Molecular genetics of genotoxic stress signalling in plants
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Cells are under constant threat by endogenous and exogenous factors affecting DNA integrity. In response, complex signalling networks are activated and appropriate countermeasures are taken. Although plants are inevitably exposed to diverse DNA damaging agents (genotoxins) due to their sessile life-style and dependence on sunlight for photosynthesis, plant signalling components activated by confronting genotoxic stress are largely unknown. However, recent genetic and biochemical analyses have advanced our understanding of genotoxic stress signalling. In particular, as deduced from mammalian model systems, players of both the postulated “nuclear”- and “non-nuclear”-target-mediated signal transduction chains were identified. Importantly, components of both pathways are crucial for plant tolerance to genotoxic stress.
KeywordsNucleotide Excision Repair Ataxia Telangiectasia Genotoxic Stress Genotoxic Agent Nijmegen Breakage Syndrome
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