The Regulation of Differentiation in Murine Virus-Induced Erythroleukemic Cells

  • Ch. Friend
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 11)

Abstract

Continuous lines of erythroleukemia cells, which originate from the spleens of mice with Friend virus-induced leukemia, provide a convenient experimental system in which the molecular control of erythrodifferentiation can be examined in some detail (Friend et al. 1966; Ikawa and Sugano 1966; Ostertag et al. 1972; Freedman and Lilly 1975). The cultures contain cells at various stages of differentiation. The majority are large, primitive erythroid cells with prominent nucleoli, but a few more mature cells recognizable as normoblasts are present. We had developed these lines with the idea of studying leukemia as a disease resulting from a block in maturation, and had hoped to find means of stimulating the cells to differentiate. To a certain extent, we achieved this goal.

Keywords

Globin Gene Erythroid Differentiation Erythroleukemia Cell Heme Synthesis Globin Chain 
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References

  1. Adesnik M., Smitkin H.: Induction of erythroid differentiation in Friend leukemia cells by bromodeoxyuridine. J. Cell Physiol. 95, 307–318 (1978).PubMedCrossRefGoogle Scholar
  2. Alter B.P., Goff S.C.: Globin synthesis in mouse erythroleukemia cells in vitro: a switch in beta chains due to inducing agent. Blood 50, 867–876 (1977).PubMedGoogle Scholar
  3. Arndt-Jovin D.J., Ostertag W., Eisen H., Limek F., Jovin T.M.: Studies of cellular differentiation by automated cell separation. Two model systems: Friend virus-transformed cells and hydra attenuata. J. Histochem. Cytochem. 24, 332–347 (1976).Google Scholar
  4. Aviv H., Voloch Z., Xastos R., Levy S.: Biosynthesis and stability of globin mRNA in cultured erythroleukemic Friend cells. Cell 8, 495–503 (1976).PubMedCrossRefGoogle Scholar
  5. Baird W.M., Sedgwick J.A., Boutwell R.K.: Effects of phorbol and 4 diesters of phorbol on the incorporation of tritiated precursors into DNA, RNA and protein in mouse epidermis. Cancer Res. 31, 1434–1439 (1971).PubMedGoogle Scholar
  6. Bernstein A., Boyd A.S., Crichley V., Lamb V.: Induction and inhibition of Friend leukemic cell differentiation: the role of membrane-active compounds. In: Biogenesis and Turnover of Membrane Macromolecules (ed. J.S. Cook), pp. 145–159. New York: Raven Press 1976a.Google Scholar
  7. Bernstein A., Hunt D.M., Crichley V., Mak T.W.: Induction by ouabain of hemoglobin synthesis in cultured Friend erythroleukemic cells. Cell 9, 375–381 (1976b).PubMedCrossRefGoogle Scholar
  8. Bick M.D., Cullen B.R.: Bromodeoxyuridine inhibition of Friend leukemia cell induction by butyric acid: Time course of inhibition, reversal and effect of other base analogs. Somat. Cell Genet. 2, 545–558 (1976).CrossRefGoogle Scholar
  9. Boyer S.H., Wuu K.D., Noyes A.N., Young R., Scher W., Friend C., Preisler H.D., Bank A.: Hemoglobin biosynthesis in murine virus-induced leukemic cells in vitro: structure and amounts of globin chains produced. Blood 40, 823–835 (1972).PubMedGoogle Scholar
  10. Cohen R., Pacifici M., Rubenstein N., Biehl J., Holtzer H.: Effect of a tumor promoter on myogenesis. Nature (London) 266, 538–540 (1977).CrossRefGoogle Scholar
  11. Dabney B.J., Beaudet A.L.: Increase in globin chains and globin mRNA in erythroleukemia cells in response to hemin. Arch. Biochem. Biophys. 179, 106–112 (1977).PubMedCrossRefGoogle Scholar
  12. Diamond L., O’Brien T.G., Rovera G.: Inhibition of adipose conversion of 3T3 fibroblasts by tumor promoters. Nature (London) 269, 247–249 (1977).CrossRefGoogle Scholar
