Skip to main content

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lohmann CP et al (1992) Corneal light scattering after excimer laser photorefractive keratectomy: the objective measurements of haze. Refract Corneal Surg 8:114–21

    PubMed  CAS  Google Scholar 

  2. Hayashida Y et al (2006) Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze. Invest Ophthalmol Vis Sci 47:552–557

    Article  PubMed  Google Scholar 

  3. Hersh PS, Abbassi R(1999) Surgically induced astigmatism after photorefractive keratectomy and laser in situ keratomileusis. Summit PRK-LASIK Study Group. J Cataract Refract Surg 25:389–398

    Article  PubMed  CAS  Google Scholar 

  4. El-Maghraby A et al (1999) Randomized bilateral comparison of excimer laser in situ keratomileusis and photorefractive keratectomy for 2.50 to 8.00 diopters of myopia. Ophthalmology 106:447–457

    Article  PubMed  CAS  Google Scholar 

  5. Fantes FE et al (1990) Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys. Arch Ophthalmol 108:665–675

    PubMed  CAS  Google Scholar 

  6. Netto MV et al (2005) Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 24:509–522

    Article  PubMed  Google Scholar 

  7. Stephenson CG et al (1998) Photorefractive keratectomy: a 6-year follow-up study. Ophthalmology 105:273–281

    Article  PubMed  CAS  Google Scholar 

  8. Winkler von Mohrenfels C, Reischl U, Lohmann CP (2002) Corneal haze after photorefractive keratectomy for myopia: role of collagen IV mRNA typing as a predictor of haze. J Cataract Refract Surg 28:1446–1451

    Article  PubMed  Google Scholar 

  9. Mohan RR et al (2003) Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res 76:71–87

    Article  PubMed  CAS  Google Scholar 

  10. Rajan MS et al (2006) Effects of ablation diameter on long-term refractive stability and corneal transparency after photorefractive keratectomy. Ophthalmology 113:1798–1806

    Article  PubMed  Google Scholar 

  11. Netto MV et al (2006) Stromal haze, myofibroblasts, and surface irregularity after PRK. Exp Eye Res 82:788–797

    Article  PubMed  CAS  Google Scholar 

  12. Chen C et al (2000) Measurement of mRNAs for TGFss and extracellular matrix proteins in corneas of rats after PRK. Invest Ophthalmol Vis Sci 41:4108–4116

    PubMed  CAS  Google Scholar 

  13. Jester JV et al (1999) The cellular basis of corneal transparency: evidence for “corneal crystallins”. J Cell Sci 112:613–622

    PubMed  CAS  Google Scholar 

  14. Moller-Pedersen T et al (1998) Confocal microscopic characterization of wound repair after photorefractive keratectomy. Invest Ophthalmol Vis Sci 39:487–501

    PubMed  CAS  Google Scholar 

  15. Moller-Pedersen T et al (1998) Neutralizing antibody to TGF-beta modulates stromal fibrosis but not regression of photoablative effect following PRK. Curr Eye Res 17:736–747

    Article  PubMed  CAS  Google Scholar 

  16. Braunstein RE et al (1996) Objective measurement of corneal light scattering after excimer laser keratectomy. Ophthalmology 103:439–443

    PubMed  CAS  Google Scholar 

  17. O’Brart DP et al (1995) The effects of ablation diameter on the outcome of excimer laser photorefractive keratectomy. A prospective, randomized, double-blind study. Arch Ophthalmol 113:438–443

    PubMed  CAS  Google Scholar 

  18. Corbett MC et al (1996) Effect of ablation profile on wound healing and visual performance 1 year after excimer laser photorefractive keratectomy. Br J Ophthalmol 80:224–234

    Article  PubMed  CAS  Google Scholar 

  19. Moller-Pedersen T et al (1998) Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea 17:627–639

    Article  PubMed  CAS  Google Scholar 

  20. Long Q et al (2006) Correlation between TGF-beta1 in tears and corneal haze following LASEK and epi-LASIK. J Refract Surg 22:708–712

    PubMed  Google Scholar 

  21. O’Brart DP et al (1994) Excimer laser photorefractive keratectomy for myopia: comparison of 4.00-and 5.00-millimeter ablation zones. J Refract Corneal Surg 10:87–94

