lanciotti R, Gardini F (2004) J Agric Food Chem 52:6932CrossRefGoogle Scholar
  50. 50.
    Araujo C, Sousa MJ, Ferreira MF, Leao C (2003) J Food Protect 66:625Google Scholar
  51. 51.
    Ngassapa O, Runyoro DKB, Harvala E, Chinou IB (2003) Flavour Fragrance J 18:221CrossRefGoogle Scholar
  52. 52.
    Martins AP, Salgueiro L, Goncalves MJ, da Cunha AP, Vila R, Canigueral S, Mazzoni V, Tomi F, Casanova J (2001) Planta Med 67:580CrossRefGoogle Scholar
  53. 53.
    Tepe B, Sokmen M, Sokmen A, Daferera D, Polissiou M (2005) J Food Eng 69:335CrossRefGoogle Scholar
  54. 54.
    Oumzil H, Ghoulami S, Rhajaoui M, Ilidrissi A, Fkih-Tetouani S, Faid M, Benjouad A (2002) Phytother Res 16:727CrossRefGoogle Scholar
  55. 55.
    Sibanda S, Chigwada G, Poole M, Gwebu ET, Noletto JA, Schmidt JM, Rea AI, Setzer WN (2004) J Ethnopharmacol 92:107CrossRefGoogle Scholar
  56. 56.
    Duru ME, Ozturk M, Ugur A, Ceylan O (2004) J Ethnopharmacol 94:43CrossRefGoogle Scholar
  57. 57.
    Bouzouita N, Kachouri F, Hamdi M, Chaabouni MM, Ben Aissa R, Zgoulli S, Thonart R, Carlier A, Marlier M, Lognay GC (2005) J Essent Oil Res 17:584Google Scholar
  58. 58.
    Baser KHC, Demirci B, Demirci F, Kocak S, Akinci C, Malyer H, Guleryuz G (2002) Planta Med 68:941CrossRefGoogle Scholar
  59. 59.
    Soylu EM, Yigitbas H, Tok FM, Soylu S, Kurt S, Baysal O, Kaya AD (2005) Z Pflanzenk Pflanzen 112:229Google Scholar
  60. 60.
    Bezic N, Skocibusic M, Dunkic V, Radonic A (2003) Phytother Res 17:1037CrossRefGoogle Scholar
  61. 61.
    Zhu SY, Yang Y, Yu HD, Yue Y, Zou GL (2005) J Ethnopharmacol 96:151CrossRefGoogle Scholar
  62. 62.
    Alvarez-Castellanos PP, Bishop CD, Pascual-Villalobos MJ (2001) Phytochemistry 57:99CrossRefGoogle Scholar
  63. 63.
    Demetzos C, Angelopoulou D, Perdetzoglou D (2002) Biochem Syst Ecol 30:651CrossRefGoogle Scholar
  64. 64.
    Setzer WN, Vogler B, Schmidt JM, Leahy JG, Rives R (2004) Fitoterapia 75:192CrossRefGoogle Scholar
  65. 65.
    Tabanca N, Kirimer N, Demirci B, Demirci F, Baser KHC (2001) J Agric Food Chem 49:4300CrossRefGoogle Scholar
  66. 66.
    Yu HH, Kim YH, Kil BS, Kim KJ, Jeong SI, You YO (2003) Planta Med 69:1159CrossRefGoogle Scholar
  67. 67.
    Kim KJ, Kim YH, Yu HH, Jeong SI, Cha JD, Kil BS, You YO (2003) Planta Med 69:274CrossRefGoogle Scholar
  68. 68.
    Senatore F, Formisano C, Arnold NA, Piozzi F (2005) J Essent Oil Res 17:419Google Scholar
  69. 69.
    Yu JQ, Lei JC, Yu HD, Cai X, Zou GL (2004) Phytochemistry 65:881CrossRefGoogle Scholar
  70. 70.
    Iscan G, Kirimer N, Kurkcuoglu M, Husnu CanBaser K, Demirci F (2002) J Agric Food Chem 50:3943CrossRefGoogle Scholar
  71. 71.
    Viljoen AM, Subramoney S, van Vuuren SF, Baser KHC, Demirci B (2005) J Ethnopharmacol 96:271CrossRefGoogle Scholar
  72. 72.
    Sonboli A, Eftekhar F, Yousefzadi M, Kanani MR (2005) Z Naturforsch C 60:30Google Scholar
  73. 73.
    Delaquis PJ, Stanich K, Girard B, Mazza G (2002) Int J Food Microbiol 74:101CrossRefGoogle Scholar
  74. 74.
    Vardar-Unlu G, Candan F, Sokmen A, Daferera D, Polissiou M, Sokmen M, Donmez E, Tepe B (2003) J Agric Food Chem 51:63CrossRefGoogle Scholar
  75. 75.
    bin Jantan I, Yassin MSM, Chin CB, Chen LL, Sim NL (2003) Pharm Biol 41:392Google Scholar
  76. 76.
    Prashar A, Hili P, Veness RG, Evans CS (2003) Phytochemistry 63:569CrossRefGoogle Scholar
  77. 77.
    Sokovic MD, Ristic M, Grubisic D (2004) Pharm Biol 42:328Google Scholar
  78. 78.
    Staniszewska M, Kula J, Wieczorkiewicz M, Kusewicz D (2005) J Essent Oil Res 17:579Google Scholar
  79. 79.
    Oyedeji OA, Afolayan A (2005) S Afr J Bot 71:114Google Scholar
  80. 80.
    Parveen M, Hasan MK, Takahashi J, Murata Y, Kitagawa E, Kodama O, Iwahashi H (2004) J Antimicrob Chemother 54:46CrossRefGoogle Scholar
  81. 81.
    Al-Burtamani SKS, Fatope MO, Marwah RG, Onifade AK, Al-Saidi SH (2005) J Ethnopharmacol 96:107CrossRefGoogle Scholar
  82. 82.
    Jo C, Park BJ, Chung SH, Kim CB, Cha BS, Byun MW (2004) Food Sci Biotechnol 13:384Google Scholar
  83. 83.
    Jirovetz L, Buchbauer G, Stoyanova AS, Georgiev EV, Damianova ST (2003) J Agric Food Chem 51:3854Google Scholar
  84. 84.
    Haznedaroglu MZ, Karabay U, Zeybek U (2001) Fitoterapia 72:829CrossRefGoogle Scholar
  85. 85.
    Lis-Balchin M, Ochocka RJ, Deans SG, Asztemborska M, Hart S (1999) J Essent Oil Res 11:393Google Scholar
  86. 86.
    Aligiannis N, Kalpoutzakis E, Kyriakopoulou I, Mitaku S, Chinou IB (2004) Flavour Fragrance J 19:320CrossRefGoogle Scholar
  87. 87.
    Rotman A, Ahumada O, Demo MS, Oliva MD, Turina AV, Lopez ML, Zygadlo JA, (2003) Flavour Fragrance J 18:211CrossRefGoogle Scholar
  88. 88.
    de Carvalho PM, Rodrigues RFO, Sawaya ACHF, Marques MOM, Shimizu MT (2004) J Ethnopharmacol 95:297CrossRefGoogle Scholar
  89. 89.
    Canillac N, Mourey A (2001) Food Microbiol 18:261CrossRefGoogle Scholar
  90. 90.
    Martins AP, Salgueiro LR, Goncalves MJ, da Cunha AP, Vila R, Caniguerl SC (2003) Planta Med 69:77CrossRefGoogle Scholar
  91. 91.
