Intestinal Neuronal Malformations (IND): Clinical Experience and Treatment

  • A.M. Holschneider
  • P. Puri
  • L.H. Homrighausen
  • W. Meier-Ruge


Neuronal intestinal dysplasia (IND or NID) was first described by Meier-Ruge in 1971 as a condition of unknown pathogenesis which is usually associated with obstruction of the lower intestine [1]. It may be induced, like Hirschsprung’s disease (HD), by an underlying autoimmune mechanism [2], a deficient production of trophic factors such as laminin A [3] or a genetic defect. The main problem is that it remains controversial as to whether or not there is a causal relationship between specific histological findings and clinical symptoms, in particular since so-called pathological innervation patterns have been described in the proximal colon of patients with fetal obstruction [4, 5] and in normal controls.


Ganglion Cell AChE Activity Myenteric Plexus Rectal Biopsy Intestinal Neuronal Dysplasia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • A.M. Holschneider
    • 1
    • 2
  • P. Puri
    • 3
  • L.H. Homrighausen
    • 2
  • W. Meier-Ruge
    • 4
  1. 1.Bergisch GladbachGermany
  2. 2.The Children’s Hospital of CologneCologneGermany
  3. 3.Children’s Research Centre, Our Lady’s Children’s HospitalUniversity College of DublinCrumlinIreland
  4. 4.Department of PathologyUniversity of BaselBaselSwitzerland

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