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The PLZF Gene of t(11;17)-Associated APL

  • M. J. McConnell
  • J. D. Licht
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 313)

Abstract

The PLZF gene is one of five partners fused to the retinoic acid receptor αin acute promyelocytic leukemia. PLZF encodes a DNA-binding transcriptional repressor and the PLZF-RARα fusion protein like other RARα fusions can inhibit the genet program mediated by the wild tpe retinoic acid receptor. However an increasing body of literature indicates an important role for the PLZF gene in growth control and development. This information suggests that loss of PLZF function might also contribute to leukemogenesis.

Keywords

Transcriptional Repression Acute Promyelocytic Leukemia Promyelocytic Leukemia Retinoic Acid Receptor Retinoic Acid Receptor Alpha 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • M. J. McConnell
    • 1
  • J. D. Licht
    • 1
  1. 1.Division of Hematology/OncologyNorthwestern University, Feinberg School of MedicineChicagoUSA

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