    Hammer KA, Carson CF, Riley TV (2003) J Appl Microbiol 95:853CrossRefGoogle Scholar
  92. 92.
    Cakir A, Kordali S, Kilic H, Kaya E (2005) Biochem Syst Ecol 33:245CrossRefGoogle Scholar
  93. 93.
    Cheng SS, Lin HY, Chang ST (2005) J Agric Food Chem 53:614CrossRefGoogle Scholar
  94. 94.
    Cakir A, Kordali S, Zengin H, Izumi S, Hirata T (2004) Flavour Fragrance J 19:62CrossRefGoogle Scholar
  95. 95.
    Juliani HR, Biurrun F, Koroch AR, Oliva MM, Demo MS, Trippi VS, Zygadlo JA (2002) Planta Med 68:762CrossRefGoogle Scholar
  96. 96.
    Martins AP, Salgueiro UR, Goncalves MJ, Vila R, Canigueral S, Tomi F, Casanova J (2005) J Essent Oil Res 17:239Google Scholar
  97. 97.
    Chang ST, Wang SY, Wu CL, Chen PF, Kuo YH (2000) Holzforschung 54:241CrossRefGoogle Scholar
  98. 98.
    Cheng SS, Wu CL, Chang HT, Kao YT, Chang ST (2004) J Chem Ecol 30:1957CrossRefGoogle Scholar
  99. 99.
    Inoue Y, Shiraishi A, Hada T, Hirose K, Hamashima H, Shimada J (2004) FEMS Microbiol Lett 237:325Google Scholar
  100. 100.
    Wang SY, Wu CL, Chug FH, Chien SC, Kuo YH, Shyur LF, Chang ST (2005) Holzforschung 59:295CrossRefGoogle Scholar
  101. 101.
    Yayli N, Yasar A, Gulec C, Usta A, Kolayli S, Coskuncelebi K, Karaoglu S (2005) Phytochemistry 66:1741CrossRefGoogle Scholar
  102. 102.
    Lago JHG, de Avila P, de Aquino EM, Moreno PRH, Ohara MT, Limberger RP, Apel MA, Henriques AT (2004) Flavour Fragrance J 19:448CrossRefGoogle Scholar
  103. 103.
    Barrero AF, del Moral LFQ, Lara A, Herrador MM (2005) Planta Med 71:67CrossRefGoogle Scholar
  104. 104.
    Solis C, Becerra J, Flores C, Robledo J, Silva M (2004) J Chil Chem Soc 49:157CrossRefGoogle Scholar
  105. 105.
    Becerra J, Flores C, Mena J, Aqueveque P, Alarcon J, Bittner M, Hernandez V, Hoeneisen M, Ruiz E, Silva M (2002) Bol Soc Chil Quim 47:151Google Scholar
  106. 106.
    Inoue Y, Hada T, Shiraishi A, Hirose K, Hamashima H, Kobayashi S (2005) Antimicrob Agents Chemother 49:1770CrossRefGoogle Scholar
  107. 107.
    Cotoras M, Garcia C, Lagos C, Folch C, Mendoza L (2001) Bol Soc Chil Quim 46:433Google Scholar
  108. 108.
    Cotoras M, Folch C, Mendoza L (2004) J Agric Food Chem 52:2821CrossRefGoogle Scholar
  109. 109.
    Kim JW, Huh JE, Kyung SH, Kyung KH (2004) Food Sci Biotechnol 13:235Google Scholar
  110. 110.
    Kim JW, Kim YS, Kyung KH (2004) J Food Protect 67:499Google Scholar
  111. 111.
    Burt S (2004) Int J Food Microbiol 94:223CrossRefGoogle Scholar
  112. 112.
    Mastelic J, Politeo O, Jerkovic I, Radosevic N (2005) Chem Nat Compd 41:35CrossRefGoogle Scholar
  113. 113.
    Rivera-Carriles K, Argaiz A, Palou E, Lopez-Malo A (2005) J Food Protect 68:602Google Scholar
  114. 114.
    Ultee A, Slump RA, Steging G, Smid EJ (2000) J Food Protect 63:620Google Scholar
  115. 115.
    Aggarwal KK, Khanuja SPS, Ahmad A, Kumar TRS, Gupta VK, Kumar S (2002) Flavour Fragrance J 17:59CrossRefGoogle Scholar
  116. 116.
    Cimanga K, Kambu K, Tona L, Apers S, De Bruyne T, Hermans N, Totte J, Pieters L, Vlietinck AJ (2002) J Ethnopharmacol 79:213CrossRefGoogle Scholar
  117. 117.
    Cox SD, Mann CM, Markham JL (2001) J Appl Microbiol 91:492CrossRefGoogle Scholar
  118. 118.
    Carson CF, Mee BJ, Riley TV (2002) Antimicrob Agents Chemother 46:1914CrossRefGoogle Scholar
  119. 119.
    Cox SD, Mann CM, Markham JL, Bell HC, Gustafson JE, Warmington JR, Wyllie SG (2000) J Appl Microbiol 88:170CrossRefGoogle Scholar
  120. 120.
    Walsh SE, Maillard J-Y, Russell AD, Catrenich CE, Charbonneau DL, Bartolo RG (2003) J Appl Microbiol 94:240CrossRefGoogle Scholar
  121. 121.
    Lucini EI (2004) PhD Thesis, Universidad Nacional de Córdoba, ArgentinaGoogle Scholar
  122. 122.
    Holley RA, Patel D (2005) Food Microbiol 22:273CrossRefGoogle Scholar
  123. 123.
    Rios JL, Recio MC (2005) J Enthopharmacol 100:80CrossRefGoogle Scholar
  124. 124.
    Jasim SAA, Naji MA (2003) J Appl Microbiol 95:412CrossRefGoogle Scholar
  125. 125.
    Schnitzler P, Schon K, Reichling J (2001) Pharmazie 56:343Google Scholar
  126. 126.
    De Logu A, Loy G, Pellerano ML, Bonsignore L, Schivo ML (2000) Antivir Res 48:177CrossRefGoogle Scholar
  127. 127.
    Valenti D, De Logu A, Loy G, Sinico C, Bonsignore L, Cottiglia F, Garau D, Fadda AM (2001) J Liposome Res 11:73CrossRefGoogle Scholar
  128. 128.
    Sinico C, De Logu A, Lai F, Valenti D, Manconi M, Loy G, Bonsignore L, Fadda AM (2005) Eur J Pharm Biopharm 59:161CrossRefGoogle Scholar
  129. 129.
    Garcia CC, Talarico L, Almeida N, Colombres S, Duschatzky C, Damonte EB (2003) Phytother Res 17:1073CrossRefGoogle Scholar
  130. 130.
    Duschatzky CB, Possetto ML, Talarico LB, García CC, Michis F, Almeida NV, De Lampasona MP, Schuff C, Damonte EB (2005) Antivir Chem Chemother 16:247Google Scholar
  131. 131.
    Schuhmacher A, Reichling J, Schnitzler P (2003) Phytomedicine 10:504CrossRefGoogle Scholar
  132. 132.
    Minami M, Kita M, Nakaya T, Yamamoto T, Kuriyama H, Imanishi J (2003) Microbiol Immunol 47:681Google Scholar
  133. 133.
