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Functional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System

  • T. E. Lane
  • J. L. Hardison
  • K. B. Walsh
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 303)

Abstract

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS.

Keywords

Experimental Autoimmune Encephalomyelitis Chemokine Receptor Severe Acute Respiratory Syndrome Mouse Hepatitis Virus Severe Acute Respiratory Syndrome Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • T. E. Lane
    • 1
  • J. L. Hardison
    • 1
  • K. B. Walsh
    • 1
  1. 1.Department of Molecular Biology and BiochemistryUniversity of CaliforniaIrvineUSA

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