  13. Driedger P.E., Blumberg P.M.: The effect of phorbol diesters an chicken embryo fibroblasts. Cancer Res. 37, 3257–3265 (1977).PubMedGoogle Scholar
  14. Ebert P.S., Wars I., Buell D.N.: Erythroid differentiation in cultured Friend leukemia cells treated with metabolic inhibitors. Cancer Res. 36, 1809–1813 (1976).PubMedGoogle Scholar
  15. Edelman G.M.: Surface modulation in cell recognition and cell growth. Science 192, 218–226 (1976).PubMedCrossRefGoogle Scholar
  16. Eisen H., Bach R., Emery R.: Induction of spectrin in erythroleukemic cells transformed by Friend virus. Proc. Natl. Acad. Sci. USA 74, 3898–3902 (1977).PubMedCrossRefGoogle Scholar
  17. Fico R.M., Chen T.K., Canellakis E.S.: Bifunctional intercalators: relationship of antitumor activity of diacridine to the cell membrane. Science 198, 53–56 (1977).PubMedCrossRefGoogle Scholar
  18. Freedman H., Lilly F.: Properties of cell lines derived from tumors induced by Friend virus in Balb-C and Balb-C-H-2b mice. J. Exp. Med. 142, 212–223 (1975).PubMedCrossRefGoogle Scholar
  19. Friend C.: The phenomenon of differentiation in murine erythroleukemic cells. In: The Harvey Lectures. Series 72, pp. 253–282. New York-London: Academic Press 1979.Google Scholar
  20. Friend C., Freedman H.A.: Effects and possible mechanism of action of dimethyl sulfoxide (DMSO) on Friend cell differentiation. Biochem. Pharmacol. 27, 1309–1314 (1978).PubMedCrossRefGoogle Scholar
  21. Friend C., Patuleia M.C., de Harven E.: Erythrocytic maturation in vitro of murine (Friend) virus-induced leukemic cells. NCI Monogr. 22, 505–522 (1966).Google Scholar
  22. Friend C., Scher W., Holland J.G., Sato T.: Hemoglobin synthesis in murine virus-induced leukemic cells in vitro. Proc. Natl. Acad. Sci. USA 68, 378–382 (1971).PubMedGoogle Scholar
  23. Golde D.W., Bersch N., Cline M.J.: Potentiation of erythropoiesis in vitro by dexamethasone. J. Clin. Invest. 57, 57–62 (1976a).PubMedCrossRefGoogle Scholar
  24. Golde D.W., Bersch N., Quan S.G., Cline M.J.: Inhibition of murine granulopoiesis in vitro by dexamethasone. Am. J. Hematol. 1, 369–373 (1976b).PubMedCrossRefGoogle Scholar
  25. Gusella J.F., Housman D.: Induction of erythroid differentiation in vitro by purines and purine analogues. Cell 8, 263–269 (1976).PubMedCrossRefGoogle Scholar
  26. Gusella J., Geller R., Clarke B., Weeks V., Housman D.: Commitment to erythroid differentiation by Friend erythroleukemia cells: a stochastic analysis. Cell 9, 221–229 (1976).PubMedCrossRefGoogle Scholar
  27. Harrison P.R.: Analysis of erythropoiesis at the molecular level. Nature (London) 262, 353–365 (1976).CrossRefGoogle Scholar
  28. Hendry L.B., Witham F.H., Chapman O.L.: Gene regulation: the involvement of sterochemical recognition in DNA small molecule interaction. Perspect. Biol. Med. 21, 120–130 (1977).PubMedGoogle Scholar
  29. Himes R.H., Burton P.R., Kersey R.N., Pierson G.B.: Brain tubulin polymerization in the absence of “microtubule-associated proteins”. Proc. Natl. Acad. Sci. USA 73, 4397–4399 (1976).PubMedCrossRefGoogle Scholar
  30. Huggins C., Yang N.C.: Induction and extinction of mammary cancer. A striking effect of hydrocarbons permits analysis of mechanisms of causes and cure of breast cancer. Science 173, 257–260 (1962).Google Scholar
  31. Ikawa Y., Sugano H.: An ascites tumor derived from early splenic lesion of Friend’s disease. Gann 57, 641–643 (1966).PubMedGoogle Scholar
  32. Ikawa Y., Furusawa M., Sugano H.: Erythrocyte membrane-specific antigens in Friend virus-induced leukemia cells. In: Unifying Concepts of Leukemia (eds. R.M. Dutcher, L. Chieco-Bianchi), pp. 955–967. Basel: Karger 1973.Google Scholar