    Marongiu B, Porcedda S, Caredda A, De Gioannis B, Vargiu L, La Colla P (2003) Flavour Fragrance J 18:390CrossRefGoogle Scholar
  134. 134.
    Burke BE, Baillie JE, Olson RD (2004) Biomed Pharmacother 58:245CrossRefGoogle Scholar
  135. 135.
    Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC (2005) Clin Exp Pharmacol P 32:811CrossRefGoogle Scholar
  136. 136.
    Yang ZC, Wang BC, Yang XS, Wang Q (2005) Colloids Surf B 43:198CrossRefGoogle Scholar
  137. 137.
    Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M (1999) Antivir Res 43:79CrossRefGoogle Scholar
  138. 138.
    Farag RS, Shalaby AS, El-Baroty GA, Ibrahim NA, Ali MA, Hassan EM (2004) Phytother Res 18:30CrossRefGoogle Scholar
  139. 139.
    Ruberto G, MT Baratta (2000) Food Chem 69:167CrossRefGoogle Scholar
  140. 140.
    Madsen HL, Bertelsen G (1995) Trends Food Sci Technol 6:271CrossRefGoogle Scholar
  141. 141.
    Rice-Evans CA, NJ Miller, G, Paganga (1996) Free Radical Biol Med 20:933CrossRefGoogle Scholar
  142. 142.
    Dragland S, Senoo H, Wake K, Holte K, Blomhoff R (2003) J Nutr 133:1286Google Scholar
  143. 143.
    Pietta PG (2000) J Nat Prod 63:1035CrossRefGoogle Scholar
  144. 144.
    Kwang-Geun L, Takayuki S (2001) Food Chem 74:443CrossRefGoogle Scholar
  145. 145.
    Sanchez-Moreno C (2002) Food Sci Technol Int 8:121CrossRefGoogle Scholar
  146. 146.
    Choi HS, Song HS, Ukeda H, Sawamura M (2000) J Agric Food Chem 48:4156CrossRefGoogle Scholar
  147. 147.
    Re R, Pellegrini R, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Free Radical Biol Med 26:1231CrossRefGoogle Scholar
  148. 148.
    Benzie IFF, JJ Strain (1996) Anal Biochem 239:70CrossRefGoogle Scholar
  149. 149.
    Dorman HJD, Figueiredo AC, Barroso JG, Deans SG (2000) Flavour Fragrance J 15:12CrossRefGoogle Scholar
  150. 150.
    Grassmann J, Hippeli S, Vollmann R, Elstner EF (2003) J Agric Food Chem 51:7576CrossRefGoogle Scholar
  151. 151.
    Koleva TA, van Beek JP, Linssen H, de Groot A, Evstatieva LN (2002) Phytochem Anal 13:8CrossRefGoogle Scholar
  152. 152.
    Sacchetti G, Maietti S, Muzzoli M, Scaglianti M, Manfredini S, Radice M, Bruni R (2005) Food Chem 91:621CrossRefGoogle Scholar
  153. 153.
    Burits M, Bucar F (2000) Phytother Res 14:323CrossRefGoogle Scholar
  154. 154.
    Foti MC, Ingold KU (2003) J Agric Food Chem 51:2758CrossRefGoogle Scholar
  155. 155.
    El-Ghorab AH, Mansour AF, El-Massry KF (2004) Flavour Fragrance J 19:54CrossRefGoogle Scholar
  156. 156.
    Ruberto G, Baratta MT, Deans SG, Dorman HJD (2000) Planta Med 66:687CrossRefGoogle Scholar
  157. 157.
    Singh G, Marimuthu R, De Heluani CS, Catalan C (2005) J Food Sci 70:M141CrossRefGoogle Scholar
  158. 158.
    Kim HJ, Chen F, Wu CQ, Wang X, Chung HY, Jin ZY (2004) J Agric Food Chem 52:2849CrossRefGoogle Scholar
  159. 159.
    Mimica-Dukic N, Bozin B, Sokovic M, Simin N (2004) J Agric Food Chem 52:2485CrossRefGoogle Scholar
  160. 160.
    Menut C, Bessiere JM, Samate D, Djibo AK, Buchbauer G, Schopper B (2000) J Essent Oil Res 12:207Google Scholar
  161. 161.
    Teissedre P L, Waterhouse AL (2000) J Agric Food Chem 48:3801CrossRefGoogle Scholar
  162. 162.
    Juliani HR, Simon JE, Ramboatiana MMR, Behra O, Garvey AS, Raskin I (2004) Acta Hortic 629:77Google Scholar
  163. 163.
    Lee KG, Shibamoto T (2001) Food Chem 74:443CrossRefGoogle Scholar
  164. 164.
    Lee KG, Shibamoto T (2001) Food Chem Toxicol 39:1199CrossRefGoogle Scholar
  165. 165.
    Sacchetti G, Medici A, Maietti S, Radice N, Muzzoli M, Manfredini S, Braccioli E, Bruni R (2004) J Agric Food Chem 52:3486CrossRefGoogle Scholar
  166. 166.
    Mimica-Dukic N, Bozin B, Sokovic M, Mihajlovic B, Matavulj M (2003) Planta Med 69:413CrossRefGoogle Scholar
  167. 167.
    Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sokmen A, Akpulat HA (2003) J Ethnopharmacol 87:215CrossRefGoogle Scholar
  168. 168.
    Lee KG, Shibamoto T (2001) J Agric Food Chem 81:1573CrossRefGoogle Scholar
  169. 169.
    Lado C, Then M, Varga I, Szoke E, Szentmihalyi K (2004) Z Naturforsch C 59:354Google Scholar
  170. 170.
    Puertas-Mejia M, Hillebrand S, Stashenko E, Winterhalter P (2002) Flavour Fragrance J 17:380CrossRefGoogle Scholar
  171. 171.
    Agnaniet H, Makani T, Akagah A, Menut C, Bessiere JM (2005) Flavour Fragrance J 20:34CrossRefGoogle Scholar
  172. 172.
    Tepe B, Sokmen M, Akpulat HA, Daferera D, Polissiou M, Sokmen A (2005) J Food Eng 66:447CrossRefGoogle Scholar
  173. 173.
    Sokmen A, Gulluce M, Akpulat HA, Daferera D, Tepe B, Polissiou M, Sokmen M, Sahin F (2004) Food Control 15:627CrossRefGoogle Scholar
  174. 174.
    Sokmen M, Serkedjieva J, Daferera D, Gulluce M, Polissiou M, Tepe B, Akpulat HA, Sahin F, Sokmen A (2004) J Agric Food Chem 52:3309CrossRefGoogle Scholar
  175. 175.
    Sawa T, Nakao M, Akaike T, Ono K, Maeda H (1999) J Agric Food Chem 47:397CrossRefGoogle Scholar
  176. 176.
    Karioti A, Hadjipavlou-Litina D, Mensah MLK, Fleischer TC, Skaltsa H (2004) J Agric Food Chem 52:8094Google Scholar
  177. 177.
    Yildirim A, Cakir A, Mavi A, Yalcin M, Fauler G, Taskesenligil Y (2004) Flavour Fragrance J 19:367CrossRefGoogle Scholar
  178. 178.
    Anonymous (1983) Fed Reg 46:5852Google Scholar
  179. 179.
    Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A, Ghelardini C (2002) Neuroscience Lett 322:146CrossRefGoogle Scholar
  180. 180.
    Galeotti N, Ghelardini C, Di Cesare Mannelli L, Mazzanti G, Baghiroli L, Bartolini A, (2000) Planta Med 66:1Google Scholar
  181. 181.