    PubMed  CAS  Google Scholar 

  22. Lipshitz I et al (1997) Late onset corneal haze after photorefractive keratectomy for moderate and high myopia. Ophthalmology 104:369–373; discussion 373–374

    PubMed  CAS  Google Scholar 

  23. Hersh PS et al (1997) Results of phase III excimer laser photorefractive keratectomy for myopia. The Summit PRK Study Group. Ophthalmology 104:1535–1553

    PubMed  CAS  Google Scholar 

  24. Shah S, Chatterjee A, Smith RJ (1998) Predictability of spherical photorefractive keratectomy for myopia. Ophthalmology 105:2178–2184; discussion 2184–2185

    Article  PubMed  CAS  Google Scholar 

  25. Siganos DS, Katsanevaki VJ, Pallikaris IG (1999) Correlation of subepithelial haze and refractive regression 1 month after photorefractive keratectomy for myopia. J Refract Surg 15:338–342

    PubMed  CAS  Google Scholar 

  26. Kuo IC, Lee SM, Hwang DG (2004) Late-onset corneal haze and myopic regression after photorefractive keratectomy (PRK). Cornea 23:350–355

    Article  PubMed  Google Scholar 

  27. Taylor SM et al (1994) Effect of depth-upon the smoothness of excimer laser corneal ablation. Optom Vis Sci 71:104–108

    Article  PubMed  CAS  Google Scholar 

  28. Vinciguerra P et al (1998) A method for examining surface and interface irregularities after photorefractive keratectomy and laser in situ keratomileusis: predictor of optical and functional outcomes. J Refract Surg 14(2 Suppl):S204–S206

    PubMed  CAS  Google Scholar 

  29. Vinciguerra P et al (1998) Effect of decreasing surface and interface irregularities after photorefractive keratectomy and laser in situ keratomileusis on optical and functional outcomes. J Refract Surg 14(2 Suppl):S199–S203

    PubMed  CAS  Google Scholar 

  30. Pallikaris IG et al (1999) Photorefractive keratectomy with a small spot laser and tracker. J Refract Surg 15:137–144

    PubMed  CAS  Google Scholar 

  31. Olsen T (1982) Light scattering from the human cornea. Invest Ophthalmol Vis Sci 23:81–86

    PubMed  CAS  Google Scholar 

  32. Soya K, Amano S, Oshika T (2002) Quantification of simulated corneal haze by measuring back-scattered light. Ophthalmic Res 34:380–388

    Article  PubMed  CAS  Google Scholar 

  33. Sasaki K et al (1990) The multi-purpose camera: a new anterior eye segment analysis system. Ophthalmic Res 22(Suppl 1):3–8

    Article  PubMed  Google Scholar 

  34. Jalbert I et al (2003) In vivo confocal microscopy of the human cornea. Br J Ophthalmol 87:225–326

    Article  PubMed  CAS  Google Scholar 

  35. Nagel S, Wiegand W, Thaer AA (1995) [Corneal changes and corneal healing after keratomileusis in situ. In vivo studies using confocal slit-scanning microscopy]. Ophthalmologe 92:397–401

    PubMed  CAS  Google Scholar 

  36. Nagel S et al (1996) [Light scattering study of the cornea in contact lens patients. In vivo studies using confocal slit scanning microscopy]. Ophthalmologe 93:252–256

    PubMed  CAS  Google Scholar 

  37. Slowik C et al (1996) Assessment of corneal alterations following laser in situ keratomileusis by confocal slit scanning microscopy. Ger J Ophthalmol 5:526–531

    PubMed  CAS  Google Scholar 

  38. Moller-Pedersen T et al (1997) Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy. Ophthalmology 104:360–368

    PubMed  CAS  Google Scholar 

  39. Ciancaglini M et al (2001) Morphological evaluation of Schnyder’s central crystalline dystrophy by confocal microscopy before and after phototherapeutic keratectomy. J Cataract Refract Surg 27:1892–1895

    Article  PubMed  CAS  Google Scholar 

  40. Lee JS, Oum BS, Lee SH (2001) Mitomycin C influence on inhibition of cellular proliferation and subsequent synthesis of type I collagen and laminin in primary and recurrent pterygia. Ophthalmic Res 33:140–146

