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Pathophysiology of Hirschsprung’s Disease

  • P. Puri
  • S. Montedonico

Abstract

The basic pathophysiological feature in Hirschsprung’s disease (HD) is a functional obstruction caused by a narrowed distal aganglionic colonic segment that prevents the propagation of peristaltic waves. Despite extensive research, the pathophysiology of HD is not fully understood. There is no clear explanation for the occurrence of spastic or tonically contracted aganglionic segment of bowel.

Keywords

Vasoactive Intestinal Peptide Enteric Nervous System Neural Cell Adhesion Molecule Enteroendocrine Cell NADPH Diaphorase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • P. Puri
    • 1
  • S. Montedonico
    • 1
  1. 1.Children’s Research Centre, Our Lady’s Children’s HospitalUniversity College of DublinCrumlinIreland

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