    Eccles R (1994) J Pharm Pharmacol 46:18Google Scholar
  182. 182.
    Sidell N, Verity MA, Nord EP (1990) J Cell Physiol 142:410CrossRefGoogle Scholar
  183. 183.
    Petersen M, Wagner G, Pierau FK (1989) Naunyn Schmiedebergs Arch Pharmacol 339:184CrossRefGoogle Scholar
  184. 184.
    Swandulla D, Schafer K, Lux HD (1986) Neurosci Lett 68:23CrossRefGoogle Scholar
  185. 185.
    Swandulla D, Carbone E, Shafer K, Lux HD (1987) Pflugers Arch 409:52CrossRefGoogle Scholar
  186. 186.
    Hong CZ, Shellock FG (1991) Am J Phys Med Rehabil 70:29CrossRefGoogle Scholar
  187. 187.
    White JR (1973) Phys Ther 53:956Google Scholar
  188. 188.
    Green BG (1992) Somatosens Mot Res 9:235Google Scholar
  189. 189.
    Green BG (1996) J Toxicol Cutan Ocul Toxicol 15:277Google Scholar
  190. 190.
    Green BG (1991) Somatosens Mot Res 8:301CrossRefGoogle Scholar
  191. 191.
    Green BG, McAuliffe BL (2000) Phys Behav 68:631CrossRefGoogle Scholar
  192. 192.
    Cliff MA, Green BG (1994) Physiol Behav 56:1021CrossRefGoogle Scholar
  193. 193.
    Cliff MA, Green BG (1996) Physiol Behav 59:487CrossRefGoogle Scholar
  194. 194.
    Green BG (1986) Physiol Behav 38:833CrossRefGoogle Scholar
  195. 195.
    Bromm B, Scharein E, Darsow U, Ring J (1995) Neurosci Lett 187:157CrossRefGoogle Scholar
  196. 196.
    Melton FM, Shelley WB (1950) J Invest Dermatol 15:325CrossRefGoogle Scholar
  197. 197.
    Yosipovitch G, Szolar C, Hui XY, Maibach H (1996) Arch Dermatol Res 288:245Google Scholar
  198. 198.
    Laude EA, Morice AH, Grattan TJ (1994) Pulmonary Pharmacol 7:179CrossRefGoogle Scholar
  199. 199.
    Morice AH, Marshall AE, Higgins KS, Grattan TJ (1994) Thorax 49:1024Google Scholar
  200. 200.
    Barocelli E, Calcina F, Chiavarini M, Impicciatore M, Bruni R, Bianchi A, Ballabeni V (2004) Life Sci 76:213CrossRefGoogle Scholar
  201. 201.
    Peana AT, De Montis MG, Nieddu E, Spano MT, D’Aquila PS, Pippia P (2004) Eur J Pharmacol 485:165CrossRefGoogle Scholar
  202. 202.
    Letizia CS, Cocchiara J, Lalko J (2003) Food Chem Toxicol 41:943CrossRefGoogle Scholar
  203. 203.
    Letizia CS, Cocchiara J, Lalko J (2003) Food Chem Toxical 41:965CrossRefGoogle Scholar
  204. 204.
    Peana AT, D’Aquila PS, Chessa ML, Moretti MD, Serra G, Pippia P (2003) Eur J Pharmacol 460:37CrossRefGoogle Scholar
  205. 205.
    Peana AT, D’Aquila PS, Panin F, Serra G, Pippia P, Moretti MD (2002) Phytomedicine 9:721CrossRefGoogle Scholar
  206. 206.
    Santos FA, Rao VSN (2000) Phyt Res 14:240CrossRefGoogle Scholar
  207. 207.
    Savelev S, Okello E, Perry NS, Wilkins RM, Perry EK (2003) Pharmacol Biochem Behav 75:661CrossRefGoogle Scholar
  208. 208.
    Santos FA, Rao VS (2001) Dig Dis Sci 46:331CrossRefGoogle Scholar
  209. 209.
    Ballabeni V, Tognolini M, Chiavarini M, Impicciatore M, Bruni R, Bianchi A, Barocelli E (2004) Phytomedicine 11:596CrossRefGoogle Scholar
  210. 210.
    Hajhashemi V, Ghannadi A, Sharif B (2003) J Ethnopharmacol 89:67CrossRefGoogle Scholar
  211. 211.
    Amabeoku GJ, Eagles P, Scott G, Mayeng I, Springfield E (2001) J Ethnopharmacol 75:117CrossRefGoogle Scholar
  212. 212.
    Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN (1999) J Ethnopharmacol 65:21CrossRefGoogle Scholar
  213. 213.
    Silva J, Abebe W, Sousa SM, Duarte VG, Machado MIL, Matos FJA (2003) J Ethnopharmacol 89:277CrossRefGoogle Scholar
  214. 214.
    Gulcin I, Buyukokuroglu ME, Oktay M, Kufrevioglu OI (2003) J Ethnopharmacol 86:51CrossRefGoogle Scholar
  215. 215.
    Abena AA, Diatewa M, Gakosso G, Gbeassor M, Hondi Assah T, Ouamba JM (2003) Fitoterapia 74:231CrossRefGoogle Scholar
  216. 216.
    Zygadlo JA, Juliani HR (2003) In: Majundar DK, Govil JN, Singh VK (eds) Phytochemistry and Pharmacology II, vol 8. Stadium, Houston, p 273Google Scholar
  217. 217.
    Meister A, Bernhardt G, Christoffel V, Buschauer A (1999) Planta Med 65:512CrossRefGoogle Scholar
  218. 218.
    Juliani H R, Wang M, Moharram H, Asante-Dartey J, Acquaye D, Koroch AR, Simon JE (2005) In: Wang M, Shengmin S, Hwang LS, Ho CT (eds) Challenges in Chemistry and Biology of Herbal Research. ACS Symposium Series 925. American Chemical Society, Washington, p 126Google Scholar
  219. 219.
    Shen J, Niijima A, Tanida M, Horii Y, Maeda K, Nagai K (2005) Neurosci Lett 383:188CrossRefGoogle Scholar
  220. 220.
    Triadafilopoulos G, Tsang HP (1996) Am J Gastroenterol 91:2224Google Scholar
  221. 221.
    Van De Graaff KM, Fox SF (1995) Concepts of human anatomy and physiology. Brown, DubuqueGoogle Scholar
  222. 222.
    Tanida M, Niijima A, Shen J, Nakamura T, Nagai K (2005) Brain Res 1058:44CrossRefGoogle Scholar
  223. 223.
    Shen J, Niijima A, Tanida M, Horii Y, Maeda K, Nagai K (2005) Neurosci Lett 380:289CrossRefGoogle Scholar
  224. 224.
    Coelho-de-Souza A N, Criddle DN, Leal-Cardoso JH (1998) Phytother Res 12:189CrossRefGoogle Scholar
  225. 225.
    Hajhashemi V, Sadraei H, Ghannadi AR, Mohseni M (2000) J Ethnopharmacol 71:187CrossRefGoogle Scholar
  226. 226.
    Sadraei H, Asghari GR, Hajhashemi V, Kolagar A, Ebrahimi M (2001) Phytomedicine 8:370CrossRefGoogle Scholar
  227. 227.
    Cruz T, Cabo MM, Jiménez J, Zarzuelo A (1990) Fitoterapia 61:247Google Scholar
  228. 228.
