Transient Receptor Potential (TRP) Channels pp 155-171

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)

Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel

  • S. C. Pingle
  • J. A. Matta
  • G. P. Ahern

Abstract

TRPV1, the archetypal member of the vanilloid TRP family, was initially identified as the receptor for capsaicin, the pungent ingredient in hot chili peppers. The receptor has a diverse tissue distribution, with high expression in sensory neurons. TRPV1 is a nonselective cation channel with significant permeability to calcium, protons, and large polyvalent cations. It is the most polymodal TRP channel, being activated by numerous stimuli, including heat, voltage, vanilloids, lipids, and protons/cations. TRPV1 acts as a molecular integrator of physical and chemical stimuli in peripheral nociceptor terminals and plays a critical role in thermal inflammatory hyperalgesia. In addition, TRPV1 may regulate a variety of physiological functions in different organ systems. Various second messenger systems regulate TRPV1 activity, predominantly by serine-threonine phosphorylation. In this review, we provide a concise summary of the information currently available about this channel.

Keywords

TRPV1 Capsaicin Pain 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • S. C. Pingle
    • 1
  • J. A. Matta
    • 1
  • G. P. Ahern
    • 1
  1. 1.Department of PharmacologyGeorgetown University Medical CenterWashington DCUSA

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