    Article  PubMed  CAS  Google Scholar 

  41. Watanabe J et al (1997) Effects of mitomycin C on the expression of proliferating cell nuclear antigen after filtering surgery in rabbits. Graefes Arch Clin Exp Ophthalmol 235:234–240

    Article  PubMed  CAS  Google Scholar 

  42. Pinilla I et al (1998) Subconjunctival injection of low doses of mitomycin C: effects on fibroblast proliferation. Ophthalmologica 212:306–309

    Article  PubMed  CAS  Google Scholar 

  43. Carones F et al (2002) Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy. J Cataract Refract Surg 28:2088–2095

    Article  PubMed  Google Scholar 

  44. Talamo JH et al (1991) Modulation of corneal wound healing after excimer laser keratomileusis using topical mitomycin C and steroids. Arch Ophthalmol 109:1141–1146

    PubMed  CAS  Google Scholar 

  45. Akarsu C, Onol M, Hasanreisoglu B (2003) Effects of thick Tenon’s capsule on primary trabeculectomy with mitomycin-C. Acta Ophthalmol Scand 81:237–241

    Article  PubMed  Google Scholar 

  46. Oguz H (2003) Mitomycin C and pterygium excision. Ophthalmology 110:2257–2258; author reply 2258

    Article  PubMed  Google Scholar 

  47. Gambato C et al (2005) Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes. Ophthalmology 112:208–218; discussion 219

    Article  PubMed  Google Scholar 

  48. Netto MV, Chalita MR, Krueger RR (2007) Corneal haze following PRK with mitomycin C as a retreatment versus prophylactic use in the contralateral eye. J Refract Surg 23:96–98

    PubMed  Google Scholar 

  49. Azar DT, Jain S (2001) Topical MMC for subepithelial fibrosis after refractive corneal surgery. Ophthalmology 108:239–40

    Article  PubMed  CAS  Google Scholar 

  50. Bedei A et al (2006) Photorefractive keratectomy in high myopic defects with or without intraoperative mitomycin C: 1-year results. Eur J Ophthalmol 16:229–234

    PubMed  CAS  Google Scholar 

  51. Stojanovic A, Ringvold A, and Nitter T (2003) Ascorbate prophylaxis for corneal haze after photorefractive keratectomy. J Refract Surg 19:338–343

    PubMed  Google Scholar 

  52. O’Brart D.P et al (1994) The effects of topical corticosteroids and plasmin inhibitors on refractive outcome, haze, and visual performance after photorefractive keratectomy. A prospective, randomized, observer-masked study. Ophthalmology 101:1565–1574

    PubMed  CAS  Google Scholar 

  53. Rajan MS et al (2204) Effect of exogenous keratinocyte growth factor on corneal epithelial migration after photorefractive keratectomy. J Cataract Refract Surg 30:2200–2206

    Article  Google Scholar 

  54. Majmudar PA et al (2000) Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery. Ophthalmology 107:89–94

    Article  PubMed  CAS  Google Scholar 

  55. Raviv T et al (2000) Mytomycin-C for post-PRK corneal haze. J Cataract Refract Surg 26:1105–1106

    Article  PubMed  CAS  Google Scholar 

  56. Epstein D et al (1994) Excimer retreatment of regression after photorefractive keratectomy. Am J Ophthalmol 117:456–461

    PubMed  CAS  Google Scholar 

  57. Horgan SE et al (1999) Phototherapeutic smoothing as an adjunct to photorefractive keratectomy in porcine corneas. J Refract Surg 15:331–333

    PubMed  CAS  Google Scholar 

  58. Serrao S, Lombardo M, Mondini F (2003) Photorefractive keratectomy with and without smoothing: a bilateral study. J Refract Surg 19:58–64

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fahd, D., de la Cruz, J., Jain, S., Azar, D. (2008). Corneal Haze after Refractive Surgery. In: Alió, J.L., Azar, D.T. (eds) Management of Complications in Refractive Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37584-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-37584-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-37583-8

  • Online ISBN: 978-3-540-37584-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics