Image Registration for Interventional MRI Guided Procedures: Interpolation Methods, Similarity Measurements, and Applications to the Prostate

  • Baowei Fei
  • Zhenghong Lee
  • Jeffery L. Duerk
  • David L. Wilson
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2717)


Nuclear medicine can detect and localize tumor in the prostate not reliably seen in MR. We are investigating methods to combine the advantages of SPECT with interventional MRI (iMRI) guided radiofrequency thermal ablation of the prostate. Our approach is to first register the low-resolution functional images with a high resolution MR volume. Then, by combining the high-resolution MR image with live-time iMRI acquisitions, we can, in turn, include the functional data and high-resolution anatomic information into the iMRI system for improved tumor targeting. In this study, we investigated registration methods for combining noisy, thick iMRI image slices with high-resolution MR volumes. We compared three similarity measures, i.e., normalized mutual information, mutual information, and correlation coefficient; and three interpolation methods, i.e., re-normalized sinc, tri-linear, and nearest neighbor. Registration experiments showed that transverse slice images covering the prostate work best with a registration error of ≈ 0.5 mm as compared to our volume-to-volume registration that was previously shown to be quite accurate for these image pairs.


Mutual Information Interpolation Method Image Registration Normalize Mutual Information Registration Error 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Baowei Fei
    • 1
  • Zhenghong Lee
    • 1
    • 2
  • Jeffery L. Duerk
    • 1
    • 2
  • David L. Wilson
    • 1
    • 2
  1. 1.Department of Biomedical EngineeringCase Western Reserve UniversityClevelandUSA
  2. 2.Department of RadiologyUniversity Hospitals of ClevelandClevelandUSA

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