Kaposi Sarcoma Herpesvirus: New Perspectives pp 263-287

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 312)

Kaposi Sarcoma-Associated Herpesvirus and Other Viruses in Human Lymphomagenesis

  • E. Cesarman
  • E. A. Mesri

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is associated with a specific subset of lymphoproliferative disorders. These include two main categories. The first is primary effusion lymphomas and related solid variants. The second is multicentric Castleman disease, from which KSHV-positive plasmablastic lymphomas can arise. KSHV contributes to lymphomagenesis by subverting the host cell molecular signaling machinery to deregulate cell growth and survival. KSHV expresses a selected set of genes in the lymphoma cells, encoding viral proteins that play important roles in KSHV lymphomagenesis. Deregulation of the NF-κB pathway is an important strategy used by KSHV to promote lymphoma cell survival, and the viral protein vFLIP is essential for this process. Two other viruses that are well documented to be causally associated with lymphoid neoplasia in humans are Epstein-Barr virus (EBV/HHV-4) and human T-cell lymphotropic virus (HTLV-1). Both of these are similar to KSHV in their use of viral proteins to promote cell survival by deregulating the NF-κB pathway. Here we review the basic information and recent developments that have contributed to our knowledge of lymphomas caused by KSHV and other viruses. The understanding of the mechanisms of viral lymphomagenesis should lead to the identification of novel therapeutic targets and to the development of rationally designed therapies.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • E. Cesarman
    • 1
  • E. A. Mesri
    • 2
  1. 1.Department of Pathology and Laboratory MedicineWeill Medical College of Cornell UniversityNew YorkUSA
  2. 2.Viral Oncology Program and Department of Microbiology and ImmunologySylvester Comprehensive Cancer Center and University of Miami Miller School of MedicineMiamiUSA

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