Overview of protein serine/threonine phosphatases
Protein phosphatases that cleave phosphate from phosphorylated serine and threonine in proteins are crucial for the regulation of most cellular processes. Three structurally distinct families of protein serine/threonine phosphatases (PPP, PPM, and FCP) are described and the phylogenetic relationships in the PPP and PPM families of Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae are examined. An overview of the functions of the PPP, PPM, and FCP members gained from recent genetic analyses is presented.
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