  33. Ikawa Y., Inoue Y., Aida M., Kameji C., Shibeta D., Sugano H.: Phenotypic variants of differentiation-inducible Friend leukemia lines: isolation and correlation between inducibility and virus release. In: Comparative Leukemia Research (eds. J. Clemmesen, D.S. Yohn), pp. 37–47. Basel: Karger 1976.Google Scholar
  34. Ishii D., Maniatis G.M.: Hemin induces neuroblastoma differentiation. Nature (London) 274, 372–343 (1978).CrossRefGoogle Scholar
  35. Kabat D., Sherton C.C., Evans L.M., Bigley R., Koler R.D.: Synthesis of erythrocyte-specific proteins in cultured Friend leukemic cells. Cell 5, 331–338 (1975).PubMedCrossRefGoogle Scholar
  36. Kimhi Y., Palfrey C., Spector I., Barak Y., Littauer U.Z.: Maturation of neuroblastoma cells in the presence of DMSO. Proc. Natl. Acad. Sci. USA 73, 462–466 (1976).PubMedCrossRefGoogle Scholar
  37. Kluge N., Ostertag W., Sugiyama T., Arndt-Jovin D., Steinheider G., Furusawa M., Dube S.K.: Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene. Proc. Natl. Acad. Sci. USA 73, 1237–1240 (1976).PubMedCrossRefGoogle Scholar
  38. Lacour F., Harel L., Friend C., Huynh T., Holland J.G.: Induction of differentiation of murine erythroleukemia cells by aminonucleoside of puromycin and its inhibition by purines and purine derivatives. Proc. Natl. Acad. Sci. USA 77, 2740–2742 (1980).PubMedCrossRefGoogle Scholar
  39. Leder A., Leder P.: Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemia cells. Cell 5, 319–323 (1975).PubMedCrossRefGoogle Scholar
  40. Lo S.-C, Aft R., Ross J., Mueller G.C.: Control of globin gene expression by steroid hormones in differentiating Friend leukemia cells. Cell 15, 447–453 (1978).PubMedCrossRefGoogle Scholar
  41. Loritz F., Bernstein A., Miller R.G.: Early and late volume changes during erythroid differentiation of cultured Friend leukemic cells. J. Cell Physiol. 94, 275–286 (1977).Google Scholar
  42. Lowe M.E., Pacifici M., Holtzer H.: Effects of phorbol-12-myristate-B-acetate on the phenotypic program of cultured chondroblasts and fibroblasts. Cancer Res. 38, 2350–2356 (1978).PubMedGoogle Scholar
  43. Lyman G.H., Preisler H.D., Papahadjopoulos D.: Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation. Nature (London) 262, 360–363 (1976).CrossRefGoogle Scholar
  44. Malpoix P.: Haemoglobin synthesis induced by Nu-methyl-2-pyrrolidinone and dimethyl sulfoxide in permanent cell lines derived from normal mouse foetal liver. Arch. Int. Physiol. Biochim. 84, 1090–1091 (1976).PubMedGoogle Scholar
  45. Miao R.M., Fieldsteel A.H., Fodge D.W.: Opposing effects of tumour promoters on erythroid differentiation. Nature (London) 274, 271–272 (1978).CrossRefGoogle Scholar
  46. Miura Y., Wilt F.H.: The effects of 5-bromodeoxyuridine on yolk sac erythropoiesis in the chick embryo. J. Cell Biol. 48, 523–531 (1971).PubMedCrossRefGoogle Scholar
  47. Miura Y., Terasawa T., Sawatani S.: Dimethyl sulfoxide (DMSO) stimulates heme synthesis in quail embryonic yolk sac cells. Exp. Cell Res. 99, 197–200 (1976).PubMedCrossRefGoogle Scholar
  48. Mueller G.C., Kensler T.W., Kajiwara K.: Mechanism of DNA and chromatin replication: possible targets of cocarcinogenesis. In: Carcinogenesis, Vol. 2, Mechanisms of Tumor Promotion and Cocarcinogenesis (eds. T.J. Slaga, A. Sivak, R.K. Boutwell), pp. 79–90. New York: Raven Press 1978.Google Scholar
  49. Nudel U., Salmon J.E., Terada M., Bank A., Rifkind R.A., Marks P.A.: Differential effects of chemical inducers on expression of β globin genes in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 74, 1100–1104 (1977).PubMedCrossRefGoogle Scholar
  50. O’Brien T.G., Diamond L.: Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor promoting phorbol diesters. Cancer Res. 37, 3895–3900 (1977).PubMedGoogle Scholar
  51. Orkin S.H., Harosi F.I., Leder P.: Differentiation in erythroleukemic cells and their somatic hybrids. Proc. Natl. Acad. Sci. USA 72, 98–102 (1975a).PubMedCrossRefGoogle Scholar
  52. Orkin S.H., Swan D., Leder P.: Differential expression of alpha and beta globin genes during differentiation of cultured erythroleukemic cells. J. Biol. Chem. 250, 8753–8760 (1975b).PubMedGoogle Scholar
  53. Ostertag W., Melderis H., Steinheider G., Kluge N., Dube S.: Synthesis of mouse haemoglobin and globin mRNA in leukemic cell cultures. Nature New Biol. 239, 231–232 (1972).PubMedGoogle Scholar
  54. Palfrey C., Kimhi V., Littauer U.Z., Reuben R.C., Marks P.A.: Induction of differentiation in mouse neuroblastoma cells by hexamethylene bisacetamide. Biochem. Biophys. Res. Commun. 76, 937–942 (1977).PubMedCrossRefGoogle Scholar
  55. Papahadjopoulos D., Jacobson K., Poste G., Shepherd C.: Effect of local anesthetics on membrane properties. I. Changes in the fluidity of phospholipid bilayers. Biochem. Biophys. Acta 394, 504–519 (1975).Google Scholar
  56. Peterson A.R., Mondal S., Brankow D.W., Thon W., Heidelberger C.: Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts. Cancer Res. 37, 3223–3227 (1977).PubMedGoogle Scholar
  57. Prasad K.N., Mandel B., Kumar S.: Human neuroblastoma cell culture: Effect of 5-bromodeoxyuridine on morphological differentiation and levels of neural enzymes. Proc. Soc. Exp. Biol. Med. 144, 38–42 (1973).PubMedGoogle Scholar
  58. Preisler H.D., Housman D., Scher W., Friend C.: Effects of 5-bromo-2′-deoxyuridine on the production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells. Proc. Natl. Acad. Sci. USA 70, 2956–2959 (1973).PubMedCrossRefGoogle Scholar
  59. Rabson A.S., Stern R., Tralka T.S., Costa J., Wilczek J.: Hexamethylene bisacetamide induces morphologic changes and increased synthesis of precollagen in cell line from glioblastoma multiform. Proc. Natl. Acad. Sci. USA 74, 5060–5064 (1977).PubMedCrossRefGoogle Scholar
  60. Reem G.H., Friend C.: Purine metabolism in murine virus-induced erythroleukemic cells during differentiation in vitro. Proc. Natl. Acad. Sci. USA 72, 1630–1634 (1975).PubMedCrossRefGoogle Scholar
  61. Reem G.H., Friend C: Purine and phosphoribosylpyrophosphate synthesis in differentiating murine virus-induced erythroleukemic cells in vitro. J. Cell Physiol. 88, 193–196 (1976).PubMedCrossRefGoogle Scholar
  62. Reuben R.C., Wife R.L., Breslow R., Rifkind R.A., Marks P.A.: A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 73, 862–866 (1976).PubMedCrossRefGoogle Scholar
  63. Reuben R.C., Khanna P., Gazitt Y., Breslow R., Rifkind R.A., Marks P.A.: Inducers of erythroleukemic differentiation. J. Biol. Chem. 253, 4214–4218 (1978).PubMedGoogle Scholar
  64. Rohrschneider L.R., Boutwell R.K.: The early stimulation of phospholipid metabolism by 12-0-tetradecanoyl-phorbol-13-acetate and its specificity for tumor promotion. Cancer Res. 33, 1945–1952 (1973).PubMedGoogle Scholar
  65. Ross J., Sautner D.: Induction of globin mRNA accumulation by hemin in cultured erythroleukemic cells. Cell 8, 512–520 (1976).CrossRefGoogle Scholar
  66. Ross J., Ikawa Y., Leder P.: Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. Proc. Natl. Acad. Sci. USA 69, 3520–3623 (1972).CrossRefGoogle Scholar
  67. Rossi G.B., Dolei A., Cioe L., Benedetto A., Malarese G.P., Belardelli F.: Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemia cells treated with interferon. Proc. Natl. Acad. Sci. USA 74, 2036–2040 (1977).PubMedCrossRefGoogle Scholar
  68. Rovera G., O’Brien T., Diamond L.: Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemic cells in culture. Proc. Natl. Acad. Sci. USA 74, 2894–2898 (1977).PubMedCrossRefGoogle Scholar
