Herpes Simplex Virus and the Chemokines That Mediate the Inflammation

  • D. J. J. Carr
  • L. Tomanek
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 303)


Herpes simplex viruses (HSV) are highly pervasive pathogens in the human host with a seroconversion rate upwards of 60% worldwide. HSV type 1 (HSV-1) is associated with the disease herpetic stromal keratitis, the leading cause of infectious corneal blindness in the industrializedworld. Individuals suffering fromgenital herpes associated withHSV type 2 (HSV-2) are found to be two- to threefoldmore susceptible in acquiring human immunodeficiency virus (HIV). The morbidity associated with these infections is principally due to the inflammatory response, the development of lesions, and scarring. Chemokines have become an important aspect in understanding the host immune response to microbial pathogens due in part to the timing of expression. In this paper, we will explore the current understanding of chemokine production as it relates to the orchestration of the immune response to HSV infection.


Trigeminal Ganglion Genital Herpes CXCL10 Expression Herpes Simplex Virus Corneal Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • D. J. J. Carr
    • 1
    • 2
  • L. Tomanek
    • 1
  1. 1.Department of OphthalmologyUniversity of OklahomaOklahoma CityUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Oklahoma, Health Sciences CenterOklahoma CityUSA

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