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Intestinal Neuronal Malformations (IND): Clinical Experience and Treatment

  • A.M. Holschneider
  • P. Puri
  • L.H. Homrighausen
  • W. Meier-Ruge

Abstract

Neuronal intestinal dysplasia (IND or NID) was first described by Meier-Ruge in 1971 as a condition of unknown pathogenesis which is usually associated with obstruction of the lower intestine [1]. It may be induced, like Hirschsprung’s disease (HD), by an underlying autoimmune mechanism [2], a deficient production of trophic factors such as laminin A [3] or a genetic defect. The main problem is that it remains controversial as to whether or not there is a causal relationship between specific histological findings and clinical symptoms, in particular since so-called pathological innervation patterns have been described in the proximal colon of patients with fetal obstruction [4, 5] and in normal controls.

Keywords

Ganglion Cell AChE Activity Myenteric Plexus Rectal Biopsy Intestinal Neuronal Dysplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • A.M. Holschneider
    • 1
    • 2
  • P. Puri
    • 3
  • L.H. Homrighausen
    • 2
  • W. Meier-Ruge
    • 4
  1. 1.Bergisch GladbachGermany
  2. 2.The Children’s Hospital of CologneCologneGermany
  3. 3.Children’s Research Centre, Our Lady’s Children’s HospitalUniversity College of DublinCrumlinIreland
  4. 4.Department of PathologyUniversity of BaselBaselSwitzerland

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