  69. Rovera G., Aden D., Surrey S.: Allylisopropylacetamide restricts expression of beta minor globin gene in Friend cells. Nature (London) 272, 172–175 (1978).CrossRefGoogle Scholar
  70. Sachs L.: Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. Nature (London) 274, 535–539 (1978).CrossRefGoogle Scholar
  71. Sato T., de Harven E., Friend C.: Ultrastructural changes in Friend erythroleukemia cells treated with DMSO. Cancer Res. 31, 1402–1407 (1971).PubMedGoogle Scholar
  72. Scher W., Friend C.: Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells. Cancer Res. 38, 841–849 (1978).PubMedGoogle Scholar
  73. Scher W., Preisler H.D., Friend C.: Hemoglobin synthesis in murine virus-induced leukemic cells in vitro. III. Effects of 5-bromo-2′-deoxyuridine, dimethylformamide and dimethyl sulfoxide. J. cell Physiol. 81, 63–70 (1973).PubMedCrossRefGoogle Scholar
  74. Scher W., Tsuei D., Sassa S., Price P., Gabelman N., Friend C.: Inhibition of DMSO-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids. Proc. Natl. Acad. Sci. USA 75, 3851–3855 (1978).PubMedCrossRefGoogle Scholar
  75. Schubert D., Jacob F.: 5-Bromodeoxyuridine-induced differentiation of a neuroblastoma. Proc. Natl. Acad. Sci. USA 67, 247–254 (1970).PubMedCrossRefGoogle Scholar
  76. Seeman P.: The membrane action of anesthetics and tranquilizers. Pharmacol. Rev. 24, 583–655 (1972).PubMedGoogle Scholar
  77. Sherton C.C., Evans L.H., Polonoff E., Kabat D.: Relationship of Friend murine leukemia virus production to growth and hemoglobin synthesis in cultured erythroleukemia cells. J. Virol. 19, 118–125 (1976).PubMedGoogle Scholar
  78. Silagi S., Bruce S.A.: Suppression of malignancy and differentiation in melanotic melanoma cells. Proc. Natl. Acad. Sci. USA 66, 72–78 (1970).PubMedCrossRefGoogle Scholar
  79. Stockdale F., Okazaki K., Nameroff M., Holtzer H.: 5-Bromodeoxyuridine. Effect on myogenesis in vitro. Science 146, 533–535 (1964).Google Scholar
  80. Tanaka M., Levy J., Terada M., Breslow R., Rifkind R.A., Marks P.A.: Induction of erythroid differentiation in murine virus infected erythroleukemia cells by highly polar compounds. Proc. Natl. Acad. Sci. USA 72, 1003–1006 (1975).PubMedCrossRefGoogle Scholar
  81. Terada M., Epner E., Nudel U., Salmon J., Fibach E., Rifkind R.A., Marks P.A.: Induction of murine erythroleukemia differentiation by actinomycin D. Proc. Natl. Acad. Sci. USA 75, 2795–2799 (1978a).PubMedCrossRefGoogle Scholar
  82. Terada M., Nudel U., Fibach E., Rifkind R.A., Marks P.A.: Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells. Cancer Res. 38, 835–840 (1978b).PubMedGoogle Scholar
  83. Tralka T.S., Rabson A.S.: Cilia formation in cultures of human lung cancer cells treated with dimethyl sulfoxide. J. Natl. Cancer Inst. 57, 1383–1388 (1976).PubMedGoogle Scholar
  84. Tsuei D., Haubenstock H., Friend C.: Virus production and erythroid differentiation in Friend erythroleukemia cells. In Vitro 13, 148 (1977).Google Scholar
  85. Yamasaki H., Fibach E., Weinstein L.B., Nudel U., Rifkind R.A., Marks P.A.: Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture. Proc. Natl. Acad. Sci. USA 74, 3451–3455 (1977).PubMedCrossRefGoogle Scholar
  86. Yuspa S.H., Lichti U., Ben T., Patterson E., Hennings H., Slaga T.J., Colburn N., Kelsey W.: Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell culture. Nature (London) 262, 402–404 (1976).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • Ch. Friend
    • 1
  1. 1.The Mollie B. Roth LaboratoryThe Mount Sinai School of Medicine of the City University of New YorkNew YorkUSA

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