Analgesia pp 65-93 | Cite as

Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 177)

Abstract

Antipyretic analgesics are a group of heterogeneous substances including acidic (nonsteroidal antiinflammatory drugs, NSAIDs) and nonacidic (paracetamol, pyrazolinones) drugs. Moreover, various selective cyclooxygenase-2 (COX-2) inhibitors with improved gastrointestinal tolerability as compared with conventional NSAIDs have been established for symptomatic pain treatment in recent years. The present review summarizes the pharmacology of all of these drugs with particular emphasis on their rational use based on the diverse pharmacokinetic characteristics and adverse drug reaction profiles. Referring to the current debate, potential mechanisms underlying cardiovascular side effects associated with long-term use of COX inhibitors are discussed.

Keywords

Nonsteroidal antiinflammatory drugs Selective cyclooxygenase-2 inhibitors Paracetamol Pyrazolinones Pharmacokinetics Mechanisms of hyperalgesia 

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Department of Experimental and Clinical Pharmacology and ToxicologyFriedrich Alexander University Erlangen-NurembergErlangenGermany

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