    Al-Zuhair H, el-Sayeh B, Ameen HA, al-Shoora H (1996) Pharmacol Res 34:79CrossRefGoogle Scholar
  229. 229.
    Astudillo A, Hong E, Bye R, Navarrete A (2004) Phytother Res 18:102CrossRefGoogle Scholar
  230. 230.
    Magalhaes PJC, Criddle DN, Tavares RA, Melo EM, Mota TL, Leal-Cardoso JH (1998) Phytother Res 12:172CrossRefGoogle Scholar
  231. 231.
    Sadraei H, Asghari G, Naddafi A (2003) Phytother Res 17:645CrossRefGoogle Scholar
  232. 232.
    Lis-Balchin M, Patel J, Hart S (1998) Phytother Res 12:215CrossRefGoogle Scholar
  233. 233.
    Lis-Balchin M, Hart S (1999) Phytother Res 13:540CrossRefGoogle Scholar
  234. 234.
    Camara CC, Nascimento NRF, Macedo-Filho CL, Almeida FBS, Fonteles MC (2003) Planta Med 69:1080CrossRefGoogle Scholar
  235. 235.
    Sadraei H, Asghari G, Naddafi A (2003) Phytother Res 17:645CrossRefGoogle Scholar
  236. 236.
    Hills JM, Aaronson PI (1991) Gastroenterology 101:55Google Scholar
  237. 237.
    Van Den Broucke C, Lemli JA (1982) Planta Med 38:188Google Scholar
  238. 238.
    Uchiyama T, Chess-Williams R (2004) J Smooth Muscle Res 40:237CrossRefGoogle Scholar
  239. 239.
    Micklefield GH, Greving I, May B (2000) Phytother Res 14:20CrossRefGoogle Scholar
  240. 240.
    Van de Graaf KM, Fox SM (1995) Fundamentals of Anatomy and Physiology, 4th edn. Brown, DubuqueGoogle Scholar
  241. 241.
    Cavanagh HMA, Wilkinson JM (2002) Phytother Res 16:301CrossRefGoogle Scholar
  242. 242.
    Leiss O, von Bergmann K (1985) Gut 26:32Google Scholar
  243. 243.
    Avato P, De Ruvo C, Cellamare S, Carotti A, Mazzoccoli M, Siro-Brigiani G (1998) Pharm Biol 36:335Google Scholar
  244. 244.
    Trabace L, Avato P, Mazzoccoli M, Siro-Brigiani G (1994) Phytother Res 8:305CrossRefGoogle Scholar
  245. 245.
    Lin CC, Yen MH, Lo TS, Lin JM (1998) J Ethnopharmacol 60:9CrossRefGoogle Scholar
  246. 246.
    Sai-Kato K, Umemura T Takagi A, Hasegawa R, Tanimura A, Kurokawa Y (1995) Food Chem Toxicol 33:877CrossRefGoogle Scholar
  247. 247.
    Conti M, Malandrino S, Magistretti MJ (1992) Jpn J Pharmacol 60:315Google Scholar
  248. 248.
    Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K (2003) J Agric Food Chem 51:1560CrossRefGoogle Scholar
  249. 249.
    Utrilla MP, Navarro MC, Jimenez J, Montilla MP, Martin A (1995) J Nat Prod 58:1749CrossRefGoogle Scholar
  250. 250.
    Alam K, Nagi MN, Baday OA, Al-shabanah OA, Al-Rikabi AC, Al-Bekairi AM (1999) Pharmacol Res 40:159CrossRefGoogle Scholar
  251. 251.
    Ozbek H, Ugras S, Dulger H, Bayram I, Tuncer I, Ozturk G, Ozturk A (2003) Fitoterapia 74:317CrossRefGoogle Scholar
  252. 252.
    Peana A, Satta M, Moretti MDL, Orecchioni M (1994) Planta Med 60:478–479.CrossRefGoogle Scholar
  253. 253.
    Fahim FA, Esmat AY, Fadel HM, Hassan KF (1999) Int J Food Sci Nutr 50:413CrossRefGoogle Scholar
  254. 254.
    Matsunaga T, Hasegawa C, Kawasuji T, Suzuki H, Saito H, Sagioka T, Takahashi R, Tsukamoto H, Morikawa T, Akiyama T (2000) Biol Pharm Bull 23:595Google Scholar
  255. 255.
    Perez S, Zavala MA, Vargas R, Perez C, Perez RM, (1998). Phytother Res 12:S45CrossRefGoogle Scholar
  256. 256.
    Hahn WC, Weinberg RA (2002) J Med 347:1593Google Scholar
  257. 257.
    Bradlow HL, Sepkovic DW (2002) Ann N Y Acad Sci 963:247CrossRefGoogle Scholar
  258. 258.
    Darmon N, Khlar M (2001) Public Health Nutr 4:163Google Scholar
  259. 259.
    Greenwald P, Clifford CK, Milner JA (2001) Eur J Cancer 37:948CrossRefGoogle Scholar
  260. 260.
    da Rocha AB, Lopes RM, Schwartsmann G (2001) Curr Opin Pharmacol 1:364CrossRefGoogle Scholar
  261. 261.
    Trichopoulou A, Lagiou P, Keper H, Trichopoulo D (2000) Cancer Epidemol Biomarkers Prev 9:869Google Scholar
  262. 262.
    Sugimura T (2000) Carcinogenesis 21:387CrossRefGoogle Scholar
  263. 263.
    Crowell PL (1999) J Nutr 129:775SGoogle Scholar
  264. 264.
    Crosignani P, Russo A, Tagliabue G, Berrino F (1996) Int J Cancer 65:309CrossRefGoogle Scholar
  265. 265.
    Tatman D, Mo H (2002) Cancer Lett 175:129CrossRefGoogle Scholar
  266. 266.
    Elson CE (1995) J Nutr 125:1666sGoogle Scholar
  267. 267.
    Wattenberg LW (1983) Cancer Res 43:2488Google Scholar
  268. 268.
    Wattenberg LW (1985) Cancer Res 45:1CrossRefGoogle Scholar
  269. 269.
    Hartman PE, Shankel DM (1990) Environ Mol Mutagen 15:145CrossRefGoogle Scholar
  270. 270.
    Block KI, Gyllenhaal C, Mead MN (2004) Int Cancer Ther 3:128CrossRefGoogle Scholar
  271. 271.
    Mo H, Elson CE (2004) Exp Biol Med 229:567Google Scholar
  272. 272.
    Dorai T, Aggarwal BB (2004) Cancer Lett 215:129CrossRefGoogle Scholar
  273. 273.
    Maddocks W (2002) Int J Aromat 12: 30CrossRefGoogle Scholar
  274. 274.
    Guba R (2000) Toxicity myths essential oils and their carcinogenic potential. In: Essential Oils and Cancer. Proceedings of the 4th Wholistic Aromatherapy Conference, San FranciscoGoogle Scholar
  275. 275.
    Elson CE, Peffley DM, Hentosh P, Mo H (1999) Proc Soc Exp Biol Med 221:294CrossRefGoogle Scholar
  276. 276.
    Elson CE, Yu SG (1994) J Nutr 124:607Google Scholar
  277. 277.
    Matura M, Goossens A, Bordalo O, Garcia-Bravo B, Magnusson K, Wrangsjo K, Karlberg AT (2002) J Am Acad Dermatol 47:709CrossRefGoogle Scholar
  278. 278.
    Flavor and Extract Manufacturers’ Association (1991) D-Limonene monographa. Flavor and Extract Manufacturers’ Association, Washington, p 1Google Scholar
  279. 279.
    Phillips LR, Malspeis L, Supko JG (1995) Drug Metab Dispos 23:676Google Scholar
  280. 280.
    Kaji I, Tatsuta M, Iishi H, Baba M, Inoue A, Kasugai H (2001) Int J Cancer 93:441CrossRefGoogle Scholar
  281. 281.
    Maltzman TH, Hurt LM, Elson CE, Tanner MA, Gould MN (1989) Carcinogenesis 10:781CrossRefGoogle Scholar
  282. 282.
    Lu XG, Zhan LB, Feng BA, Qu MY, Yu LH, Xie JH (2004) World J Gastroenterol 10:2140Google Scholar
  283. 283.
    Koo HN, Hong SH, Kim CY, Ahn JW, Lee YG, Kim JJ, Lyu YS, Kim HM (2002) Pharm Res 45:469CrossRefGoogle Scholar
  284. 284.
    Bardon S, Picard K, Martel P (1998) Nutr Cancer 32:1CrossRefGoogle Scholar
  285. 285.
    Izumi S, Takashima O, Hirata T (1999) Biochem Biophys Comm 259:519CrossRefGoogle Scholar
  286. 286.
    Hardcastle IR, Rowlands MG, Barber AM, Grimshaw RM, Mohan MK, Nutley BP, Jarman M (1999) Biochem Pharmacol 57:801CrossRefGoogle Scholar
  287. 287.
    Kawata S, Hagase T, Yamasaki E, Ishiguro H, Matsuzawa Y (1994) J Cancer 69:1015Google Scholar
  288. 288.
    Crowell PL (1997) Breast Cancer Res Treat 46:191CrossRefGoogle Scholar
  289. 289.
    Gelb MH, Tamanoi F, Yokoyama K, Ghomashci F, Esson K, Gould MM (1995) Cancer Lett 91:168.CrossRefGoogle Scholar
  290. 290.
    Crowell PL, Elegbede JA, Elson CE, Lin S, Baltey HH, Vedejs E, Gould MN (1994) Cancer Chemother Pharmacol 35:31Google Scholar
  291. 291.
    Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN (1991) J Biol Chem 266:17679Google Scholar
  292. 292.
    Crowell PL, Kennan WS, Haag JD, Ahmad S, Vedejs E, Gould MN (1992) Carcinogenesis 13:1261CrossRefGoogle Scholar
  293. 293.
    Crowell PL, Lin S, Vedejes E, Gould MN (1992) Cancer Chemother Pharmacol 31:205CrossRefGoogle Scholar
  294. 294.
    Schulz S, Buhiing F, Ansorge S (1994) Eur J Immunol 24:301Google Scholar
  295. 295.
    Miquel K, Pradines A, Terce F, Selmi S, Favre G (1998) J Biol Chem 273:26179CrossRefGoogle Scholar
  296. 296.
    Gana-Weisz M, Halaschek Wiener J, Jansen B, Elad G, Haklai R, Kloog Y (2002) Clin Cancer Res 8:555Google Scholar
  297. 297.
    Egozi Y, Weisz B, Gana Weisz M, Ben Baruch G, Kloog Y (1999) Int J Cancer 80:911CrossRefGoogle Scholar
  298. 298.
    Haklai R, Weisz MG, Elad G, Paz A, Marciano D, Egozi Y, Ben-Baruch G, Kloog Y (1998) Biochemistry 37:1306CrossRefGoogle Scholar
  299. 299.
    Marciano D, Ben-Baruch G, Marom M, Egozi Y, Haklai R, Kloog Y (1995) J Med Chem 38:1267CrossRefGoogle Scholar
  300. 300.
    Ura H, Obara T, Shudo R, Itho A, Tanno S, Fujii T, Nishino N, Khogo Y (1998) Mol Carcinog 21:93CrossRefGoogle Scholar
  301. 301.
    Haag JD, Gould (1994) Cancer Chemother Pharmacol 34:477Google Scholar
  302. 302.
    Steams V, Coop A, Singh B, Gallagher A, Yamauchi H, Lieberman R, Pennanen M, Trock B, Hayes DF, Ellis MJ (2004) Clin Cancer Res 10:7583CrossRefGoogle Scholar
  303. 303.
    Chow HH, Salazar D, Hakin IA (2002) Cancer Epidemiol Biomarkers Prev 11:1472Google Scholar
  304. 304.
    Vigushin DM, Poon GK, Boddy A, English J, Halbert GW, Pagonis C, Jarman M, Coombes RC (1998) Cancer Chemother Pharmacol 42:11CrossRefGoogle Scholar
  305. 305.
    Azzoli CG, Miller VA, Nig KK, Krug LM, Spriggs DR, Tong WP, Riedel ER, Kris MG (2003) Cancer Chemother Pharmacol 51:493Google Scholar
  306. 306.
    Liu G, Oettel K, Bailey H, Van Ummersen L, Tutsch K, Staab MJ, Horvath D, Alberti D, Arzoomanian R, Rezazadeh H, McGovern J, Robinson E, De Mets D, Wilding G (2003) Invest New Drugs 21:367CrossRefGoogle Scholar
  307. 307.
    Bailey HH, Levy D, Harris LS, Schink JC, Foss F, Beatty P, Wadler S (2002) Gynecol Oncol 85:464CrossRefGoogle Scholar
  308. 308.
    Meadows SM, Mulkerin D, Berlin J, Bailey H, Kolesar J, Warren D, Thomas JP (2002) Int J Gastrointest Cancer 32:125CrossRefGoogle Scholar
  309. 309.
    Murren JR, Pizzorno G, DiStasio SA, McKeon A, Peccerillo K, Gollerkari A, McMurray W, Burtness BA, Rutherford T, Li X, Ho PT, Sartorelli A (2002) Cancer Biol Ther 1:130Google Scholar
  310. 310.
    Hudes GR, Szarka CE, Adams A, Ranganathan S, McCauley RA, Weiner LM, Langer CJ, Litwin S, Yeslow G, Halberr T, Qian M, Gallo JM (2000) Clin Cancer Res 6:307Google Scholar
  311. 311.
    Ripple GH, Gould MN, Arzoomanian RZ, Alberti D, Feierabend C, Pomplun M, Simon K, Binger K, Tutsch KD, Pomplun M, Wahamaki A, Marnocha R, Wilding G, Bailey HH (2000) Clin Cancer Res 6:390Google Scholar
  312. 312.
    Elegbede JA, Flores R, Wang RC (2003) Life Sci 73:2831CrossRefGoogle Scholar
  313. 313.
    Clark SS, Zhong L, Filiault D, Perman S, Ren Z, Gould M, Yang X (2003) Clin Cancer Res 9:4494Google Scholar
  314. 314.
    Sahin MB, Perman SM, Jenkins G, Clark SS (1999) Leukemia 13:1581CrossRefGoogle Scholar
  315. 315.
    Stayrook KR, McKinzie JH, Burke YD, Burke YA, Crowell PL (1997) Carcinogenesis 18:1655CrossRefGoogle Scholar
  316. 316.
    Bardon S, Foussard V, Fournel S, Loubat A (2002) Cancer Lett 181:187CrossRefGoogle Scholar
  317. 317.
    Shi WG, Gould MN (2002) Carcinogenesis 23:131CrossRefGoogle Scholar
  318. 318.
