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The Theory of APL Revisited

  • P. P. Scaglioni
  • P. P. Pandolfi
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 313)

Abstract

Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in the majority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed.

Keywords

Fusion Protein Acute Promyelocytic Leukemia Retinoic Acid Receptor Transgenic Animal Model Retinoic Acid Receptor Alpha 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • P. P. Scaglioni
    • 1
  • P. P. Pandolfi
    • 1
  1. 1.Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer CenterSloan-Kettering InstituteNew YorkUSA

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