Geometrical and Morphological Analysis of Vascular Branches from Fundus Retinal Images
A semi-automatic method to measure and quantify geometrical and topological properties of complete vascular trees in fundus images is described. The method is validated by comparing automatic vs. manual measurements in 17 individual bifurcations. We also compared automatic analyses of complete vascular trees from 4 pairs of red-free and fluorescein images. Preliminary results comparing 10 hypertensive and 10 normotensive subjects show changes in geometrical properties similar to those reported in previous studies. Several topological indices show differences in the arterial, but not venous, trees in hypertensive subjects. This suggests that a combination of geometrical and topological measurements of the whole vascular network may provide more sensitive indicators of morphological changes due to diseases.
KeywordsBifurcation Point Topological Index Parent Vessel Fundus Image Hypertensive Group
- 3.King, L.A., Stanton, A.V., Sever, P.S., Thom, S., Hughes, A.D.: Arteriolar length-diameter (l:d) ratio: A geometric parameter of the retinal vasculature diagnostic of hypertension. J. Hum. Hypertens. 10, 417–418 (1996)Google Scholar
- 4.MacDonald, N.: Trees and Networks in Biological Models. John Wiley & Sons, New York (1983)Google Scholar
- 5.Martínez-Pérez, M.E., Hughes, A.D., Stanton, A.V., Thom, S.A., Bharath, A.A., Parker, K.H.: Retinal blood vessel segmentation by means of scale-space analysis and region growing. In: Taylor, C., Colchester, A. (eds.) MICCAI 1999. LNCS, vol. 1679, pp. 90–97. Springer, Heidelberg (1999)Google Scholar
- 9.Stanton, A.V., Wasan, B., Cerutti, A., Ford, S., Marsh, R., Sever, P.P., Thom, S.A., Hughes, A.D.: Vascular network changes in the retina with age and hypertension. J. Hypertens. 13, 1724–1728 (1995)Google Scholar
- 10.Struijker, H.A.J., le Noble, J.L.M., Messing, M.W.J., Huijberts, M.S.P., le Noble, F.A.C., van Essen, H.: The microcirculation and hypertension. J. Hypertens. 10(7), S147–S156 (1992)Google Scholar