    Ariazi EA, Satomi Y, Ellis MJ, Haag JD, Shi W, Sattler CA, Gould MN (1999) Cancer Res 59:1917Google Scholar
  319. 319.
    Elegbede JA, Flores R, Wang RC (2003) Life Sci 73:2831CrossRefGoogle Scholar
  320. 320.
    Ferri N, Arnaboldi L, Orlandi A, Yokoyama K, Gree R, Granata A, Hachem A, Paoletti R, Gelb MH, Corsini A (2001) Biochem Pharmacol 62:1637CrossRefGoogle Scholar
  321. 321.
    Clark SS, Perman SM, Sahin MB, Jenkins GJ, Elegbede JA (2002) Leukemia 16:213CrossRefGoogle Scholar
  322. 322.
    Reddy BS, Wang CX, Samaha H, Lubert R, Steele VE, Kelloff GJ, Rao CV (1997) Cancer Res 57:420Google Scholar
  323. 323.
    Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL (1995) Cancer Res 55:979Google Scholar
  324. 324.
    Jirte RL, Haag JD, Ariazi EA, Gould MN (1993) Cancer Res 53:3849Google Scholar
  325. 325.
    Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB (2002) Cancer Epidemiol Biomarkers Prev 11:573Google Scholar
  326. 326.
    Stayrook KR, McKinzie JH, Barbhaiya LH, Crowell PL (1998) Anticancer Res 18:823Google Scholar
  327. 327.
    Ren Z, Elson CE, Gould MN (1997) Biochem Pharmacol 54:113CrossRefGoogle Scholar
  328. 328.
    Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, Crowll PL, Crowell DN (1996) Cancer Lett 110:49CrossRefGoogle Scholar
  329. 329.
    Berchtold CM, Chen KS, Miyamoto S, Gould MN (2005) Cancer Res 65:8558CrossRefGoogle Scholar
  330. 330.
    Zheng GQ, Kenney PM, Lam LKT (1992) J Nat Prod 55:999CrossRefGoogle Scholar
  331. 331.
    Miyazawa M, Hisama M (2001) J Agric Food Chem 49:4019CrossRefGoogle Scholar
  332. 332.
    Rompelberg CJM, Verhagen H, van Bladeren PJ (1993) Food Chem Toxicol 31:637CrossRefGoogle Scholar
  333. 333.
    Rompelberg CJM, Stenhuis WH, de Vogel N, van Osenbruggen WA, Schouten A, Verhagen H (1995) Mutat Res 346:69CrossRefGoogle Scholar
  334. 334.
    Rompelberg CJM, Evertz SJCJ, Bruijintjes-Rozier GCDM, van den Heuvel PD, Verhagen H (1996) Food Chem Toxicol 34:33CrossRefGoogle Scholar
  335. 335.
    Rompelberg CJM, Steenwinkel MJ, van Asten JG, van Delft JH, Baan RA, Verhagen H (1996) Mutat Res 369:87CrossRefGoogle Scholar
  336. 336.
    Rompelberg CJM, Vogels JT, de Vogel N, Bruijntjes-Rozier GC, Stenhuis WH, Bogaards JJ, Verhagen H (1996) Human Exp Toxicol 15:129CrossRefGoogle Scholar
  337. 337.
    Yokota H, Hashimoto H, Motoya M, Yuasa A (1988) Biochem Pharmacol 37:799CrossRefGoogle Scholar
  338. 338.
    Newbeerne P, Smith RL, Doull J, Goodman JI, Munro IC, Portoghese PS, Wagner BM, Weil CS, Woods LA, Adams TB, Lucas CD, Ford RA (1999) Food Chem Toxicol 37:787Google Scholar
  339. 339.
    Fujisawa S, Atsumi T, Kadoma Y, Sakagami H (2002) Toxicology 177:39CrossRefGoogle Scholar
  340. 340.
    Nagababu E, Lakshmaiah N (1992) Biochem Pharmacol 43:2393CrossRefGoogle Scholar
  341. 341.
    Udilova N, Jurek D, Marian B, Gille L, Schulte Hermann R, Nohl H (2003) Food Chem Tox 41:1481CrossRefGoogle Scholar
  342. 342.
    Gonzalez MJ (1992) Med Hypotheses 38:106CrossRefGoogle Scholar
  343. 343.
    Yoo CB, Han KT, Cho KS, Ha J, Park HJ, Nam JH, Kil UH, Lee KT (2005) Cancer Lett 225:41CrossRefGoogle Scholar
  344. 344.
    Francis AR, Shetty TK, Bhattacharya RK (1989) Cancer Lett 45:177CrossRefGoogle Scholar
  345. 345.
    Abraham SK (2001) Food Chem Toxicol 39:493CrossRefGoogle Scholar
  346. 346.
    Wattenberg LW, Spamins VL, Barany G (1989) Cancer Res 48:2688Google Scholar
  347. 347.
    Raphael TJ, Kuttan G (2003) J Exp Clin Cancer Res 22:419Google Scholar
  348. 348.
    Shoff SM, Grummer M, Yatvin MB, Elson CE (1991) Cancer Res 51:37Google Scholar
  349. 349.
    Yu SG, Hildebrandt LA, Elson CE (1995) J Nutr 125:2763Google Scholar
  350. 350.
    Carnesecchi S, Schneider Y, Ceraline J, Duranton B, Gosse F, Seiler N, Raul F (2001) J Pharmacol Exp Ther 298:197Google Scholar
  351. 351.
    Carnesecchi S, Bradaia A, Fischer B, Coelho D, Scholler-Guinard M, Gosse F, Raul F (2002) J Pharmacol Exp Ther 303:711CrossRefGoogle Scholar
  352. 352.
    Carnesecchi S, Goncalves RB, Bradaia A, Zeisel M., Gosse F, Poupon MF, Raul F (2004) Cancer Lett 215:53CrossRefGoogle Scholar
  353. 353.
    Duncan RE, Lau D, ElSohemy A, Archer MC (2004) Biochem Pharmacol 68:1739CrossRefGoogle Scholar
  354. 354.
    Mc Anally JA, Jung M, Mo H (2003) Cancer Lett 202:181CrossRefGoogle Scholar
  355. 355.
    Clegg RJ, Middieton B, Bell D, White DA (1982) J Biol Chem 257:2294Google Scholar
  356. 356.
    Budavari S (1996) The Merk Index, 12th edn. Merck Research Laboratories Division of Merck & Co, Whitehouse Station, p 208Google Scholar
  357. 357.
    Cavalieri E, Mariotto S, Fabrizi C, Carcereri de Prati A, Gottardo R, Leone S, Berra LV, Lauro GM, Ciampa AR, Suzuki H (2004) Res Commun 315:589Google Scholar
  358. 358.
    Hernandez Ceruelos A, Madrigal Bujaidar E, de la Cruz C (2002) Toxicol Lett 135:103CrossRefGoogle Scholar
  359. 359.
    Surth YJ (2003) Nat Rev Cancer 3:768CrossRefGoogle Scholar
  360. 360.
    Bharti AC, Aggarwal BB (2002) Biochem Pharmacol 64:883CrossRefGoogle Scholar
  361. 361.
    Kim JH, Lee HJ, Kim GS, Choi DH, Lee SS, Kang JK, Chae C, Paik NW, Cho MH (2004) Cancer Lett 213:139CrossRefGoogle Scholar
  362. 362.
    Zeytinoglu H, Incesu Z, Baser KHC (2003) Phytomedicine 10:292CrossRefGoogle Scholar
  363. 363.
    Russin WA, Hoesly JD, Elson CE, Tanner MA, Gould MN (1989) Carcinogenesis 10:2161CrossRefGoogle Scholar
  364. 364.
    Ka H, Park HJ, Jung HJ, Choi JW, Cho KS, Ha J, Lee KT (2003) Cancer Lett 196:143CrossRefGoogle Scholar
  365. 365.
    Wright MM, Henneberry AL, Lagace TA, Ridgway ND, McMaster CR (2001) J Biol Chem 276:25254CrossRefGoogle Scholar
  366. 366.
    Imai T, Yasuhara K, Tamura T, Takizawa T, Ueda, Hirose M (2002) Cancer Lett 175:9CrossRefGoogle Scholar
  367. 367.
    Idaomar M, El Hamss R, Bakkali F, Mezzoug N, Zhiri A, Baudoux D, Munoz Serrano A, Liemans V, Alonso-Moraga A (2002) Mutat Res 512:61Google Scholar
  368. 368.
    Letizia CS, Cocchiara J, Lalko J, Api AM (2003) Food Chem Toxicol 41:43Google Scholar
  369. 369.
    Sasaki YF, Imanishi H, Phta T, Shirasu Y (1989) Mutat Res 226:103CrossRefGoogle Scholar
  370. 370.
    Bickers D, Greim H, Hanifin JH, Rogers AE, Saurat JH, Sipes LG, Smith RL, Tagami H (2003) Food Chem Toxicol 41:919CrossRefGoogle Scholar
  371. 371.
    Van Duuren BL, Blazej T, Goldschmidt BM, Katz C, Melchionne S, Sivak A (1971) J Natl Cancer Inst 46:1039Google Scholar
  372. 372.
    De Vincenzi M, Silano M, Maialetti F, Scazzocchio B (2000) Fitoterapia 71:725CrossRefGoogle Scholar
  373. 373.
    Burkey JL, Sauer JM, McQueen CA, Sipes IG (2000) Mutat Res 453:25Google Scholar
  374. 374.
    Abdo KM, Cunningham ML, Snell ML, Herbert RA, Travlos GS, Eldridge SR, Bucher JR (2001) Food Chem Toxicol 39:303CrossRefGoogle Scholar
  375. 375.
    Smith RL, Adams TB, Doull J, Feron VJ, Goodman JI, Marnett LJ, Portoghese PS, Waddell WJ, Wagner BM, Rogers AE, Caldwell J, Sipes IG (2004) Food Chem Toxicol 40:851CrossRefGoogle Scholar
  376. 376.
    Burguiere L, Marion-Poll F, Cork A (2001) J Insect Physiol 47:509CrossRefGoogle Scholar
  377. 377.
    Borg-Karlson AK, Unelius CR, Valterova I and Nilsson LA (1996) Phytochemistry 41:1477CrossRefGoogle Scholar
  378. 378.
    Bengtsson M, Backman AC, Liblikas I, Ramirez MI, Borg-Karlson AK, Ansebo L, Anderson P, Lofqvist J, Witzgall P (2001) J Agric Food Chem 49:3736CrossRefGoogle Scholar
  379. 379.
    Pureswaran DS, Gries R, Borden JH (2004) Chemoecology 14:59CrossRefGoogle Scholar
  380. 380.
    Allison JD, Borden JH, Seybold SJ (2004) Chemoecology 14:123CrossRefGoogle Scholar
  381. 381.
    Gadi V, Reddy P, Guerrero A (2004) Trends Plant Sci 9:253CrossRefGoogle Scholar
  382. 382.
    Bichao H, Borg-Karlson AK, Araujo J, Mustaparta H (2003) J Comp Physiol A 189:203Google Scholar
  383. 383.
    Stranden M, Rostelien T, Liblikas I, Almaas TJ, Borg-Karlson AK, Mustaparta H (2003) Chemoecology 13:143CrossRefGoogle Scholar
  384. 384.
    Rostelien T, Borg-Karlson AK, Faldt J, Jacobsson U, Mustaparta H (2000) Chem Senses 25:141CrossRefGoogle Scholar
  385. 385.
    Mozuraitis R, Stranden M, Ramirez MI, Borg-Karlson AK, Mustaparta H (2002) Chem Senses 27:505CrossRefGoogle Scholar
  386. 386.
    Reisenman CE, Christensen TA, Francke W, Hildebrand JG (2004) J Neurosci 24:2602CrossRefGoogle Scholar
  387. 387.
    Allison JD, Morewood WD, Borden JH, Hein KE, Wilson IM (2003) Environ Entomol 32:23CrossRefGoogle Scholar
  388. 388.
    Mühlbauer RC, Lozano A, Palacio S, Reinli A, Felix R (2003) Bone 32:372CrossRefGoogle Scholar
  389. 389.
    Yamaguchi K, Shinohara C, Kojima S, Sodeoka M, Tsuji T (1999) Biosci Biotechnol Biochem 63:731CrossRefGoogle Scholar
  390. 390.
    Perry NSL, Bollen C, Perry EK, Ballard C (2003) Pharmacol Biochem Behav 75:651CrossRefGoogle Scholar
  391. 391.
    Wei Chen S, Min L, Jing Li W, Xi Kong W, Fang Li J, Jing Zhang Y (2004) Pharmacol Biochem Behav 79:377CrossRefGoogle Scholar
  392. 392.
    Broughan C (2002) Int J Aromather 12:92CrossRefGoogle Scholar
  393. 393.
    Svoboda KP, Karavia AN, McFarlane V (2002) Int J Aromather 12:67Google Scholar
  394. 394.
    Alexander M (2002) Int J Aromather 12:49CrossRefGoogle Scholar
  395. 395.
    Standen MD, Myers SP (2004) Int J Aromather 14:150CrossRefGoogle Scholar
  396. 396.
    Vale TG, Matos FJA, de Lima TCM, Viana GSB (1999) J Ethnopharmacol 167:127CrossRefGoogle Scholar
  397. 397.
    Aloisi AM, Ceccarelli I, Masi F, Scaramuzzino A (2002) Behav Brain Res 136:127CrossRefGoogle Scholar
  398. 398.
    Ceccarelli I, Lariviere WR, Fiorenzani P, Sacerdote P, Aloisi AM (2004) Brain Res 1001:78CrossRefGoogle Scholar
  399. 399.
    Spinella M (2001) Epilepsy Behav 2:524CrossRefGoogle Scholar
  400. 399.
    Orafidiya LO, Agbani EO, Oyedele AO, Babalola OO, Onayemi O, Aiyedun FF (2004) Int J Aromather 14:15CrossRefGoogle Scholar
  401. 400.
    Rosa MSS, Mendonca Filho RR, Bizzo HR, Rodrigues IA, Soares RMA, Souto Padron T, Alviano CS, Lopes AHCS (2003) Antimicrob Agents Chemother 1895Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Adolfina R. Koroch
    • 1
  • H. Rodolfo Juliani
    • 1
  • Julio A. Zygadlo
    • 2
  1. 1.New Use Agriculture and Natural Plant Products Program, Cook CollegeRutgers UniversityNew BrunswickUSA
  2. 2.Instituto Multidisciplinario de Biologia Vegetal (IMBIV-CONICET)National University of CórdobaArgentina

Personalised recommendations